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Parkinson Disease: HELP
Articles by Ting-Ting Zhou
Based on 7 articles published since 2010
(Why 7 articles?)
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Between 2010 and 2020, Ting Zhou wrote the following 7 articles about Parkinson Disease.
 
+ Citations + Abstracts
1 Review Multiple pathways for natural product treatment of Parkinson's disease: A mini review. 2019

Li, Jingwen / Long, Xi / Hu, Jichuan / Bi, Juan / Zhou, Ting / Guo, Xingfang / Han, Chao / Huang, Jinsha / Wang, Tao / Xiong, Nian / Lin, Zhicheng. ·Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. · Department of Neurology, People's Hospital of Dongxihu District, Wuhan, Hubei 430040, China. · Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Neurology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China. · Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Neurology, People's Hospital of Dongxihu District, Wuhan, Hubei 430040, China. Electronic address: nianxiong@hust.edu.cn. · Laboratory of Psychiatric Neurogenomics, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States. Electronic address: zlin@mclean.harvard.edu. ·Phytomedicine · Pubmed #31130327.

ABSTRACT: BACKGROUND: It is established that natural medicines for Parkinson's disease (PD) provide an antioxidant activity in preventing dopaminergic neurons from degeneration. However, the underlying and related molecular details remain poorly understood. METHODS AND AIM: We review published in vitro and rodent studies of natural products in PD models with the aim to identify common molecular pathways contributing to the treatment efficacy. Commonly regulated genes were identified through the systemic literature search and further analyzed from a network perspective. FINDINGS: Approximately thirty different types of natural products have been investigated for their ability to regulate protein density and gene activity in various experimental systems. Most were found to attenuate neurotoxin-induced regulations. Three common PD pathways are involved. The most studied pathway was neuronal development/anti-apoptosis consisting of Bax/Bcl-2, caspases 3/9, and MAPK signaling. Another well studied was anti-inflammation comprising iNOS, nNOS, Nrf2/ARE, cytokines, TNFα, COX2 and MAPK signaling. The third pathway referred to dopamine transmission modulation with upregulated VMAT2, DAT, NURR1 and GDNF levels. To date, HIPK2, a conserved serine/threonine kinase and transcriptional target of Nrf2 in an anti-apoptosis signaling pathway, is the first protein identified as the direct binding target of a natural product (ZMHC). IMPLICATIONS: Natural products may utilize multiple and intercellular pathways at various steps to prevent DA neurons from degeneration. Molecular delineation of the mechanisms of actions is revealing new, perhaps combinational therapeutic approaches to stop the progression of DA degeneration.

2 Review The NFE2L2 rs35652124 polymorphism and the risk of Parkinson's disease: a systematic review and meta-analysis. 2016

Zhu, Mengru / Zhou, TingTing / Zu, Guo / Liang, ZhanHua. ·aThe Second Department of Clinical Medicine, China Medical University, Shenyang bDepartment of Neurology, The First Affiliated Hospital of Dalian Medical University cDepartment of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. ·Neuroreport · Pubmed #27306592.

ABSTRACT: The relationship between the nuclear factor erythroid-derived 2-like 2 (NFE2L2) rs35652124 (A/G) polymorphism and the risk of Parkinson's disease (PD) is controversial. To evaluate the association of the NFE2L2 rs35652124 polymorphism with the risk of PD, a meta-analysis was carried out. A total of 2264 PD cases and 2582 controls were included in the meta-analysis on the basis of strict inclusion and exclusion criteria. The pooled odds ratio (OR) and 95% confidence interval were calculated to assess the genetic association between the NFE2L2 rs35652124 polymorphism and the risk of PD. There was no significant association between rs35652124 and PD (G vs. A: OR=1.001, P=0.986; GG vs. AA: OR=1.026, P=0.785; GA vs. AA: OR=1.023, P=0.786; GG+GA vs. AA: OR=1.224, P=0.070; GG vs. GA+AA: OR=0.994, P=0.926). The data of our meta-analysis indicate that the G allele, GG, and GA genotype of the rs35652124 (A/G) polymorphism were not associated with the risk of PD.

