Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Pulmonary Sclerosing Hemangioma HELP
Based on 91 articles published since 2010
||||

These are the 91 published articles about Pulmonary Sclerosing Hemangioma that originated from Worldwide during 2010-2020.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4
1 Review Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature. 2019

Wang, Zhao / Yang, Mai-Qing / Huang, Wen-Jing / Zhang, Di / Xu, Hong-Tao. ·Department of Pathology, the First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang. · Department of Pathology, General Hospital of Heilongjiang Land Reclamation Bureau, Harbin. · Department of Pathology, Changyi People's Hospital, Changyi, China. ·Medicine (Baltimore) · Pubmed #30702609.

ABSTRACT: RATIONALE: Sclerosing pneumocytoma accompanied with other type of tumor in one patient is very rare. Here, we report a case of a sclerosing pneumocytoma mixed with a typical carcinoid tumor in a same neoplasm. PATIENT CONCERNS: A 55-year-old woman incidentally detected a space-occupying lesion of right lung in routine health examination. The patient was asymptomatic and there were no positive findings in routine laboratory examination, physical examination, and pulmonary function test. Computed tomography revealed a solitary round mass in the middle lobe of the right lung. DIAGNOSIS: The lesion was diagnosed as a sclerosing pneumocytoma accompanied with a typical carcinoid tumor of the right lung. INTERVENTION: The patient underwent thoracoscopic lobectomy in our hospital. OUTCOMES: The postoperative course was uneventful. LESSONS: This case is rare and noteworthy for a lesion containing two different types of neoplasms, which may cause diagnostic difficulties.

2 Review A rare case of pulmonary sclerosing hemagioma with lymph node metastasis and review of the literature. 2015

Xu, Hai-Miao / Zhang, Gu. ·Department of Pathology, Zhejiang Cancer Hospital Hangzhou, Zhejiang Province, P. R. China. ·Int J Clin Exp Pathol · Pubmed #26339444.

ABSTRACT: Pulmonary sclerosing hemagioma (SH) is an uncommon tumor with malignance potential. Clinically this disease is regarded as benign but extremely rare cases can have lymph node metastasis. Up to date, there have been only very few reports concerning SH with lymph node metastasis. In this paper we reported one pulmonary SH case with lymph node metastasis and additionally overviewed the clinical and pathological features of SH. A young-aged female was found incidentally to have a nodule in the right upper lung. This patient presented no cough, no hemoptysis and chest pain. Computed tomography (CT) scan indicated a large mass in the right upper lung and enlarged lymph nodes in the right hilum. The patient underwent lobectomy of the right upper lung. Histologically, the tumor demonstrated typical features of SH and was consisted of angiomatoid areas, sclerosis, papillary structures lined with cuboidal cells and sheets of round to polygonal cells. Polygonal cells in some solid areas presented abnormal enlarged nuclei and increased karyoplasmic ratio; tumor giant cells were noted; whereas mitosis was not observed. One peribronchial lymph node was noted for SH metastasis and the metastatic tissue were consisted of polygonal cells. Immunohistochemistry (IHC) revealed that both surface-lining cuboidal and polygonal cells expressed EMA and thyroid transcription factor 1 (TTF-1), but were negative for CD34, VIII factor, CD68 and Claratinin. The polygonal cells showed relatively higher expression of Ki-67 and p53 than the surface-lining cells. Postoperatively, the patient received no chemotherapy or radiotherapy and no recurrence 2 years after surgery was noted.

3 Review Sclerosing Pneumocytoma with a Wax-and-Wane Pattern of Growth: A Case Report on Computed Tomography and Magnetic Resonance Imaging Findings and a Literature Review. 2015

Kim, Yong Pyo / Lee, Sungsoo / Park, Heae Surng / Park, Chul Hwan / Kim, Tae Hoon. ·Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea. · Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea. · Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea. ·Korean J Radiol · Pubmed #26175598.

