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Sleep Apnea Syndromes: HELP
Articles by Diego Robles Mazzotti
Based on 8 articles published since 2009
(Why 8 articles?)
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Between 2009 and 2019, D. R. Mazzotti wrote the following 8 articles about Sleep Apnea Syndromes.
 
+ Citations + Abstracts
1 Review Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity. 2018

Mazzotti, Diego R / Lim, Diane C / Sutherland, Kate / Bittencourt, Lia / Mindel, Jesse W / Magalang, Ulysses / Pack, Allan I / de Chazal, Philip / Penzel, Thomas. ·Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, United States of America. ·Physiol Meas · Pubmed #30047487.

ABSTRACT: BACKGROUND: Obstructive sleep apnea (OSA) is a heterogeneous sleep disorder with many pathophysiological pathways to disease. Currently, the diagnosis and classification of OSA is based on the apnea-hypopnea index, which poorly correlates to underlying pathology and clinical consequences. A large number of in-laboratory sleep studies are performed around the world every year, already collecting an enormous amount of physiological data within an individual. Clinically, we have not yet fully taken advantage of this data, but combined with existing analytical approaches, we have the potential to transform the way OSA is managed within an individual patient. Currently, respiratory signals are used to count apneas and hypopneas, but patterns such as inspiratory flow signals can be used to predict optimal OSA treatment. Electrocardiographic data can reveal arrhythmias, but patterns such as heart rate variability can also be used to detect and classify OSA. Electroencephalography is used to score sleep stages and arousals, but specific patterns such as the odds-ratio product can be used to classify how OSA patients responds differently to arousals. OBJECTIVE: In this review, we examine these and many other existing computer-aided polysomnography signal processing algorithms and how they can reflect an individual's manifestation of OSA. SIGNIFICANCE: Together with current technological advance, it is only a matter of time before advanced automatic signal processing and analysis is widely applied to precision medicine of OSA in the clinical setting.

2 Review The role inflammatory response genes in obstructive sleep apnea syndrome: a review. 2016

de Lima, Francisco Fábio Ferreira / Mazzotti, Diego R / Tufik, Sergio / Bittencourt, Lia. ·Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925 Vila Clementino, São Paulo, SP, 04024-002, Brazil. · Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925 Vila Clementino, São Paulo, SP, 04024-002, Brazil. mazzottidr@gmail.com. ·Sleep Breath · Pubmed #26201496.

ABSTRACT: BACKGROUND: Obstructive sleep apnea syndrome (OSAS) has a negative impact on health and behavior of millions of individuals worldwide. The pathogenesis of this disorder is a multifactorial process related to a variety of mechanisms, including selective activation of inflammatory response pathways. A number of inflammatory factors, such as IL-6, IL-8, and TNF-α, can be found in high concentrations in subjects with OSAS and may serve as biological markers of this disease. The concentration of these cytokines contributes to weight gain in patients with OSAS and can also modify the risk of obesity-related metabolic disorders, especially insulin resistance. Nevertheless, the mechanisms by which specific genes are associated with these processes are still poorly known. In addition to gene expression studies, investigations aiming at the identification of epigenetic factors associated with OSAS are still scarce in the literature. The documented data support the hypothesis that the molecular changes that mediate inflammatory response are important mechanisms in the pathogenesis of OSAS, sleepiness, insulin resistance, visceral obesity, and cardiovascular disease, perhaps by leading to a more severe OSAS. Often, systemic changes may not be detected in mild OSA; however, molecular changes, which are much more sensitive to the mechanisms of intermittent hypoxia and oxidative stress, may be present. PURPOSE: This review aimed to show an updated view on the studies evaluating the genetic basis of inflammatory response in many aspects of OSAS and to highlight potential research areas not fully explored to date in this field.

