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Parkinson Disease: HELP
Articles by Paul M. Thompson
Based on 6 articles published since 2010
(Why 6 articles?)
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Between 2010 and 2020, Paul M. Thompson wrote the following 6 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Article Novel genetic loci underlying human intracranial volume identified through genome-wide association. 2016

Adams, Hieab H H / Hibar, Derrek P / Chouraki, Vincent / Stein, Jason L / Nyquist, Paul A / Rentería, Miguel E / Trompet, Stella / Arias-Vasquez, Alejandro / Seshadri, Sudha / Desrivières, Sylvane / Beecham, Ashley H / Jahanshad, Neda / Wittfeld, Katharina / Van der Lee, Sven J / Abramovic, Lucija / Alhusaini, Saud / Amin, Najaf / Andersson, Micael / Arfanakis, Konstantinos / Aribisala, Benjamin S / Armstrong, Nicola J / Athanasiu, Lavinia / Axelsson, Tomas / Beiser, Alexa / Bernard, Manon / Bis, Joshua C / Blanken, Laura M E / Blanton, Susan H / Bohlken, Marc M / Boks, Marco P / Bralten, Janita / Brickman, Adam M / Carmichael, Owen / Chakravarty, M Mallar / Chauhan, Ganesh / Chen, Qiang / Ching, Christopher R K / Cuellar-Partida, Gabriel / Braber, Anouk Den / Doan, Nhat Trung / Ehrlich, Stefan / Filippi, Irina / Ge, Tian / Giddaluru, Sudheer / Goldman, Aaron L / Gottesman, Rebecca F / Greven, Corina U / Grimm, Oliver / Griswold, Michael E / Guadalupe, Tulio / Hass, Johanna / Haukvik, Unn K / Hilal, Saima / Hofer, Edith / Hoehn, David / Holmes, Avram J / Hoogman, Martine / Janowitz, Deborah / Jia, Tianye / Kasperaviciute, Dalia / Kim, Sungeun / Klein, Marieke / Kraemer, Bernd / Lee, Phil H / Liao, Jiemin / Liewald, David C M / Lopez, Lorna M / Luciano, Michelle / Macare, Christine / Marquand, Andre / Matarin, Mar / Mather, Karen A / Mattheisen, Manuel / Mazoyer, Bernard / McKay, David R / McWhirter, Rebekah / Milaneschi, Yuri / Mirza-Schreiber, Nazanin / Muetzel, Ryan L / Maniega, Susana Muñoz / Nho, Kwangsik / Nugent, Allison C / Loohuis, Loes M Olde / Oosterlaan, Jaap / Papmeyer, Martina / Pappa, Irene / Pirpamer, Lukas / Pudas, Sara / Pütz, Benno / Rajan, Kumar B / Ramasamy, Adaikalavan / Richards, Jennifer S / Risacher, Shannon L / Roiz-Santiañez, Roberto / Rommelse, Nanda / Rose, Emma J / Royle, Natalie A / Rundek, Tatjana / Sämann, Philipp G / Satizabal, Claudia L / Schmaal, Lianne / Schork, Andrew J / Shen, Li / Shin, Jean / Shumskaya, Elena / Smith, Albert V / Sprooten, Emma / Strike, Lachlan T / Teumer, Alexander / Thomson, Russell / Tordesillas-Gutierrez, Diana / Toro, Roberto / Trabzuni, Daniah / Vaidya, Dhananjay / Van der Grond, Jeroen / Van der Meer, Dennis / Van Donkelaar, Marjolein M J / Van Eijk, Kristel R / Van Erp, Theo G M / Van Rooij, Daan / Walton, Esther / Westlye, Lars T / Whelan, Christopher D / Windham, Beverly G / Winkler, Anderson M / Woldehawariat, Girma / Wolf, Christiane / Wolfers, Thomas / Xu, Bing / Yanek, Lisa R / Yang, Jingyun / Zijdenbos, Alex / Zwiers, Marcel P / Agartz, Ingrid / Aggarwal, Neelum T / Almasy, Laura / Ames, David / Amouyel, Philippe / Andreassen, Ole A / Arepalli, Sampath / Assareh, Amelia A / Barral, Sandra / Bastin, Mark E / Becker, Diane M / Becker, James T / Bennett, David A / Blangero, John / van Bokhoven, Hans / Boomsma, Dorret I / Brodaty, Henry / Brouwer, Rachel M / Brunner, Han G / Buckner, Randy L / Buitelaar, Jan K / Bulayeva, Kazima B / Cahn, Wiepke / Calhoun, Vince D / Cannon, Dara M / Cavalleri, Gianpiero L / Chen, Christopher / Cheng, Ching-Yu / Cichon, Sven / Cookson, Mark R / Corvin, Aiden / Crespo-Facorro, Benedicto / Curran, Joanne E / Czisch, Michael / Dale, Anders M / Davies, Gareth E / De Geus, Eco J C / De Jager, Philip L / de Zubicaray, Greig I / Delanty, Norman / Depondt, Chantal / DeStefano, Anita L / Dillman, Allissa / Djurovic, Srdjan / Donohoe, Gary / Drevets, Wayne C / Duggirala, Ravi / Dyer, Thomas D / Erk, Susanne / Espeseth, Thomas / Evans, Denis A / Fedko, Iryna O / Fernández, Guillén / Ferrucci, Luigi / Fisher, Simon E / Fleischman, Debra A / Ford, Ian / Foroud, Tatiana M / Fox, Peter T / Francks, Clyde / Fukunaga, Masaki / Gibbs, J Raphael / Glahn, David C / Gollub, Randy L / Göring, Harald H H / Grabe, Hans J / Green, Robert C / Gruber, Oliver / Gudnason, Vilmundur / Guelfi, Sebastian / Hansell, Narelle K / Hardy, John / Hartman, Catharina A / Hashimoto, Ryota / Hegenscheid, Katrin / Heinz, Andreas / Le Hellard, Stephanie / Hernandez, Dena G / Heslenfeld, Dirk J / Ho, Beng-Choon / Hoekstra, Pieter J / Hoffmann, Wolfgang / Hofman, Albert / Holsboer, Florian / Homuth, Georg / Hosten, Norbert / Hottenga, Jouke-Jan / Hulshoff Pol, Hilleke E / Ikeda, Masashi / Ikram, M Kamran / Jack, Clifford R / Jenkinson, Mark / Johnson, Robert / Jönsson, Erik G / Jukema, J Wouter / Kahn, René S / Kanai, Ryota / Kloszewska, Iwona / Knopman, David S / Kochunov, Peter / Kwok, John B / Lawrie, Stephen M / Lemaître, Hervé / Liu, Xinmin / Longo, Dan L / Longstreth, W T / Lopez, Oscar L / Lovestone, Simon / Martinez, Oliver / Martinot, Jean-Luc / Mattay, Venkata S / McDonald, Colm / McIntosh, Andrew M / McMahon, Katie L / McMahon, Francis