ABSTRACT: Sclerosing pneumocytoma (SP) of the lung is a rare benign neoplasm. Here, we describe an unusual presentation of SP with a wax-and-wane pattern of growth in a 47-year-old woman. Tumor diameter decreased over a 3-year follow-up period and then increased on serial follow-up computed tomography scans. The mass showed high signal intensity on both T1- and T2-weighted chest magnetic resonance imaging (MRI) and early enhancement with a plateau on dynamic MRI. We speculate that intratumoral bleeding and resorption processes accounted for the changes in tumor size.

4 Review Fine-needle aspiration diagnosis of sclerosing hemangioma (pneumocytoma): report of a case and review of the literature. 2014

Dettrick, Andrew / Meikle, Anne / Fong, Kwun M. ·Department of Anatomical Pathology, The Prince Charles Hospital, Chermside, Australia. ·Diagn Cytopathol · Pubmed #22645055.

ABSTRACT: Sclerosing hemangioma (pneumocytoma) is a rare benign lung tumor with uncertain histogenesis but characteristic histology. Reports of the cytopathology of this tumor are even rarer with only a handful of cases in the literature--many of these incorrectly diagnosed by cytology initially. Herein, we describe a case of sclerosing hemangioma diagnosed prima facie by fine-needle aspiration cytology. A cell block preparation with accompanying immunohistochemistry was instrumental in making the diagnosis. A review of the literature is also presented.

5 Review Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. 2013

Salemis, Nikolaos S / Seretis, Charalampos / Nakos, Georgios / Kantounakis, Ioannis / Stoumpos, Charalampos / Spiliopoulos, Kyriakos. ·Breast Unit, Army General Hospital, Athens, Greece. ·Breast Dis · Pubmed #23838116.

ABSTRACT: Pulmonary sclerosing hemangioma (PSH) is a rare tumor accounting for 0.2-1% of all primary lung tumors. Simultaneous occurrence of PSH with breast cancer has very rarely been reported in the literature. We describe here a case of simultaneous occurrence of PSH with breast cancer. A pathological diagnosis of PSH was confirmed by computed tomography (CT)-guided biopsy. Due to the patient's poor performance status and the benign nature of PSH, surgical excision was not considered and the patient was managed conservatively with regular follow-up. Although surgical excision is the preferred treatment for PSH, conservative management may be a reasonable option in carefully selected patients.

6 Review Microscopic sclerosing hemangioma diagnosed by histopathological examination after lung cancer surgery. 2011

Goto, Taichiro / Maeshima, Arafumi / Kato, Ryoichi. ·Department of General Thoracic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan. taichiro@1997.jukuin.keio.ac.jp ·Ann Thorac Cardiovasc Surg · Pubmed #21881377.

ABSTRACT: A 44-year-old woman underwent surgery for lung cancer. Although preoperative computed tomography did not reveal a tiny nodule, pathological examination of the background lung showed that type II pneumocyte-like tumor cells grew papillary in an area of approximately 2.3 × 1.2 mm. This lesion exhibited hemorrhage, hemosiderosis, calcification, and varying degrees of fibrosis, leading to the diagnosis of sclerosing hemangioma. This is the first reported case of microscopic sclerosing hemangioma undetectable by chest computed tomography.

7 Review Sclerosing haemangioma of the lung - an unusual multifocal presentation. 2010

Rosliza, G / Hairulfaizi, H / Joanna, O S M / Zamrin, D M / Ramzisham, A R M. ·Universiti Kebangsaan Malaysia Medical Centre, Department of Surgery, Division of Cardiothoracic Surgery, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia. drramzi@ymail.com. ·Med J Malaysia · Pubmed #23756801.

ABSTRACT: We present a rare case of a multifocal sclerosing haemangioma of the lung in a 49-year-old lady. A left pneumonectomy with complete excision of the tumour seems to be the curative treatment. The recent literature on this unusual presentation is reviewed.

8 Review So-called sclerosing hemangioma of lung: current concept. 2010

Kalhor, Neda / Staerkel, Gregg A / Moran, Cesar A. ·Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, USA. nkalhor@mdanderson.org ·Ann Diagn Pathol · Pubmed #20123460.

