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Parkinson Disease: HELP
Articles by J. E. Rofina
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, J. E. Rofina wrote the following article about Parkinson Disease.
+ Citations + Abstracts
1 Review Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases. 2016

Youssef, S A / Capucchio, M T / Rofina, J E / Chambers, J K / Uchida, K / Nakayama, H / Head, E. ·Department of Pathobiology, Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands sameh_youssef@sbcglobal.net. · Department of Veterinary Sciences, Torino University, Torino, Italy. · Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands. · Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan. · Sanders Brown Center on Aging, Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, UK, USA. ·Vet Pathol · Pubmed #26869150.

ABSTRACT: According to the WHO, the proportion of people over 60 years is increasing and expected to reach 22% of total world's population in 2050. In parallel, recent animal demographic studies have shown that the life expectancy of pet dogs and cats is increasing. Brain aging is associated not only with molecular and morphological changes but also leads to different degrees of behavioral and cognitive dysfunction. Common age-related brain lesions in humans include brain atrophy, neuronal loss, amyloid plaques, cerebrovascular amyloid angiopathy, vascular mineralization, neurofibrillary tangles, meningeal osseous metaplasia, and accumulation of lipofuscin. In aging humans, the most common neurodegenerative disorder is Alzheimer's disease (AD), which progressively impairs cognition, behavior, and quality of life. Pathologic changes comparable to the lesions of AD are described in several other animal species, although their clinical significance and effect on cognitive function are poorly documented. This review describes the commonly reported age-associated neurologic lesions in domestic and laboratory animals and the relationship of these lesions to cognitive dysfunction. Also described are the comparative interspecies similarities and differences to AD and other human neurodegenerative diseases including Parkinson's disease and progressive supranuclear palsy, and the spontaneous and transgenic animal models of these diseases.