J / Mecocci, Patrizia / Melle, Ingrid / Meyer-Lindenberg, Andreas / Mohnke, Sebastian / Montgomery, Grant W / Morris, Derek W / Mosley, Thomas H / Mühleisen, Thomas W / Müller-Myhsok, Bertram / Nalls, Michael A / Nauck, Matthias / Nichols, Thomas E / Niessen, Wiro J / Nöthen, Markus M / Nyberg, Lars / Ohi, Kazutaka / Olvera, Rene L / Ophoff, Roel A / Pandolfo, Massimo / Paus, Tomas / Pausova, Zdenka / Penninx, Brenda W J H / Pike, G Bruce / Potkin, Steven G / Psaty, Bruce M / Reppermund, Simone / Rietschel, Marcella / Roffman, Joshua L / Romanczuk-Seiferth, Nina / Rotter, Jerome I / Ryten, Mina / Sacco, Ralph L / Sachdev, Perminder S / Saykin, Andrew J / Schmidt, Reinhold / Schofield, Peter R / Sigurdsson, Sigurdur / Simmons, Andy / Singleton, Andrew / Sisodiya, Sanjay M / Smith, Colin / Smoller, Jordan W / Soininen, Hilkka / Srikanth, Velandai / Steen, Vidar M / Stott, David J / Sussmann, Jessika E / Thalamuthu, Anbupalam / Tiemeier, Henning / Toga, Arthur W / Traynor, Bryan J / Troncoso, Juan / Turner, Jessica A / Tzourio, Christophe / Uitterlinden, Andre G / Hernández, Maria C Valdés / Van der Brug, Marcel / Van der Lugt, Aad / Van der Wee, Nic J A / Van Duijn, Cornelia M / Van Haren, Neeltje E M / Van T Ent, Dennis / Van Tol, Marie-Jose / Vardarajan, Badri N / Veltman, Dick J / Vernooij, Meike W / Völzke, Henry / Walter, Henrik / Wardlaw, Joanna M / Wassink, Thomas H / Weale, Michael E / Weinberger, Daniel R / Weiner, Michael W / Wen, Wei / Westman, Eric / White, Tonya / Wong, Tien Y / Wright, Clinton B / Zielke, H Ronald / Zonderman, Alan B / Deary, Ian J / DeCarli, Charles / Schmidt, Helena / Martin, Nicholas G / De Craen, Anton J M / Wright, Margaret J / Launer, Lenore J / Schumann, Gunter / Fornage, Myriam / Franke, Barbara / Debette, Stéphanie / Medland, Sarah E / Ikram, M Arfan / Thompson, Paul M / and others. ·Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. · Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands. · Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA. · Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA. · Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, France. · Framingham Heart Study, Framingham, Massachusetts, USA. · Department of Genetics and UNC Neuroscience Center, University of North Carolina (UNC), Chapel Hill, North Carolina, USA. · Department of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA. · QIMR Berghofer Medical Research Institute, Brisbane, Australia. · Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. · Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. · Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands. · Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands. · Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands. · MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. · Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA. · John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. · German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald, Germany. · Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany. · Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands. · Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. · The Royal College of Surgeons in Ireland, Dublin 2, Ireland. · Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden. · Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA. · Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA. · Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Illinois, USA. · Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK. · Department of Computer Science, Lagos State University, Lagos, Nigeria. · Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK. · Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia. · Mathematics and Statistics, Murdoch University, Perth, Australia. · NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. · NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. · Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. · Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. · Hospital for Sick Children, University of Toronto, Toronto, Canada. · Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. · Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands. · Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands. · Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA. · G.H. Sergievsky Center, Columbia University Medical Center, New York, New York, USA. · Department of Neurology, Columbia University Medical Center, New York, New York, USA. · Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. · Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada. · Department of Psychiatry and Biomedical Engineering, McGill University, Montreal, Canada. · INSERM Unit U1219, University of Bordeaux, France. · Lieber Institute for Brain Development, Baltimore, Maryland, USA. · Interdepartmental Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, California, USA. · Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands. · Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany. · Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA. · Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, North