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Psoriasis: HELP
Articles by Anders M. Dale
Based on 2 articles published since 2008
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Between 2008 and 2019, Anders M. Dale wrote the following 2 articles about Psoriasis.
 
+ Citations + Abstracts
1 Article Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. 2017

Witoelar, Aree / Jansen, Iris E / Wang, Yunpeng / Desikan, Rahul S / Gibbs, J Raphael / Blauwendraat, Cornelis / Thompson, Wesley K / Hernandez, Dena G / Djurovic, Srdjan / Schork, Andrew J / Bettella, Francesco / Ellinghaus, David / Franke, Andre / Lie, Benedicte A / McEvoy, Linda K / Karlsen, Tom H / Lesage, Suzanne / Morris, Huw R / Brice, Alexis / Wood, Nicholas W / Heutink, Peter / Hardy, John / Singleton, Andrew B / Dale, Anders M / Gasser, Thomas / Andreassen, Ole A / Sharma, Manu / Anonymous4711037. ·Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo2Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. · Department of Clinical Genetics, Vrije Universiteit (VU) University Medical Center, Amsterdam, the Netherlands4German Center for Neurodegenerative Diseases (DZNE), Tübingen. · Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo5Multimodal Imaging Laboratory, University of California at San Diego, La Jolla. · Multimodal Imaging Laboratory, University of California at San Diego, La Jolla6Department of Radiology and Biomedical Imaging, University of California, San Francisco. · Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland. · German Center for Neurodegenerative Diseases (DZNE), Tübingen. · Department of Psychiatry, University of California at San Diego, La Jolla9Department of Psychiatry, University of Copenhagen, Copenhagen, Denmark. · Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo10Department of Medical Genetics, University of Oslo, Oslo, Norway11Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. · Multimodal Imaging Laboratory, University of California at San Diego, La Jolla12Sciences Graduate Program, University of California at San Diego, La Jolla13Department of Neurosciences, University of California at San Diego, La Jolla. · Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo. · Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. · Department of Medical Genetics, University of Oslo, Oslo, Norway11Department of Medical Genetics, Oslo University Hospital, Oslo, Norway15K. G. Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Oslo, Norway16Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway17Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway. · Multimodal Imaging Laboratory, University of California at San Diego, La Jolla15K. G. Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Oslo, Norway. · K. G. Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Oslo, Norway16Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway18Division of Gastroenterology, Institute of Medicine, University of Bergen, Bergen, Norway19Norwegian Primary Sclerosing Cholangitis (PSC) Research Center, Department of Transplantation Medicine, Oslo. · Sorbonne Universités, Université Pierre-et-Marie Curie (UPMC) Paris 06, UM 1127, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France21Institut National de la Santé et de la Récherche Médicale (INSERM), Unité 1127, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France22Centre National de la Recherche Scientifique (CNRS) UMR 7225, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France23Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France24Assistance Publique-Hôpitaux de Paris, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France. · Department of Clinical Neuroscience, National Hospital for Neurology and Neurosurgery (NHNN), University College London, London, England. · Department of Molecular Neurosciences, Institute of Neurology, University College London, London, England. · Department of Clinical Genetics, Vrije Universiteit (VU) University Medical Center, Amsterdam, the Netherlands4German Center for Neurodegenerative Diseases (DZNE), Tübingen27Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. · Rita Lila Weston Institute, University College London, London, England. · Multimodal Imaging Laboratory, University of California at San Diego, La Jolla8Department of Psychiatry, University of California at San Diego, La Jolla13Department of Neurosciences, University of California at San Diego, La Jolla29Department of Radiology, University of California at San Diego, La Jolla. · German Center for Neurodegenerative Diseases (DZNE), Tübingen27Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. · Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany30Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany. ·JAMA Neurol · Pubmed #28586827.