ABSTRACT: Sclerosing hemangioma of the lung is a rare neoplasm with polymorphic histologic features. Despite various patterns, there are 2 unifying cellular components: "surface cells" and "round cells." Although histogenesis has been debated for decades, most ultrastructural, immunocytochemical, and molecular studies strongly indicate a neoplastic epithelial derivation for both cellular components. Herein, we present a review of sclerosing hemangioma and summarize the essential data regarding histologic, cytologic, and ancillary findings of this distinctive pulmonary neoplasm.

9 Article Multiple sclerosing hemangioma of the right lung in a 23-year-old female patient: A case report and review of the literature. 2020

Luo, Han / Ma, Lijie / Chen, Yihua / Zhang, Tingxiu / Peng, Daqing / Li, Zhiwei / Dan, Xiaoping / Xiao, Zhenliang / Chen, Zhang. ·Department of Pulmonary and Critical Care Medicine, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China. · Department of Pathology, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China. ·Mol Clin Oncol · Pubmed #32064104.

ABSTRACT: Pulmonary sclerosing hemangioma (PSH) is a relatively uncommon benign tumor of the lung, predominantly affecting young and middle-aged women. In the majority of the patients, PSH is incidentally found on physical examination and typically presents as a solitary nodule with smooth borders, as it is generally asymptomatic or lacks typical symptoms. In the present case, a 23-year-old woman was incidentally diagnosed with pulmonary nodules during routine physical examination and reported suffering from intermittent fevers for >2 months. The patient received antituberculosis therapy for 1 year; however, a computed tomography imaging examination revealed that the lesions had progressed. Finally, the patient underwent thoracoscopic lung biopsy followed by histopathological examination and the lesions were diagnosed as multiple sclerosing hemangioma. The aim of the present study was to review the relevant literature in order to improve our understanding of PSH.

10 Article Concomitance of pulmonary spindle cell carcinoma and sclerosing pneumocytoma in a woman: A case report. 2019

LuLu, Xu / Jian, Shu. ·Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. ·Medicine (Baltimore) · Pubmed #31861007.

ABSTRACT: RATIONALE: Pulmonary spindle cell carcinoma (PSCC) is a rare subset of pulmonary sarcomatoid carcinoma. PSCC is aggressive and has a poor prognosis. Pulmonary sclerosing pneumocytoma (PSP) is an asymptomatic slow-growing benign tumor, which usually occurs in middle-aged women. PATIENT CONCERNS: Herein, we report a case of solitary PSCC, occurring concomitantly with PSP in a 74-year-old woman. The patient visited our institution with productive purulent cough, dyspnea after activity, and hemoptysis. Enhanced computed tomography revealed an inhomogeneous enhanced mass with central low-attenuation in the right upper lobe (RUL). The mass located in the right lower lobe (RLL) exhibited homogeneous enhancement. DIAGNOSIS: These lesions were subsequently diagnosed as PSCC in the RUL and PSP in the RLL, following postoperative pathological examination. INTERVENTIONS: We performed lobectomy for the RUL and wedge resection for the RLL in one procedure. OUTCOMES: The patient did not experience complications after surgery. No radiological evidence of recurrence was observed on follow-up computed tomography performed within 7 months after the procedure. LESSONS: This case fully reflects the importance of the differential preoperative diagnosis of benign and malignant solitary pulmonary nodules. However, a rare and aggressive malignant tumor may have imaging features typical of a lung abscess, which should be treated carefully.

11 Article Sclerosing pneumocytoma: Case report of a rare endobronchial presentation. 2019

Khanna, Akriti / Alshabani, Khaled / Mukhopadhyay, Sanjay / Lam, Louis / Ghosh, Subha. ·Diagnostic Radiology, Imaging Institute. · Respiratory Institute, Cleveland Clinic. · Department of Pathology, Cleveland Clinic. ·Medicine (Baltimore) · Pubmed #30985653.