Carolina, USA. · NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France. · Maison de Solenn, Adolescent Psychopathology and Medicine Department, APHP Hospital Cochin, Paris, France. · Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. · Harvard Medical School, Boston, Massachusetts, USA. · Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts, USA. · NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway. · Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. · Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. · Karakter Child and Adolescent Psychiatry University Center, Nijmegen, the Netherlands. · King's College London, Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychology, Psychiatry and Neurosciene, London, UK. · Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany. · Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA. · Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands. · International Max Planck Research School for Language Sciences, Nijmegen, the Netherlands. · Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany. · Department of Research and Development, Diakonhjemmet Hospital, Oslo, Norway. · Department of Pharmacology, National University of Singapore, Singapore. · Memory Aging and Cognition Centre (MACC), National University Health System, Singapore. · Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria. · Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, Austria, Graz, Austria. · Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany. · Department of Psychology, Yale University, New Haven, Connecticut, USA. · UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK. · Department of Medicine, Imperial College London, London, UK. · Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA. · Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA. · Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA. · Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany. · Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Lexington, Massachusetts, USA. · Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. · Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK. · Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands. · Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. · Department of Biomedicine, Aarhus University, Aarhus, Denmark. · The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen, Denmark. · Center for integrated Sequencing, iSEQ, Aarhus University, Aarhus, Denmark. · UMR5296 University of Bordeaux, CNRS, CEA, Bordeaux, France. · Department of Psychiatry, Yale University, New Haven, Connecticut, USA. · Olin Neuropsychiatric Research Center, Hartford, Connecticut, USA. · Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. · Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands. · Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA. · Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA. · Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, the Netherlands. · Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK. · Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Switzerland. · School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, Rotterdam, the Netherlands. · Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA. · Department of Medical and Molecular Genetics, King's College London, London, UK. · The Jenner Institute Laboratories, University of Oxford, Oxford, UK. · Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain. · CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, Spain. · Psychosis Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin. · Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. · Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA. · Department of Epidemiology and Public Health Sciences, University of Miami, Miller School of Medicine, Miami, Florida, USA. · Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia. · Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia. · Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands. · Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, USA. · Department of Cognitive Sciences, University of California, San Diego, USA. · Icelandic Heart Association, Kopavogur, Iceland. · Faculty of Medicine, University of Iceland, Reykjavik, Iceland. · Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA. · Queensland Brain Institute, University of Queensland, Brisbane, Australia. · Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. · School of Computing Engineering and Mathematics, Western Sydney University, Parramatta, Australia. · Neuroimaging Unit,Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL, Santander, Cantabria, Spain. · Institut Pasteur, Paris, France. · Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. · GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. · Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. · Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. · Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, Utrecht, the Netherlands. · Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California, USA. · NORMENT - KG Jebsen Centre, Department of Psychology, University of Oslo, Oslo, Norway. · Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA. · FMRIB Centre, University of Oxford, Oxford, UK. · University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany. · Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA. · Biospective Inc, Montreal, Quebec, Canada, Montréal, Québec, Canada. · Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden. · South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA. · Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. · Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. · National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia. · Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia. · Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. · Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Dementia Collaborative Research Centre - Assessment and Better Care, UNSW, Sydney, Australia. · Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands. · Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA. · Department of Evolution and Genetics, Dagestan State University, Makhachkala, Dagestan, Russia. · The Mind Research Network and LBERI, Albuquerque, New Mexico, USA. · Department of ECE, University of New Mexico, Albuquerque, New Mexico, USA. · Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. · Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore. · Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. · Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland. · Institute of Human Genetics, University of Bonn, Bonn, Germany. · Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany. · Center for Multimodal Imaging and Genetics, University of California, San Diego, California, USA. · Department of Neurosciences, University of California, San Diego, California, USA. · Department of Radiology, University of California, San Diego, California, USA. · Department of Psychiatry, University of California, San Diego, California, USA. · Department of Cognitive Science, University of California, San Diego, California, USA. · Avera Institute for Human Genetics, Sioux Falls, South Dakota, USA. · Program in Translational NeuroPsychiatric Genomics, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA. · Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. · Broad Institute, Cambridge, Massachusetts, USA. · Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia. · Neurology Division, Beaumont Hospital, Dublin, 9, Ireland. · Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. · Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. · Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition and Genomics Centre (NICOG) and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland. · Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland. · Janssen Research and Development, LLC, Titusville, New Jersey, USA. · Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany. · Intramural Research Program of the National Institute on Aging, Baltimore, Maryland, USA. · Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA. · Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK. · Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA. · University of Texas Health Science Center, San Antonio, Texas, USA. · Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan. · Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. · Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan. · Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan. · Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany. · German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. · Department of Psychology, VU University Amsterdam, Amsterdam, the Netherlands. · Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA. · HMNC Brain Health, Munich, Germany. · Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. · Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan. · Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. · NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, Maryland, USA. · School of Psychology, University of Sussex, Brighton, UK. · Institute of Cognitive Neuroscience, University College London, London, UK. · Department of Neuroinformatics, Araya Brain Imaging, Tokyo, Japan. · Medical University of Lodz, Lodz, Poland. · Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. · Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA. · Neuroscience Research Australia, Sydney, Australia. · School of Medical Sciences, UNSW, Sydney, Australia. · Columbia University Medical Center, New York, New York, USA. · Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. · Department of Neurology, University of Washington, Seattle, Washington, USA. · Department of Epidemiology, University of Washington, Seattle, Washington, USA. · Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Department of Psychiatry, University of Oxford, Oxford, UK. · NIHR Dementia Biomedical Research Unit, King's College London, London, UK. · Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, California, USA. (and more) ·Nat Neurosci · Pubmed #27694991.

