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Psoriasis: HELP
Articles by Marie Tauber
Based on 4 articles published since 2008
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Between 2008 and 2019, M. Tauber wrote the following 4 articles about Psoriasis.
 
+ Citations + Abstracts
1 Review IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases. 2016

Tauber, Marie / Bal, Elodie / Pei, Xue-Yuan / Madrange, Marine / Khelil, Amel / Sahel, Houria / Zenati, Akila / Makrelouf, Mohamed / Boubridaa, Khaled / Chiali, Amel / Smahi, Naima / Otsmane, Farida / Bouajar, Bakar / Marrakchi, Slaheddine / Turki, Hamida / Bourrat, Emmanuelle / Viguier, Manuelle / Hamel, Yamina / Bachelez, Hervé / Smahi, Asma. ·INSERM unit U1163, Imagine Institute, Necker-Enfants Malades Hospital, Paris, France. · Department of Biochemistry, University of Cambridge, Cambridge, UK. · Department of Dermatology, CHU Oran, Oran, Algeria. · Department of Dermatology, CHU Bab El Oued, Bab el Oued, Alger, Algeria. · Central laboratory of Biology, CHU Bab El Oued, Bab el Oued, Alger, Algeria. · Department of Dermatology and the Laboratory of Immunology, Hedi Chaker Hospital, Sfax University, Sfax, Tunisia. · Department of Dermatology, AP-HP, Saint-Louis Hospital, Paris, France. · Department of Dermatology, AP-HP, Saint-Louis Hospital, Paris, France; University Paris-Diderot, Sorbonne Paris Cité, Paris, France. · INSERM unit U1163, Imagine Institute, Necker-Enfants Malades Hospital, Paris, France; Department of Dermatology, AP-HP, Saint-Louis Hospital, Paris, France; University Paris-Diderot, Sorbonne Paris Cité, Paris, France. · INSERM unit U1163, Imagine Institute, Necker-Enfants Malades Hospital, Paris, France. Electronic address: asma.smahi@inserm.fr. ·J Invest Dermatol · Pubmed #27220475.

ABSTRACT: Homozygous or compound heterozygous IL36RN gene mutations underlie the pathogenesis of psoriasis-related pustular eruptions including generalized pustular psoriasis, palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau, and acute generalized exanthematous pustular eruption. We identified two unreported IL36RN homozygous mutations (c.41C>A/p.Ser14X and c.420_426del/p.Gly141MetfsX29) in patients with familial generalized pustular psoriasis. We analyzed the impact of a spectrum of IL36RN mutations on IL-36 receptor antagonist protein by using site-directed mutagenesis and expression in HEK293T cells. This enabled us to differentiate null mutations with complete absence of IL-36 receptor antagonist (the two previously unreported mutations, c.80T>C/p.Leu27Pro, c.28C>T/p.Arg10X, c.280G>T/p.Glu94X, c.368C>G/p.Thr123Arg, c.368C>T/p.Thr123Met, and c.227C>T/p.Pro76Leu) from mutations with decreased (c.95A>G/p.His32Arg, c.142C>T/p.Arg48Trp, and c.308C>T/p.Ser113Leu) or unchanged (c.304C>T/p.Arg102Trp and c.104A>G/p.Lys35Arg) protein expression. Functional assays measuring the impact of mutations on the capacity to repress IL-36-dependent activation of the NF-κB pathway showed complete functional impairment for null mutations, whereas partial or no impairment was observed for other mutations considered as hypomorphic. Finally, null mutations were associated with severe clinical phenotypes (generalized pustular psoriasis, acute generalized exanthematous pustular eruption), whereas hypomorphic mutations were identified in both localized (palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau) and generalized variants. These results provide a preliminary basis for genotype-phenotype correlation in patients with deficiency of the IL-36Ra (DITRA), and suggest the involvement of other factors in the modulation of clinical expression.

2 Article Partial clinical response to anakinra in severe palmoplantar pustular psoriasis. 2014

Tauber, M / Viguier, M / Alimova, E / Petit, A / Lioté, F / Smahi, A / Bachelez, H. ·Université Paris Diderot-Sorbonne, Paris Cité, Department of Dermatology, Hôpital Saint-Louis, APHP, 1 avenue Claude-Vellefaux, 75475 Cedex 10, Paris, France; Laboratory of genetics of autoinflammatory diseases, Université Paris Diderot-Sorbonne, Paris Cité, Institut Imagine, Hôpital Necker-Enfants Malades, Paris, France. ·Br J Dermatol · Pubmed #24684162.

ABSTRACT: BACKGROUND: Palmoplantar pustular psoriasis is a clinical psoriasis variant characterised by a high impact on quality of life and poor response to biologics approved for plaque type psoriasis.The recombinant interleukin-1 (IL-1) receptor antagonist anakinra has been recently used for the treatment of isolated refractory cases of generalised pustular psoriasis with contrasted results. OBJECTIVES: To report the clinical response in two patients treated with anakinra as salvage therapy in two patients with severe palmoplantar pustular psoriasis refractory to currently available antipsoriatic systemic therapies. METHODS: Anakinra was given subcutaneously at the daily dose of 100 mg, and clinical response was evaluated using the palmoplantar psoriasis area and severity index (PPPASI). RESULTS: Only partial and transient responses were observed in both patients, who had to stop anakinra due to lack of efficacy and to side effects. CONCLUSION: Anakinra appears to provide only partial clinical improvement in refractory palmoplantar pustular psoriasis. Prospective clinical studies on larger populations are warranted to investigate more accurately both efficacy and safety of IL-1-inhibiting strategies in pustular psoriasis.

3 Minor Authorship selection in industry-sponsored publications of dermatology clinical trials. 2017

Tauber, M / Paul, C. ·Dermatology Department, Larrey Hospital, Toulouse University, 24 Chemin de Pouvourville, 31059, Toulouse CEDEX 9, France. ·Br J Dermatol · Pubmed #28303566.

ABSTRACT: -- No abstract --

4 Minor Alopecia areata developing during ustekinumab therapy: report of two cases. 2013

Tauber, Marie / Beneton, Nathalie / Reygagne, Pascal / Bachelez, Hervé / Viguier, Manuelle. ·Department of Dermatology. · Department of Dermatology, Centre Hospitalier du Mans, France. · Centre Sabouraud, Hôpital Saint-Louis, Paris VII Denis-Diderot University, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. ·Eur J Dermatol · Pubmed #24334218.

ABSTRACT: -- No abstract --