ABSTRACT: RATIONALE: Sclerosing pneumocytoma is a rare benign lung neoplasm seen in middle aged adults with a female predominance. Originally thought to be vascular in origin, this rare entity is now understood to be epithelial in nature. On imaging, sclerosing pneumocytoma manifests as a well circumscribed nodule or mass, often juxtapleural in location. On histopathology, sclerosing pneumocytoma is composed of cuboidal "surface cells" and round "stromal cells," both of which show nuclear staining for thyroid transcription factor-1 (TTF-1). Here we review the existing literature on sclerosing pneumocytoma and present a case of sclerosing pneumocytoma in a highly unusual endobronchial location. PATIENT CONCERNS: This case is a 43 year old woman who presented with chronic cough. DIAGNOSIS: Imaging revealed a right upper lobe nodule with an endobronchial component. INTERVENTIONS AND OUTCOMES: Endoscopic biopsy was performed, and pathologic diagnosis was confirmed. LESSONS: Although extremely rare, endobronchial presentation of sclerosing pneumocytoma is possible, and should remain on the differential for patients with endobronchial pulmonary lesions. Pathologic tissue analysis is necessary to confirm this uncommon diagnosis.

12 Article Symptomatic pulmonary sclerosing hemangioma: a rare case of a solitary pulmonary nodule in a woman of advanced age. 2019

Yuan, Zhu-Qing / Wang, Qian / Bao, Min. ·1 Department of Respiratory Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Hubei, China. · 2 Department of Intensive Care Unit, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Hubei, China. ·J Int Med Res · Pubmed #30971157.

ABSTRACT: BACKGROUND: Pulmonary sclerosing hemangioma (PSH) is a rare tumor that usually develops in middle-aged Asian women. PSH has four histological types (hemorrhagic, sclerotic, solid, and papillary) and often grows slowly in a lower lobe of the lung. Preoperative misdiagnosis frequently occurs because of the absence of specific clinical manifestations and imaging findings. Few reports have described PSH in women of advanced age. Case presentation: A 75-year-old woman presented to our hospital in China with a 5-day history of productive cough and intermittent hemoptysis. Computed tomography indicated bronchiectasis and a large mass in the left inferior lobe of the lung. Treatment of the bronchiectasis provided no symptom relief. The hemoptysis resolved following left lower pulmonary lobectomy, and PSH was pathologically diagnosed following surgery. At the time of this writing (after 6 months of follow-up), the tumor had not recurred, no metastases had been detected, and close follow-up was ongoing. CONCLUSIONS: Both bronchiectasis and PSH can cause hemoptysis. This case demonstrates that PSH should be included as a differential diagnosis of hemoptysis in women of advanced age. For patients with chronic hemoptysis, the diagnosis of PSH should be considered if the therapeutic effect of bronchiectasis is poor.

13 Article A 58-Year-Old Woman With Back Pain and an Unusual Diagnosis. 2019

Bohm, Avri / Asiry, Saeed / Hasanovic, Adnan / Machnicki, Stephen. ·Department of Radiology, Lenox Hill Hospital, New York, NY. Electronic address: ABohm@northwell.edu. · Department of Pathology, Lenox Hill Hospital, New York, NY. · Department of Radiology, Lenox Hill Hospital, New York, NY. ·Chest · Pubmed #30732701.

ABSTRACT: CASE PRESENTATION: A 58-year-old postmenopausal woman presented to her primary care physician with lower back pain. She denied respiratory symptoms. Her medical history is significant for hypertension, hyperlipidemia, and prediabetes. Her surgical history consists of a tonsillectomy and a remote dilatation and curettage procedure. She denied a history of smoking, alcohol use, or recreational drug use. A review of systems was otherwise negative.

14 Article Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital. 2019

Lovrenski, Aleksandra / Vasilijević, Milena / Panjković, Milana / Tegeltija, Dragana / Vučković, Dejan / Baroš, Ilija / Lovrenski, Jovan. ·Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. aleksandra.lovrenski@mf.uns.ac.rs. · Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. milena.vasilijevic@uns.ac.rs. · Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. milana.panjkovic@mf.uns.ac.rs. · Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. dragana.tegeltija@mf.uns.ac.rs. · Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. dejan.vuckovic@mf.uns.ac.rs. · Department of Pathology, University Clinical Center of Republic of Srpska, 78000 Banja Luka, Republic of Srpska, Bosnia and Herzegovina. ilija.baros@med.unibl.org. · Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. jovan.lovrenski@mf.uns.ac.rs. ·Medicina (Kaunas) · Pubmed #30691016.