ABSTRACT: Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρ

2 Article Mapping cortical atrophy in Parkinson's disease patients with dementia. 2013

Hwang, Kristy S / Beyer, Mona K / Green, Amity E / Chung, Christine / Thompson, Paul M / Janvin, Carmen / Larsen, Jan P / Aarsland, Dag / Apostolova, Liana G. ·Department of Neurology, University of California, Los Angeles, CA, USA. ·J Parkinsons Dis · Pubmed #23938313.

ABSTRACT: BACKGROUND: Cognitive impairment is very common in patients with Parkinson's disease (PD). Brain changes accompanying cognitive decline in PD are still not fully established. METHODS: We applied cortical pattern matching and cortical thickness analyses to the three-dimensional T1-weighted brain MRI scans of 14 age-matched cognitively normal elderly (NC), 12 cognitively normal PD (PDC), and 11 PD dementia (PDD) subjects. We used linear regression models to investigate the effect of diagnosis on cortical thickness. All maps were adjusted for multiple comparisons using permutation testing with a threshold p < 0.01. RESULTS: PDD showed significantly thinner bilateral sensorimotor, perisylvian, lateral parietal, as well as right posterior cingulate, parieto-occipital, inferior temporal and lateral frontal cortices relative to NC (left p(corrected) = 0.06, right p(corrected) = 0.009). PDD showed significantly thinner bilateral sensorimotor, right frontal and right parietal-occipital cortices relative to PDC (right p(corrected) = 0.05). The absolute difference in cortical thickness between PDD and the other diagnostic groups ranged from 3% to 19%. CONCLUSION: Our data shows that cognitive decline in PD is associated with cortical atrophy. PDD subjects have the most widespread gray matter atrophy suggesting more cortical involvement as PD patients progress to dementia.

3 Article Cerebrospinal fluid Aβ levels correlate with structural brain changes in Parkinson's disease. 2013

Beyer, Mona K / Alves, Guido / Hwang, Kristy S / Babakchanian, Sona / Bronnick, Kolbjorn S / Chou, Yi-Yu / Dalaker, Turi O / Kurz, Martin W / Larsen, Jan P / Somme, Johanne H / Thompson, Paul M / Tysnes, Ole-Bjørn / Apostolova, Liana G. ·The Norwegian Center for Movement Disorders, Stavanger University Hospital, Stavanger, Norway. mona.beyer@lyse.net ·Mov Disord · Pubmed #23408705.