3 Clinical Trial The effect of the severity of obstructive sleep apnea syndrome on telomere length. 2016

Tempaku, Priscila Farias / Mazzotti, Diego Robles / Hirotsu, Camila / Andersen, Monica Levy / Xavier, Gabriela / Maurya, Pawan Kumar / Rizzo, Lucas Bortolotto / Brietzke, Elisa / Belangero, Sintia Iole / Bittencourt, Lia / Tufik, Sergio. ·Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil. · Laboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil. · Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil. · Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India. · Department of Psychiatry, University of Tuebingen, Tuebingen, Germany. · Grupo de Pesquisa em Neurociência Comportamental e Molecular do Transtorno Bipolar, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil. ·Oncotarget · Pubmed #27690344.

ABSTRACT: Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction. All individuals were subjected to one full-night polysomnography. LTL was significantly shorter in OSAS patients compared to controls. The results showed negative correlations between LTL and the following variables: apnea-hypopnea index, respiratory disturbance index, desaturation index and wake after sleep onset. LTL was positively correlated with sleep efficiency, total sleep time, basal, minimum and maximum oxygen saturation. Lastly, it was observed that OSAS severity was associated with shorter LTL even after adjusting for sex, age, years of schooling, body mass index, diabetes, stroke and heart attack. In conclusion, our study indicates the presence of an association between LTL and OSAS and a significant impact of severity of OSAS in telomeres shortening.

4 Article Challenges in congenital central hypoventilation syndrome (Ondine's curse) on pregnancy: a case report. 2017

Souza, Renato Teixeira / Campanharo, Felipe Favorette / Araujo Júnior, Edward / Moreira, Gustavo Antonio / Mazzotti, Diego Robles / Mattar, Rosiane / Moron, Antonio Fernandes / Coelho, Fernando Morgadinho Santos. ·a Department of Obstetrics , Paulista School of Medicine - Federal University of São Paulo (EPM-UNIFESP) , São Paulo-SP , Brazil. · b Department of Psychobiology , Paulista School of Medicine-Federal University of São Paulo (EPM-UNIFESP) , São Paulo-SP , Brazil. · c Discipline of Neurology , Paulista School of Medicine-Federal University of São Paulo (EPM-UNIFESP) , São Paulo-SP , Brazil. ·J Obstet Gynaecol · Pubmed #27866447.

ABSTRACT: -- No abstract --

5 Article Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans. 2013

Perry, Juliana C / Guindalini, Camila / Bittencourt, Lia / Garbuio, Silverio / Mazzotti, Diego R / Tufik, Sergio. ·Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil. Electronic address: julianaciniperry@gmail.com. ·Respir Physiol Neurobiol · Pubmed #23994550.

ABSTRACT: In this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA). Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups. Severe OSA patients were assigned to participate in a continuous positive airway pressure (CPAP) protocol for 6 months. Blood was collected and the expression of 84 genes analyzed using the RT(2) Profiler™ PCR array. Mild-to-moderate OSA patients demonstrated down-regulation of 2 genes associated with induction of apoptosis, while a total of 13 genes were identified in severe OSA patients. After controlling for body mass index, PRPF40A and PLOD3 gene expressions were strongly and independently associated with AHI scores. This research protocol highlights a number of molecular targets that might help the development of novel therapeutic strategies.

6 Article Association between uric acid levels and obstructive sleep apnea syndrome in a large epidemiological sample. 2013

Hirotsu, Camila / Tufik, Sergio / Guindalini, Camila / Mazzotti, Diego R / Bittencourt, Lia R / Andersen, Monica L. ·Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. ·PLoS One · Pubmed #23826169.