ABSTRACT:

15 Article A case of pulmonary sclerosing pneumocytoma in the hilar lesion. 2019

Ikeda, Masaki / Okada, Yuki / Hagiwara, Kiyohiko / Murata, Yoshitake / Kanayama, Tomohiro / Hara, Akira / Fujinaga, Takuji. ·Department of Thoracic Surgery, Nagara Medical Center, Nagara 1300-7, Gifu, 502-8558, Japan. imsk117@kuhp.kyoto-u.ac.jp. · Department of Thoracic Surgery, Nagara Medical Center, Nagara 1300-7, Gifu, 502-8558, Japan. · Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan. ·Gen Thorac Cardiovasc Surg · Pubmed #30488193.

ABSTRACT: Pulmonary sclerosing pneumocytoma (PSP) arising from the hilar lesion is extremely rare. We report an asymptomatic 70-year-old female with a thoracic tumor of unknown origin. Contrast-enhanced chest tomography showed a poorly and heterogeneously enhanced 40-mm tumor compressing the left upper lobe, bronchus, and pulmonary arteries. Positron-emission tomography did not detect abnormal integration in the tumor. Surgical resection was planned to confirm diagnosis and avoid further compression on the structures. Intraoperative findings revealed a dark red-colored tumor, projecting from the left upper lobe in the hilar lesion. Left upper lobectomy was performed through video-assisted thoracoscopic surgery to achieve complete resection and avoid contact bleeding. Immunohistochemical examination revealed the presence of PSP.

16 Article Tail sign: Pulmonary sclerosing pneumocytoma. 2018

Han, Jason / Xiang, Hao / Ridley, William E / Ridley, Lloyd J. ·Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia. · University of New England, Armidale, New South Wales, Australia. · Medical Imaging, University of Sydney, Sydney, New South Wales, Australia. ·J Med Imaging Radiat Oncol · Pubmed #30309107.

ABSTRACT: -- No abstract --

17 Article Pulmonary Sclerosing Pneumocytoma. 2018

Rivera, Estefania / Gesthalter, Yaron / VanderLaan, Paul / Parikh, Mihir S. ·Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. · Department of Interventional Pulmonary Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco (UCSF) San Francisco, CA. ·J Bronchology Interv Pulmonol · Pubmed #30247298.

ABSTRACT: -- No abstract --

18 Article A Challenge: Pulmonary Sclerosing Haemangioma. 2018

Li, Tong-Tong / Yan, Xu / Zhou, Tong / Yu, Zhen-Xiang. ·Department of Respiration, The First Hospital of Jilin University, Changchun, Jilin 130021, China. · Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. · Department of Endocrinology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. ·Chin Med J (Engl) · Pubmed #30147108.

ABSTRACT: -- No abstract --

19 Article None 2018

Jiang, Lei / Huang, Yan / Tang, Qiying / Zhao, Qingping / Li, Yuan / Wu, Xiaodong / Wang, Huoqiang. ·Department of Nuclear Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China. · Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China. · Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200233, P.R. China. ·Oncol Lett · Pubmed #29930720.

ABSTRACT: The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (

20 Article Coexistence of glandular papilloma and sclerosing pneumocytoma in the bronchiole. 2018

Kitawaki, Yuko / Fujishima, Fumiyoshi / Taniuchi, Shinji / Saito, Ryoko / Nakamura, Yasuhiro / Sato, Ryoko / Aoyama, Yayoi / Onodera, Yoshiaki / Inoshita, Naoko / Matsuda, Yasushi / Watanabe, Mika / Sasano, Hironobu. ·Department of Anatomic Pathology, Tohoku University Graduate School of Medicine. · Division of Pathology, Tohoku University Hospital. · Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai. · Department of Pathology, Toranomon Hospital, Tokyo. · Department of Thoracic Surgery, Tohoku University Hospital. · Research Division for Development of Anti-Infective Agents, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. ·Pathol Int · Pubmed #29696743.

