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Sleep Apnea Syndromes: HELP
Articles by Isabel Fernández-Navarro
Based on 7 articles published since 2010
(Why 7 articles?)
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Between 2010 and 2020, Isabel Fernandez-Navarro wrote the following 7 articles about Sleep Apnea Syndromes.
 
+ Citations + Abstracts
1 Review Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea. 2016

Martínez-Ceron, Elisabet / Fernández-Navarro, Isabel / Garcia-Rio, Francisco. ·Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. · Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain; Universidad Autónoma de Madrid, Madrid, Spain; CIBER de Enfermedades Respiratorias-CIBERES, Madrid, Spain. Electronic address: fgr01m@gmail.com. ·Sleep Med Rev · Pubmed #26146025.

ABSTRACT: A possible association between obstructive sleep apnea (OSA) and type 2 diabetes (T2DM) has been suggested. OSA could alter glucose metabolism, generating insulin resistance and favoring the development of T2DM. In addition, our greater understanding of intermediate disorders produced by intermittent hypoxia and sleep fragmentation, such as sympathetic activation, oxidative stress, systemic inflammation and alterations in appetite-regulating hormones, provides biological plausibility to this possible association. Nevertheless, there are still few data available about the consequences of suppressing apnea. Therefore, the objective of this review was to analyze current knowledge about the effect of continuous positive airway pressure (CPAP) on glucose metabolism. A global interpretation of the studies evaluated shows that CPAP could improve insulin resistance, and perhaps also glycemic control, in OSA patients who still have not developed diabetes. In addition, it seems possible that the effect of CPAP is still greater in patients with OSA and T2DM, particularly in those patients with more severe and symptomatic OSA, in those with poorer baseline glycemic control and with greater compliance and duration of CPAP treatment. In conclusion, although the current information available is limited, it suggests that apnea reversion by means of CPAP could improve the control of glucose metabolism.

2 Article Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression. 2018

Cubillos-Zapata, Carolina / Hernández-Jiménez, Enrique / Avendaño-Ortiz, José / Toledano, Victor / Varela-Serrano, Anibal / Fernández-Navarro, Isabel / Casitas, Raquel / Carpio, Carlos / Aguirre, Luis A / García-Río, Francisco / López-Collazo, Eduardo. ·The Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, Spain. · Center for Biomedical Research Network of Respiratory Diseases (CIBERES), Madrid, Spain. · Respiratory Diseases Group, IdiPAZ and Respiratory Service of La Paz University Hospital, Madrid, Spain. ·Mediators Inflamm · Pubmed #29997451.

ABSTRACT: Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIF1

3 Article The effect of treatment for sleep apnoea on determinants of blood pressure control. 2017

Casitas, Raquel / Martínez-Cerón, Elisabet / Galera, Raúl / Cubillos-Zapata, Carolina / González-Villalba, María Jesús / Fernández-Navarro, Isabel / Sánchez, Begoña / García-Sánchez, Aldara / Zamarrón, Ester / García-Río, Francisco. ·Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. · Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. · Servicio de Análisis Clínicos, Hospital Universitario La Paz, Madrid, Spain. · Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain fgr01m@gmail.com. · Departmento de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. ·Eur Respir J · Pubmed #29146604.

ABSTRACT: Our aim was to assess the effect of continuous positive airway pressure (CPAP) on the nocturnal evolution of peripheral chemosensitivity, renin-angiotensin-aldosterone system activity, sympathetic tone and endothelial biomarkers in obstructive sleep apnoea (OSA) patients with isolated nocturnal hypertension (INH) or day-night sustained hypertension (D-NSH).In a crossover randomised trial, 32 OSA patients newly diagnosed with hypertension and without antihypertensive treatment were randomly assigned to 12 weeks of CPAP or sham CPAP. Peripheral chemosensitivity was evaluated before and after sleep using the hypoxic withdrawal test (%Δ

4 Article Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea. 2017

Cubillos-Zapata, Carolina / Avendaño-Ortiz, Jose / Hernandez-Jimenez, Enrique / Toledano, Victor / Casas-Martin, Jose / Varela-Serrano, Anibal / Torres, Marta / Almendros, Isaac / Casitas, Raquel / Fernández-Navarro, Isabel / Garcia-Sanchez, Aldara / Aguirre, Luis A / Farre, Ramón / López-Collazo, Eduardo / García-Rio, Francisco. ·Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Madrid, Spain. · Respiratory Diseases Group, Respiratory Service, La Paz University Hospital, IdiPAZ, Madrid, Spain. · The Innate Immune Response Group, La Paz University Hospital, IdiPAZ, Madrid, Spain. · Sleep Laboratory, Pneumology Service, Hospital Clinic, University of Barcelona, Barcelona, Spain. · Biophysics and Bioengineering Unit, Faculty of Medicine, University of Barcelona-IDIBAPS, Barcelona, Spain. · Joint principal investigators. · Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Madrid, Spain fgr01m@gmail.com. · Dept of Medicine, Autonomous University of Madrid, Madrid, Spain. ·Eur Respir J · Pubmed #29051270.

ABSTRACT: Obstructive sleep apnoea (OSA) is associated with higher cancer incidence, tumour aggressiveness and cancer mortality, as well as greater severity of infections, which have been attributed to an immune deregulation. We studied the expression of programmed cell death (PD)-1 receptor and its ligand (PD-L1) on immune cells from patients with OSA, and its consequences on immune-suppressing activity. We report that PD-L1 was overexpressed on monocytes and PD-1 was overexpressed on CD8

5 Article Monocytes inhibit NK activity 2017

Hernández-Jiménez, Enrique / Cubillos-Zapata, Carolina / Toledano, Victor / Pérez de Diego, Rebeca / Fernández-Navarro, Isabel / Casitas, Raquel / Carpio, Carlos / Casas-Martín, Jose / Valentín, Jaime / Varela-Serrano, Anibal / Avendaño-Ortiz, Jose / Alvarez, Enrique / Aguirre, Luis A / Pérez-Martínez, Antonio / De Miguel, Maria P / Belda-Iniesta, Cristobal / García-Río, Francisco / López-Collazo, Eduardo. ·The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain. · CIBER of Respiratory Diseases (CIBERES), Madrid, Spain. · These authors contributed equally to this work. · Respiratory Diseases Group, IdiPAZ and Respiratory Service of La Paz University Hospital, Madrid, Spain. · EMPIREO, Madrid, Spain. · Cell Engineering Laboratory, La Paz University Hospital Health Research Institute, IdiPAZ, Madrid, Spain. · Research Foundation HM Hospitals, Madrid, Spain. · The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain elopezc@salud.madrid.org. ·Eur Respir J · Pubmed #28619958.

ABSTRACT: Obstructive sleep apnoea (OSA) is associated with cancer incidence and mortality. The contribution of the immune system appears to be crucial; however, the potential role of monocytes and natural killer (NK) cells remains unclear.Quantitative reverse transcriptase PCR, flow cytometry and

6 Article Central Apneas and REM Sleep Behavior Disorder as an Initial Presentation of Multiple System Atrophy. 2016

Garcia-Sanchez, Aldara / Fernandez-Navarro, Isabel / Garcia-Rio, Francisco. ·Respiratory Medicine, La Paz Hospital, Autónoma University of Madrid, idiPAZ, CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain. ·J Clin Sleep Med · Pubmed #26518702.

ABSTRACT: ABSTRACT: We present the case of a patient with multiple system atrophy who presented with central apnea as the only sleep disordered breathing, associated with REM behavior disorder and restless legs syndrome. This presentation of the disease is unusual and probably reflects more widespread involvement at the onset. With this case, we show the importance of considering this kind of disease in the differential diagnosis of central sleep apnea syndromes.

7 Article CPAP effect on recurrent episodes in patients with sleep apnea and myocardial infarction. 2013

Garcia-Rio, Francisco / Alonso-Fernández, Alberto / Armada, Eduardo / Mediano, Olga / Lores, Vanesa / Rojo, Blas / Fernández-Lahera, Juan / Fernández-Navarro, Isabel / Carpio, Carlos / Ramírez, Teresa. ·Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain; CIBER Enfermedades Respiratorias (CIBERES), Spain. Electronic address: fgr01m@gmail.com. ·Int J Cardiol · Pubmed #23302113.

ABSTRACT: BACKGROUND: Obstructive sleep apnea (OSA) is linked to increased cardiovascular risk, but the association between OSA and myocardial infarction (MI) remains controversial. Our objectives were to compare the frequency of OSA in patients with acute MI and in a population-based sample of control subjects, and to evaluate the impact of CPAP on recurrent MI and coronary revascularization. METHODS: Case-control study with a 6-year follow-up of the case cohort. 192 acute MI patients and 96 matched control subjects without coronary artery disease (CAD) (ratio 2:1). After overnight polysomnography, CPAP was recommended if apnea-hypopnea index (AHI) ≥ 5, and a mean daily use >3.5h/day was considered necessary to maintain the treatment. Lipids, fasting glucose, blood pressure, spirometry, comorbidity and current treatment were also registered. End-points were recurrent MI or need of revascularization. RESULTS: OSA was an independent predictor of MI, with odds ratio 4.9 (95% confidence interval [CI] 2.9-8.3, p=0.017). 63 MI patients without OSA, 52 untreated patients with OSA and 71 OSA patients treated with CPAP were included in the follow-up study. After adjustment for confounding factors, treated OSA patients had a lower risk of recurrent MI (adjusted hazard ratio 0.16 [95%CI 0.03-0.76, p=0.021]) and revascularization (adjusted hazard ratio 0.15 [95%CI 0.03-0.79, p=0.025]) than untreated OSA patients, and similar to non-OSA patients. CONCLUSION: Mild-severe OSA is an independent risk factor for MI. Risk of recurrent MI and revascularization was lower in OSA patients who tolerated CPAP.