ABSTRACT: Importance: Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD). The post-GWAS era provides an opportunity for cross-phenotype analyses between different complex phenotypes. Objectives: To test the hypothesis that there are common genetic risk variants conveying risk of both PD and autoimmune diseases (ie, pleiotropy) and to identify new shared genetic variants and their pathways by applying a novel statistical framework in a genome-wide approach. Design, Setting, and Participants: Using the conjunction false discovery rate method, this study analyzed GWAS data from a selection of archetypal autoimmune diseases among 138 511 individuals of European ancestry and systemically investigated pleiotropy between PD and type 1 diabetes, Crohn disease, ulcerative colitis, rheumatoid arthritis, celiac disease, psoriasis, and multiple sclerosis. NeuroX data (6927 PD cases and 6108 controls) were used for replication. The study investigated the biological correlation between the top loci through protein-protein interaction and changes in the gene expression and methylation levels. The dates of the analysis were June 10, 2015, to March 4, 2017. Main Outcomes and Measures: The primary outcome was a list of novel loci and their pathways involved in PD and autoimmune diseases. Results: Genome-wide conjunctional analysis identified 17 novel loci at false discovery rate less than 0.05 with overlap between PD and autoimmune diseases, including known PD loci adjacent to GAK, HLA-DRB5, LRRK2, and MAPT for rheumatoid arthritis, ulcerative colitis and Crohn disease. Replication confirmed the involvement of HLA, LRRK2, MAPT, TRIM10, and SETD1A in PD. Among the novel genes discovered, WNT3, KANSL1, CRHR1, BOLA2, and GUCY1A3 are within a protein-protein interaction network with known PD genes. A subset of novel loci was significantly associated with changes in methylation or expression levels of adjacent genes. Conclusions and Relevance: The study findings provide novel mechanistic insights into PD and autoimmune diseases and identify a common genetic pathway between these phenotypes. The results may have implications for future therapeutic trials involving anti-inflammatory agents.

2 Article Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 2016

Ellinghaus, David / Jostins, Luke / Spain, Sarah L / Cortes, Adrian / Bethune, Jörn / Han, Buhm / Park, Yu Rang / Raychaudhuri, Soumya / Pouget, Jennie G / Hübenthal, Matthias / Folseraas, Trine / Wang, Yunpeng / Esko, Tonu / Metspalu, Andres / Westra, Harm-Jan / Franke, Lude / Pers, Tune H / Weersma, Rinse K / Collij, Valerie / D'Amato, Mauro / Halfvarson, Jonas / Jensen, Anders Boeck / Lieb, Wolfgang / Degenhardt, Franziska / Forstner, Andreas J / Hofmann, Andrea / Anonymous3910861 / Anonymous3920861 / Anonymous3930861 / Anonymous3940861 / Anonymous3950861 / Schreiber, Stefan / Mrowietz, Ulrich / Juran, Brian D / Lazaridis, Konstantinos N / Brunak, Søren / Dale, Anders M / Trembath, Richard C / Weidinger, Stephan / Weichenthal, Michael / Ellinghaus, Eva / Elder, James T / Barker, Jonathan N W N / Andreassen, Ole A / McGovern, Dermot P / Karlsen, Tom H / Barrett, Jeffrey C / Parkes, Miles / Brown, Matthew A / Franke, Andre. ·Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. · Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK. · Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK. · Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. · Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea. · Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. · Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. · Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA. · Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA. · Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. · Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. · Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. · Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. · K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. · Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. · Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway. · Department of Neurosciences, University of California, San Diego, La Jolla, California, USA. · Estonian Genome Center, University of Tartu, Tartu, Estonia. · Division of Endocrinology, Boston Children's Hospital, Cambridge, Massachusetts, USA. · Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, Massachusetts, USA. · University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands. · Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. · Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. · Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands. · Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden. · BioCruces Health Research Institute and Ikerbasque, Basque Foundation for Science, Bilbao, Spain. · Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. · Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. · Institute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany. · PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany. · Institute of Human Genetics, University of Bonn, Bonn, Germany. · Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. · Department of General Internal Medicine, Universitätsklinikum Schleswig-Holstein Campus Kiel, Kiel, Germany. · Department of Dermatology, University Hospital, Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany. · Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA. · Department of Radiology, University of California, San Diego, La Jolla, California, USA. · Division of Genetics and Molecular Medicine, King's College London, London, UK. · Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. · Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. · St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK. · NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. · Division of Mental Health and Addiction, Oslo University Hospital, Ullevål, Oslo, Norway. · F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA. · Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. · Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. · University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. · Institute of Health and Biomedical Innovation (IHBI), Faculty of Health, Queensland University of Technology (QUT), Translational Research Institute, Brisbane, Queensland, Australia. ·Nat Genet · Pubmed #26974007.

ABSTRACT: We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. The comorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity). In particular, the strong comorbidity between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease, which is genetically distinct from classical inflammatory bowel disease phenotypes.