ABSTRACT: Both glandular papilloma (GP) and sclerosing pneumocytoma (SP) are rare tumors in the lung. We herein report an extremely rare case of coexistence of these two uncommon tumors. The patient was a 40-year-old Japanese woman with no chief complaint. A solitary nodule of the lung was detected using chest computed tomography. The transbronchial biopsy revealed that the tumor histologically corresponded to GP. The patient subsequently underwent partial resection of the right upper lobe. Histological examination of the resected specimens further revealed that the mass contained two different and independent elements and displayed typically histological features of GP and SP. Molecular analysis further revealed the presence of BRAF V600E and AKT1 E17K mutations in GP, whereas only AKT1 mutation was detected in SP. To our knowledge, this is the first case of coexistence of GP and SP in the bronchiole harboring common AKT1 mutation and different BRAF V600E mutational status.

21 Article [On the histo- and morphogenesis of sclerosing pneumocytoma and its diagnostic criteria]. 2018

Dvorakovskaya, I V / Novitskaya, T A / Mazitova, F M / Skryabin, S A / Gordeladze, A S. ·Research Institute of Pulmonology, Acad. I.P. Pavlov Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia; Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, St. Petersburg, Russia. · Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, St. Petersburg, Russia; P.A. Bayandin Murmansk Regional Clinical Hospital, Murmansk, Russia. · Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, St. Petersburg, Russia. · P.A. Bayandin Murmansk Regional Clinical Hospital, Murmansk, Russia. · Research Institute of Pulmonology, Acad. I.P. Pavlov Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia, Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, St. Petersburg, Russia, P.A. Bayandin Murmansk Regional Clinical Hospital, Murmansk, Russia. ·Arkh Patol · Pubmed #29460895.

ABSTRACT: The paper presents the data available in the literature on the pathogenesis, clinical and morphological, histological and immunohistochemical features of pulmonary sclerosing pneumocytoma (SP). The paper gives the detailed histological and immunohistochemical characteristics of 6 SP cases. The need for the differential diagnosis of SP is determined by the features and complexity of their histo- and morphogenesis within a single tumor and a complex diagnostic study.

22 Article Genome profile in a extremely rare case of pulmonary sclerosing pneumocytoma presenting with diffusely-scattered nodules in the right lung. 2018

Fan, Xiangshan / Lin, Ling / Wang, Jianjun / Wang, Yu / Feng, Anning / Nie, Ling / Wu, Hongyan / Meng, Fanqing / Xu, Haodong. ·a Department of Pathology , Nanjing Drum Tower Hospital, the affiliated Hospital of Nanjing University Medical School , Nanjing , Jiangsu Province , China. · b Department of Medicine , Shanghai Biotecan Pharmaceuticals Co., Ltd. , Pudong New District , Shanghai , China. · c Department of Pathology & Laboratory Medicine , David Geffen School of Medicine, UCLA , Los Angeles , California , USA. ·Cancer Biol Ther · Pubmed #29236566.

