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Sleep Apnea Syndromes: HELP
Articles by Christos A. Goudis
Based on 2 articles published since 2008
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Between 2008 and 2019, Christos A. Goudis wrote the following 2 articles about Sleep Apnea Syndromes.
 
+ Citations + Abstracts
1 Review Obstructive sleep and atrial fibrillation: Pathophysiological mechanisms and therapeutic implications. 2017

Goudis, Christos A / Ketikoglou, Dimitrios G. ·Cardiology Department, Serres General Hospital, Serres, Greece. Electronic address: cgoudis@hotmail.com. · Cardiology Department, European Interbalkan Medical Center, Thessaloniki, Greece. ·Int J Cardiol · Pubmed #28040290.

ABSTRACT: Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF. Several pathophysiological mechanisms, including apnea-induced hypoxia, intrathoracic pressure shifts, sympathovagal imbalance, atrial remodeling, oxidative stress, inflammation and neurohumoral activation have been implicated in the occurrence of AF in OSA patients. In addition, OSA has been shown to reduce success rates of antiarrhythmic drugs, electrical cardioversion and catheter ablation in AF. Effective prevention of obstructive respiratory events by continuous positive airway pressure ventilation (CPAP) reduces sympathovagal activation and recurrence of AF. The present review describes the relationship between OSA and AF, presents the pathophysiological mechanisms implicating OSA in AF occurrence, and provides an update of the potential therapeutic interventions for patients with OSA and AF.

2 Review Obesity and atrial fibrillation: A comprehensive review of the pathophysiological mechanisms and links. 2015

Goudis, Christos A / Korantzopoulos, Panagiotis / Ntalas, Ioannis V / Kallergis, Eleftherios M / Ketikoglou, Dimitrios G. ·Department of Cardiology, General Hospital of Grevena, Grevena, Greece. · First Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece. Electronic address: p.korantzopoulos@yahoo.gr. · First Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece. · Department of Cardiology, University Hospital of Heraklion, Heraklion, Greece. · Department of Cardiology, Interbalkan Medical Center, Thessaloniki, Greece. ·J Cardiol · Pubmed #25959929.

ABSTRACT: Obesity is a worldwide health problem with epidemic proportions that has been associated with atrial fibrillation (AF). Even though the underlying pathophysiological mechanisms have not been completely elucidated, several experimental and clinical studies implicate obesity in the initiation and perpetuation of AF. Of note, hypertension, diabetes mellitus, metabolic syndrome, coronary artery disease, and obstructive sleep apnea, represent clinical correlates between obesity and AF. In addition, ventricular adaptation, diastolic dysfunction, and epicardial adipose tissue appear to be implicated in atrial electrical and structural remodeling, thereby promoting the arrhythmia in obese subjects. The present article provides a concise overview of the association between obesity and AF, and highlights the underlying pathophysiological mechanisms.