ABSTRACT: INTRODUCTION: Recurrent hypoxia, which is associated with obstructive sleep apnea syndrome (OSAS), leads to an increase in the degradation of adenosine triphosphatase into xanthine, which in turn increases uric acid concentrations. OBJECTIVE: The current study aimed to determine whether an association exists between OSAS and uric acid levels in the peripheral blood from a representative population of Sao Paulo (Brazil). METHODS: A population-based survey adopting a probabilistic 3-stage cluster sample of Sao Paulo was used to represent the population according to gender, age, and socioeconomic class. A total of 1,042 volunteers underwent polysomnography recordings for OSAS diagnosis, blood pressure assessment, and biochemical blood analysis, and answered questionnaires. RESULTS: Uric acid levels were correlated with most important risk factors for OSAS, such as AHI, desaturation time and index, minimum oxyhemoglobin saturation (SpO2), blood pressure, cholesterol, BMI, triglycerides and arousal, and with OSAS itself. Also, uric acid was increased in OSAS volunteers even after controlling for all confounders. Hyperuricemic volunteers presented lower mean and minimum SpO2 and increased desaturation index. Importantly, minimum SpO2 was a significant predictor of uric acid levels, which in turn was considered an independent predictor for OSAS in the binary logistic model. However, a ROC curve analysis for establishing cut-off points for uric acid levels as a biomarker of OSAS revealed moderate sensitivity and specificity. CONCLUSION: A strong association was found between uric acid levels and OSAS in a representative sample of the population of Sao Paulo. Although they do not qualify for a biomarker alone, uric acid levels may be involved in OSAS severity and should be considered in sleep apnea management in the future.

7 Article The human leucocyte antigen DQB1*0602 allele is associated with electroencephelograph differences in individuals with obstructive sleep apnoea syndrome. 2013

Manzotte, Thais / Guindalini, Camila / Mazzotti, Diego R / Palombini, Luciana / de Souza, Altay L / Poyares, Dalva / Bittencourt, Lia R A / Tufik, Sergio. ·Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil. ·J Sleep Res · Pubmed #23136848.

ABSTRACT: Human leucocyte antigen (HLA) DQB1*0602 allele, a well-known genetic risk factor for narcolepsy, has been associated with sleep parameters in healthy subjects. We aimed to assess the association of this allele with daytime sleepiness and altered sleep electroencephalogram characteristics in the general population and in patients with obstructive sleep apnoea syndrome (OSAS). Eight hundred and ninety-four individuals from the Epidemiologic Study of Sleep were genotyped for the HLA DQB1*0602 allele. Full-night polysomnography was performed, and daytime sleepiness was analysed according to the Epworth Sleepiness Scale. HLA-DQB1*0602 allele-positive and -negative subjects in the general population, as well as in patients with OSAS, exhibited similar sleep parameters and levels of daytime sleepiness. However, spectral analysis showed that allele-positive individuals with OSAS exhibited higher theta power during sleep Stage 1 (P < 0.05) in occipital derivations, and lower delta power during sleep Stages 1 and 2 (P < 0.01) compared with individuals negative for the allele, even after correction for potential confounders as age, sex, body mass index and European ancestry. No significant differences in the electroencephalogram variables were found in individuals without OSAS. The data highlight the HLA-DQB1*0602 as a potential genetic factor influencing sleep physiology in individuals diagnosed with OSAS.

8 Article Apolipoprotein E polymorphisms and sleep quality in obstructive sleep apnea syndrome. 2011

Pellegrino, R / Mazzotti, D R / Guindalini, C / Santos-Silva, R / Bittencourt, L R A / Tufik, S. ·Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo-SP, Brazil. ·Clin Chim Acta · Pubmed #21864519.

ABSTRACT: BACKGROUND: The purpose of this study was to evaluate the influence of polymorphism on sleep parameters of Obstructive Sleep Apnea Syndrome (OSAS) patients. METHODS: Patients were genotyped after a full-night polysomnography using the large Epidemiologic Sleep Study of São Paulo population-based sample. RESULTS: Individuals who carry the APOE ε2 allele showed longer sleep latency, lower sleep efficiency and higher numbers of arousals/hour, when compared to ε3 allele homozygous and carriers of ε4 allele (p<0.05). These findings remained significant even after correction for potential confounders, such as sex, age and African genetic ancestry. CONCLUSION: The APOE polymorphisms may modulate the effects of intermittent hypoxia and sleep fragmentation in the sleep architecture of OSAS patients, and that the presence of the ε2 allele may serve as a biological marker for the identification of a subgroup of patients who are more likely to suffer with OSAS detrimental effects on sleep, impacting not only the daily functioning, but also their quality of life.