ABSTRACT: ParkWest is a large Norwegian multicenter study of newly diagnosed drug-naïve subjects with Parkinson's disease (PD). Cognitively normal PD subjects (PDCN) and PD subjects with mild cognitive impairment (PDMCI) from this cohort have significant hippocampal atrophy and ventricular enlargement, compared to normal controls. Here, we aimed to investigate whether the same structural changes are associated with cerebrospinal fluid (CSF) levels of amyloid beta (Aβ)38 , Aβ40 , Aβ42 , total tau (t-tau), and phosphorylated tau (p-tau). We performed three-dimensional radial distance analyses of the hippocampi and lateral ventricles using the MRI data from ParkWest subjects who provided CSF at baseline. Our sample consisted of 73 PDCN and 18 PDMCI subjects. We found significant associations between levels of all three CSF Aβ analytes and t-tau and lateral ventricular enlargement in the pooled sample. In the PDCN sample, all three amyloid analytes showed significant associations with the radial distance of the occipital and frontal horns of the lateral ventricles. CSF Aβ38 and Aβ42 showed negative associations, with enlargement in occipital and frontal horns of the lateral ventricles in the pooled sample, and a negative association with the occipital horns in PDMCI. CSF Aβ levels in early PD correlate with ventricular enlargement, previously associated with PD dementia. Therefore, CSF and MRI markers may help identify PD patients at high risk for developing cognitive decline and dementia in the course of their illness. Contrary to Alzheimer's disease, we found no associations between CSF t-tau and p-tau and hippocampal atrophy.

4 Article Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease. 2013

Beyer, Mona K / Bronnick, Kolbjorn S / Hwang, Kristy S / Bergsland, Niels / Tysnes, Ole Bjorn / Larsen, Jan Petter / Thompson, Paul M / Somme, Johanne H / Apostolova, Liana G. ·Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway. monbey@ous-hf.no ·J Neurol Neurosurg Psychiatry · Pubmed #23154124.

ABSTRACT: BACKGROUND AND OBJECTIVE: Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance. METHODS: We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre. RESULTS: There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043). CONCLUSIONS: At the time of PD diagnosis, subjects' verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.

5 Article Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment. 2012

Apostolova, Liana / Alves, Guido / Hwang, Kristy S / Babakchanian, Sona / Bronnick, Kolbjorn S / Larsen, Jan Petter / Thompson, Paul M / Chou, Yi-Yu / Tysnes, Ole B / Vefring, Hege K / Beyer, Mona K. ·Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. lapostolova@mednet.ucla.edu ·Neurobiol Aging · Pubmed #21813212.

ABSTRACT: We analyzed T1-weighted brain magnetic resonance imaging data of 100 cognitively normal elderly controls (NC), 127 cognitively normal Parkinson's disease (PD; PDCN) and 31 PD-associated mild cognitive impairment (PDMCI) subjects from the Norwegian ParkWest study. Using automated segmentation methods, followed by the radial distance technique and multiple linear regression we studied the effect of clinical diagnosis on hippocampal and ventricular radial distance while adjusting for age, education, and scanning site. PDCN subjects had significantly smaller bilateral hippocampal radial distance relative to NC. Nonamnestic PDMCI subjects showed smaller right hippocampal radial distance relative to NC. PDMCI subjects showed significant enlargement of all portions of the lateral ventricles relative to NC and significantly larger bilateral temporal and occipital and left frontal lateral ventricular expansion relative to PDCN subjects. Nonamnestic PDMCI subjects showed significant ventricular enlargement spanning all parts of the lateral ventricle while those with amnestic PDMCI showed changes localized to the left occipital horn. Hippocampal atrophy and lateral ventricular enlargement show promise as structural biomarkers for PD.

6 Article Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia. 2010

Apostolova, Liana G / Beyer, Mona / Green, Amity E / Hwang, Kristy S / Morra, Jonathan H / Chou, Yi-Yu / Avedissian, Christina / Aarsland, Dag / Janvin, Carmen C / Larsen, Jan P / Cummings, Jeffrey L / Thompson, Paul M. ·Department of Neurology, David Geffen School of Medicine, UCLA, California, USA. lapostolova@mednet.ucla.edu ·Mov Disord · Pubmed #20437538.

ABSTRACT: Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between-group differences in radial distance ranged between 20-30% for caudate and 5-20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend-level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement.