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Psoriasis: HELP
Articles by Mauro D'Amato
Based on 3 articles published since 2008
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Between 2008 and 2019, M. D'Amato wrote the following 3 articles about Psoriasis.
 
+ Citations + Abstracts
1 Article Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 2016

Ellinghaus, David / Jostins, Luke / Spain, Sarah L / Cortes, Adrian / Bethune, Jörn / Han, Buhm / Park, Yu Rang / Raychaudhuri, Soumya / Pouget, Jennie G / Hübenthal, Matthias / Folseraas, Trine / Wang, Yunpeng / Esko, Tonu / Metspalu, Andres / Westra, Harm-Jan / Franke, Lude / Pers, Tune H / Weersma, Rinse K / Collij, Valerie / D'Amato, Mauro / Halfvarson, Jonas / Jensen, Anders Boeck / Lieb, Wolfgang / Degenhardt, Franziska / Forstner, Andreas J / Hofmann, Andrea / Anonymous3910861 / Anonymous3920861 / Anonymous3930861 / Anonymous3940861 / Anonymous3950861 / Schreiber, Stefan / Mrowietz, Ulrich / Juran, Brian D / Lazaridis, Konstantinos N / Brunak, Søren / Dale, Anders M / Trembath, Richard C / Weidinger, Stephan / Weichenthal, Michael / Ellinghaus, Eva / Elder, James T / Barker, Jonathan N W N / Andreassen, Ole A / McGovern, Dermot P / Karlsen, Tom H / Barrett, Jeffrey C / Parkes, Miles / Brown, Matthew A / Franke, Andre. ·Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. · Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK. · Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK. · Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. · Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea. · Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. · Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. · Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA. · Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA. · Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. · Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. · Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. · Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. · K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. · Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. · Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway. · Department of Neurosciences, University of California, San Diego, La Jolla, California, USA. · Estonian Genome Center, University of Tartu, Tartu, Estonia. · Division of Endocrinology, Boston Children's Hospital, Cambridge, Massachusetts, USA. · Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, Massachusetts, USA. · University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands. · Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. · Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. · Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands. · Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden. · BioCruces Health Research Institute and Ikerbasque, Basque Foundation for Science, Bilbao, Spain. · Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. · Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. · Institute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany. · PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany. · Institute of Human Genetics, University of Bonn, Bonn, Germany. · Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. · Department of General Internal Medicine, Universitätsklinikum Schleswig-Holstein Campus Kiel, Kiel, Germany. · Department of Dermatology, University Hospital, Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany. · Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA. · Department of Radiology, University of California, San Diego, La Jolla, California, USA. · Division of Genetics and Molecular Medicine, King's College London, London, UK. · Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. · Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. · St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK. · NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. · Division of Mental Health and Addiction, Oslo University Hospital, Ullevål, Oslo, Norway. · F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA. · Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. · Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. · University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. · Institute of Health and Biomedical Innovation (IHBI), Faculty of Health, Queensland University of Technology (QUT), Translational Research Institute, Brisbane, Queensland, Australia. ·Nat Genet · Pubmed #26974007.

ABSTRACT: We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. The comorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity). In particular, the strong comorbidity between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease, which is genetically distinct from classical inflammatory bowel disease phenotypes.

2 Article IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. 2009

Einarsdottir, Elisabet / Koskinen, Lotta L E / Dukes, Emma / Kainu, Kati / Suomela, Sari / Lappalainen, Maarit / Ziberna, Fabiana / Korponay-Szabo, Ilma R / Kurppa, Kalle / Kaukinen, Katri / Adány, Róza / Pocsai, Zsuzsa / Széles, György / Färkkilä, Martti / Turunen, Ulla / Halme, Leena / Paavola-Sakki, Paulina / Not, Tarcisio / Vatta, Serena / Ventura, Alessandro / Löfberg, Robert / Torkvist, Leif / Bresso, Francesca / Halfvarson, Jonas / Mäki, Markku / Kontula, Kimmo / Saarialho-Kere, Ulpu / Kere, Juha / D'Amato, Mauro / Saavalainen, Päivi. ·Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. elisabet.einarsdottir@helsinki.fi ·BMC Med Genet · Pubmed #19175939.

ABSTRACT: BACKGROUND: Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases. METHODS: We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease. RESULTS: Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples. CONCLUSION: Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.

3 Article Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema. 2009

Liedén, A / Ekelund, E / Kuo, I-C / Kockum, I / Huang, C-H / Mallbris, L / Lee, S P / Seng, L K / Chin, G Y / Wahlgren, C-F / Palmer, C N A / Björkstén, B / Ståhle, M / Nordenskjöld, M / Bradley, M / Chua, K Y / D'Amato, M. ·Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. ·Allergy · Pubmed #19133922.

ABSTRACT: BACKGROUND: Eczema is a common chronic inflammatory skin disorder which shows strong genetic predisposition. To identify new potential molecular determinants of the disease pathogenesis, we performed a gene expression study in an eczema mouse model. This analysis identified a marked down regulation of the cornulin gene (CRNN), a member of the epidermal differentiation complex, in the eczema-like skin. We then investigated CRNN as an eczema candidate gene and studied its polymorphism and the expression in the skin of eczema patients. METHODS: An eczema-like phenotype was induced in mice by allergen (Der p2) patching. Gene expression analysis was performed with the subtractive suppression hybridization method and validated by real time PCR and the transmission disequilibrium test was used to test for genetic associations in 406 multiplex eczema families. RESULTS: Der p 2 patched mice developed a localized eczema and a Th 2 skewed systemic response. Real time PCR analysis confirmed a down regulation of CRNN mRNA in eczema-like skin in the mouse model and in human eczema. The CRNN polymorphism rs941934 was significantly associated with atopic eczema in the genetic analysis (P = 0.006), though only as part of an extended haplotype including a known associated variant (2282del4) in the filaggrin gene. CONCLUSIONS: CRNN mRNA expression is decreased in eczematous skin. Further studies are needed to verify whether the associated cornulin polymorphism contribute to the genetic susceptibility in eczema.