3 Article A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. 2018

Zhou, Ting / Kim, Tae Wan / Chong, Chi Nok / Tan, Lei / Amin, Sadaf / Sadat Badieyan, Zohreh / Mukherjee, Suranjit / Ghazizadeh, Zaniar / Zeng, Hui / Guo, Min / Crespo, Miguel / Zhang, Tuo / Kenyon, Reyn / Robinson, Christopher L / Apostolou, Effie / Wang, Hui / Xiang, Jenny Zhaoying / Evans, Todd / Studer, Lorenz / Chen, Shuibing. ·Department of Surgery, Weill Cornell Medical College, 1300 York Ave, New York, 10065, NY, USA. · The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, 10065, USA. · Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY, 10065, USA. · School of Public health, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200000, China. · Genomic Resource Core Facility, Weill Cornell Medical College, 1300 York Ave, New York, 10065, NY, USA. · Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, 10065, NY, USA. · The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, New York, NY, 10065, USA. studerl@mskcc.org. · Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, NY, 10065, USA. studerl@mskcc.org. · Department of Surgery, Weill Cornell Medical College, 1300 York Ave, New York, 10065, NY, USA. shc2034@med.cornell.edu. · Department of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, 10065, NY, USA. shc2034@med.cornell.edu. ·Nat Commun · Pubmed #30446643.

ABSTRACT: Common disorders, including diabetes and Parkinson's disease, are caused by a combination of environmental factors and genetic susceptibility. However, defining the mechanisms underlying gene-environment interactions has been challenging due to the lack of a suitable experimental platform. Using pancreatic β-like cells derived from human pluripotent stem cells (hPSCs), we discovered that a commonly used pesticide, propargite, induces pancreatic β-cell death, a pathological hallmark of diabetes. Screening a panel of diverse hPSC-derived cell types we extended this observation to a similar susceptibility in midbrain dopamine neurons, a cell type affected in Parkinson's disease. We assessed gene-environment interactions using isogenic hPSC lines for genetic variants associated with diabetes and Parkinson's disease. We found GSTT1

4 Article (-)-Epigallocatechin-3-gallate modulates peripheral immunity in the MPTP-induced mouse model of Parkinson's disease. 2018

Zhou, Tingting / Zhu, Mengru / Liang, Zhanhua. ·Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China. · Department of Plastic Surgery, China Medical University, Shenyang, Liaoning 110001, P.R. China. ·Mol Med Rep · Pubmed #29363729.

ABSTRACT: (-)-Epigallocatechin-3-gallate (EGCG) is the most widely studied catechin in green tea and has been identified to regulate immune function. The objective of the present study was to explore the possible application of EGCG in the treatment of Parkinson's disease (PD) by examining its effects on the peripheral immune system in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)‑induced PD mouse model. The results demonstrated that EGCG treatment restored the movement behavior of the mice impaired by MPTP, and protected tyrosine hydroxylase‑positive cells in the substantia nigra pars compacta region from MPTP toxicity. Flow cytometric analysis indicated that the ratio of CD3+CD4+ to CD3+CD8+ T lymphocytes in the peripheral blood increased in MPTP‑treated mice following treatment with EGCG, and EGCG reduced expression of inflammatory factors tumor necrosis factor‑α and interleukin‑6 in serum. The present findings indicated that EGCG serves neuroprotective effects in an MPTP‑induced PD mice model and may exert this through modulating peripheral immune response.

5 Article Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease. 2016

Zhou, Tingting / Zu, Guo / Zhang, Xiaogang / Wang, Xi / Li, Shao / Gong, Xiaoyang / Liang, Zhanhua / Zhao, Jie. ·Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Da'lian 116011, China. · Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Da'lian 116023, China. · Department of Physiology, Dalian Medical University, Da'lian 116044, China. · Department of Traditional Chinese Medicine, The First Affiliated Hospital of Dalian Medical University, Da'lian 116011, China. · Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Da'lian 116011, China. Electronic address: zhanhualiangdl@163.com. · Department of Physiology, Dalian Medical University, Da'lian 116044, China. Electronic address: dlzhaoj@163.com. ·Neuropharmacology · Pubmed #26525190.