ABSTRACT: BACKGROUND: Pulmonary sclerosing pneumocytoma (PSP) typically presents solitary and peripheral mass, while only rarely cases display unusual multiple lesions. We reported a extremely rare case of PSP with diffusely-scattered nodules in the right lung. CASE PRESENTATION: Diffusely round-shaped nodular shadows in the right lung were found by CT scan in a 31-year-old Chinese woman. The patient undergone the right pneumnectomy. Grossly, numerous small nodules, up to 2.5 cm in greatest dimension were identified in the upper, middle and lower lobes of the right lung. Histologically, the tumor presented the typical features of PSP, with a variable proportion of solid, sclerotic and papillary patterns. Immunohistochemical staining further revealed that cuboidal surface epithelial cells were positive for TTF-1, EMA, AE1/3 and vimentin (partially), and round or polygonal cells expressed TTF-1, vimentin, EMA (weakly), synaptophysin (partially), progesterone receptor (partially), and estrogen receptor (scatteredly). The patient has been followed up for 83 months after surgery by annual chest CT and no new lesions are detected in her left lung and other organs. The whole-exome sequencing identified 15 somatic mutations genes (MEGF6, DNAH5, AKT1, GPRIN2, PIK3AP1, FBXO40, HERC1, VPS16, MORN1, ZNF474, CTNNB1, ZNF251, TSC1, ATM, KDR). Pathway analysis showed possible pathways like the components of CTNNB1, AKT1, and TSC1 mutations in the PI3K/AKT signalings and AKT1, KDR and ATM in VEGF signaling pathway and AKT1 activation seemed closely related with these pathways. CONCLUSION: According to our and previous data, PSP with diffuse or multiple lesions is very rare, and the patients are most commonly seen in women in Asian countries. The misdiagnosis rate by clinical and intraoperative frozen-section assessment is high because of the multiple nodules in the lung and its confusing histological features. Long time follow up indicates surgical resection should not be considered as the preferred strategy for treating multiple PSP in the intralobar sites. AKT1 activation may contribute to the development of PSP while the pathogenesis of diffuse or multiple PSP still needs to be further analyzed.

23 Article Pulmonary sclerosing pneumocytoma remains a diagnostic challenge using frozen sections: a clinicopathological analysis of 59 cases. 2018

Yang, Cheng-Han / Lee, Li-Yu. ·Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. ·Histopathology · Pubmed #28881050.

ABSTRACT: AIMS: Using intraoperative frozen sections to diagnose pulmonary sclerosing pneumocytoma is always challenging. However, an accurate diagnosis is needed to guide surgical management and prevent unnecessary treatment. The aim of this study was to investigate the most frequently misdiagnosed histological patterns and evaluate the potential diagnostic pitfalls of using frozen sections. METHODS AND RESULTS: We reviewed retrospectively 59 cases of sclerosing pneumocytoma that underwent an intraoperative frozen section examination. All original frozen section slides and permanent section slides were reviewed. The rate of accurate diagnosis using frozen sections was 44.1%, the deferral rate was 15.3% and 10 cases (16.9%) were misdiagnosed as malignancy. A solid-predominant pattern is misdiagnosed more frequently than other growth patterns. We also summarised the five major diagnostic pitfalls, including hypercellularity, glandular spaces, desmoplasia-like sclerosis, cellular atypia and coagulative necrosis. CONCLUSIONS: In addition to evaluating the tumour circumscription and identifying the various growth patterns, we propose that the key to avoiding a misdiagnosis is to recognise the dual-cell populations in a tumour, i.e. cuboidal surface cells and stromal round cells.

24 Article Bilateral Pulmonary Pneumocytomas. 2017

Santamaria-Barria, Juan A / Sceusi, Eric L / Antonoff, Mara B. ·Department of Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas. Electronic address: Juan.A.Santamaria@uth.tmc.edu. · Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. ·Semin Thorac Cardiovasc Surg · Pubmed #29698656.

ABSTRACT: -- No abstract --

25 Article Pulmonary sclerosing pneumocytoma with mediastinal lymph node metastasis. 2017

Soo, Ing Xiang / Sittampalam, Kesavan / Lim, Chong Hee. ·1 Department of Cardiothoracic Surgery, 68753 National Heart Centre Singapore , Singapore. · 2 Department of Pathology, 68753 Singapore General Hospital , Singapore. ·Asian Cardiovasc Thorac Ann · Pubmed #28825313.

ABSTRACT: Pulmonary sclerosing pneumocytoma is a rare tumour with 23 cases reported to have metastasis to lymph nodes, but to date, only 6 had involved mediastinal nodal stations. Our patient was a 40-year-old Asian female with a 2.5 cm nodule in her right lower lobe. Positron-emission tomography suggested no nodal disease; but after resection, the intra-lobular, hilar and subcarinal nodes were all found to be involved. As prognosis of this rare disease is uncertain, we aim to report our findings against available literature and similar cases.

Next