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Sleep Apnea Syndromes: HELP
Articles by Daniel Champeau
Based on 2 articles published since 2008
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Between 2008 and 2019, Dan Champeau wrote the following 2 articles about Sleep Apnea Syndromes.
 
+ Citations + Abstracts
1 Review Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. 2014

Nadeem, Rashid / Singh, Mukesh / Nida, Mahwish / Waheed, Irfan / Khan, Adnan / Ahmed, Saeed / Naseem, Jawed / Champeau, Daniel. ·Rosalind Franklin University of Medicine and Science,Chicago Medical School, North Chicago,IL. · Department of Cardiology, James A Lovell Federal Health Care Center, North Chicago, IL. · Rematul lil Alameen Institute of Cardiology, Lahore, Pakistan. · New York University, New York,NY. · University of Karachi, Karachi, Pakistan. ·J Clin Sleep Med · Pubmed #24910548.

ABSTRACT: BACKGROUND: Obstructive sleep apnea (OSA) is associated with obesity, metabolic syndrome, and dyslipidemia, which may be related to decrease androgen levels found in OSA patients. Dyslipidemia may contribute to atherosclerosis leading to increasing risk of heart disease. METHODS: Systematic review was conducted using PubMed and Cochrane library by utilizing different combinations of key words; sleep apnea, obstructive sleep apnea, serum lipids, dyslipidemia, cholesterol, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG). Inclusion criteria were: English articles, and studies with adult population in 2 groups of patients (patients with OSA and without OSA). A total 96 studies were reviewed for inclusion, with 25 studies pooled for analysis. RESULTS: Sixty-four studies were pooled for analysis; since some studies have more than one dataset, there were 107 datasets with 18,116 patients pooled for meta-analysis. All studies measured serum lipids. Total cholesterol pooled standardized difference in means was 0.267 (p = 0.001). LDL cholesterol pooled standardized difference in means was 0.296 (p = 0.001). HDL cholesterol pooled standardized difference in means was -0.433 (p = 0.001). Triglyceride pooled standardized difference in means was 0.603 (p = 0.001). Meta-regression for age, BMI, and AHI showed that age has significant effect for TC, LDL, and HDL. BMI had significant effect for LDL and HDL, while AHI had significant effect for LDL and TG. CONCLUSION: Patients with OSA appear to have increased dyslipidemia (high total cholesterol, LDL, TG, and low HDL).

2 Article Effect of CPAP treatment for obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. 2014

Nadeem, Rashid / Singh, Mukesh / Nida, Mahwish / Kwon, Sarah / Sajid, Hassan / Witkowski, Julie / Pahomov, Elizabeth / Shah, Kruti / Park, William / Champeau, Dan. ·Rosalind Franklin University of Medicine and Science, North Chicago, IL. · Rematul lil Alameen Institute of Cardiology, Lahore, Pakistan. · McMaster University, Hamilton, Canada. ·J Clin Sleep Med · Pubmed #25325596.

ABSTRACT: STUDY OBJECTIVE: Patients with obstructive sleep apnea (OSA) frequently exhibit higher rates of dyslipidemia, a risk factor for cardiovascular and cerebrovascular disorders. Treatment for OSA by CPAP may improve cholesterol metabolism. This meta-regression analysis (MA) estimates the effect of CPAP treatment on dyslipidemia. METHODS: PubMed and Cochrane libraries were searched by utilizing different combinations of keywords: CPAP, obstructive sleep apnea, serum lipids, dyslipidemia, cholesterol, total cholesterol (TC), low density lipoprotein, LDL, high density lipoprotein, HDL, triglyceride, and TG. Inclusion criteria were: (1) English articles and (2) studies with an adult population with the diagnosis of OSA who were treated with CPAP. The OSA group must have cholesterol profile including TC, LDLc, HDLc, and TG, without and with CPAP treatment. Fifty-four studies were reviewed, while 29 studies pooled for MA. RESULTS: Thirty-four datasets from 29 studies with 1,958 subjects pooled. Treatment duration range was from 2 days to 1 year. TC standardized mean differences (SMD) ranged from -41.5 to -0.077, pooled mean difference (PMD) was -5.660 (LL -6.715 to UL -4.606, p < 0.001). SMD in LDL ranged from -3.7 to 0; PMD was -0.488 (LL -0.715 to UL -0.261, p < 0.001). HDL SMD ranged from -0.498 to 1.94. The PMD was 0.207 (LL 0.05 to UL 0.364, p < 0.01). TG SMD ranged from -9.327 to 1.98; PMD was -0.054 (LL -0.124 to UL 0.016, p < 0.129). CONCLUSIONS: CPAP treatment for OSA seems to improve dyslipidemia (decrease in total cholesterol and LDL, and increase in HDL). It does not appear to affect TG levels.