ABSTRACT: Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has low toxicity and has been shown to have neuroprotective effects. The objectives of the present study were to explore the potential of the application of Rg1 for the treatment of Parkinson's disease (PD) and to determine whether its neuroprotective effects are exerted through the Wnt/β-catenin signaling pathway by using in vivo and in vitro models of PD. In the in vivo study, Rg1 treatment ameliorated the behavioral deficits of "Pole test", and reduced dopaminergic cell loss that were induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) in a dose-dependent manner in an in vivo model of PD. In the in vitro study, cell viability was increased and cell apoptosis induced by 1-methyl-4-phenylpyridinium(MPP+) was decreased by Rg1 pretreatment. Rg1 induced protective effects on the protein and mRNA expression levels of markers of the Wnt/β-catenin signaling pathway in both the in vivo and the in vitro studies, and these neuroprotective effects were blocked by DKK1 in the in vitro study. Our results provide evidence that Rg1 has neuroprotective effects in both in vivo and in vitro PD models, and these effects act through the Wnt/β-catenin signaling pathway. Taken together, these results indicate that Rg1 may exert therapeutic effects on PD via the Wnt/β-catenin signaling pathway and may therefore provide a novel approach for the treatment of PD.

6 Article Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease. 2015

Zhou, Ting-Ting / Zu, Guo / Wang, Xi / Zhang, Xiao-Gang / Li, Shao / Liang, Zhan-Hua / Zhao, Jie. ·Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. · Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China. · Department of Physiology, Dalian Medical University, Dalian 116044, China. · Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address: zhanhualiangdl@163.com. · Department of Physiology, Dalian Medical University, Dalian 116044, China. Electronic address: dlzhaoj@163.com. ·Int Immunopharmacol · Pubmed #26548343.

ABSTRACT: Ginsenoside Rg1, one of the biologically active ingredients of ginseng, has been considered to be a candidate neuroprotective drug. The objective of the study was to study the protective effects of Rg1 through the peripheral and central inflammation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model. Rg1 treatment protected TH-positive cells in the SNpc region from MPTP toxicity measured with immunofluoresence. The protein expression levels of TH in the SNpc region of MPTP-induced mice following treatment with Rg1 were higher than MPTP-induced mice which were tested with Western blot. The ratio of CD3(+)CD4(+) to CD3(+)CD8(+) T cells and CD4(+)CD25(+)Foxp3(+) regulatory T cells in the blood increased in MPTP-induced mice following treatment with Rg1 which were detected by flow cytometry analysis. Moreover, Rg1 reduced the serum concentrations of proinflammatory cytokines TNF-α, IFN-γ, IL-1β and IL-6 which were tested with enzyme-linked immunosorbent assay (ELISA). In addition, Rg1 inhibited the activation of microglia and reduced the infiltration of CD3(+) T cells into the SNpc region which were measured by immunofluorescence. Our results indicated that Rg1 may represent a promising drug for the treatment of PD via the regulation of the peripheral and central inflammation.

7 Article Glycosylation of the sodium channel β4 subunit is developmentally regulated and involves in neuritic degeneration. 2012

Zhou, Ting-ting / Zhang, Zhen-wei / Liu, Jun / Zhang, Jian-peng / Jiao, Bing-hua. ·Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China. ·Int J Biol Sci · Pubmed #22553463.

ABSTRACT: Aberrant protein glycosylation plays major roles in neurodegenerative diseases, including Parkinson's disease (PD). Glycoproteomics showed that the glycosylation of sodium channel β4 was significantly increased in human brain tissue. β4-specific antibodies reacted in immunoblot assays with the 35- and 38-kDa bands from the membrane fractions isolated from neonatal PD transgenic mice but only with the 35-kDa band of the neonatal wild-type mice. The size of the 38-kDa immunoreactive protein is in close agreement with previously reported, suggesting heavy glycosylation of this protein in adult wild-type and neonatal PD transgenic brain tissues. However, the neonatal wild-type mice membrane fractions only contained the 35-kDa immunoreactive protein, and the additional 38-kDa band was not shown until postnatal day 7. Enzymatic deglycosylation of the membrane preparations only converted the 38-kDa band into a faster migrating protein, which was consistent with heavy glycosylation of this protein. The glycosylated state of β4 was developmentally regulated and was altered in disease state. Neurite outgrowth assay demonstrated that overexpression of deglycosylated mutant β4-MUT accelerated neurite extension and increased the number of filopodia-like protrusions, when compared with β4-WT and the vector. These results suggest that extensive glycosylation of β4 subunit play roles in morphological changes, and the altered glycosylation may be involved in the pathogenesis of PD.