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Sleep Apnea Syndromes: HELP
Articles from Pakistan
Based on 8 articles published since 2008
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These are the 8 published articles about Sleep Apnea Syndromes that originated from Pakistan during 2008-2019.
 
+ Citations + Abstracts
1 Review Meta-Analysis of Continuous Positive Airway Pressure as a Therapy of Atrial Fibrillation in Obstructive Sleep Apnea. 2015

Qureshi, Waqas T / Nasir, Usama Bin / Alqalyoobi, Shehabaldin / O'Neal, Wesley T / Mawri, Sagar / Sabbagh, Salah / Soliman, Elsayed Z / Al-Mallah, Mouaz H. ·Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina. Electronic address: WQureshi@wakehealth.edu. · University of Health Sciences, Lahore, Pakistan. · Department of Internal Medicine, University of Missouri Kansas City, Kansas City, Missouri. · Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina. · Department of Internal Medicine, Henry Ford Hospital, Detroit, MI. · Section on Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina. · Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, North Carolina. · King Abdulaziz Cardiac Center, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia. ·Am J Cardiol · Pubmed #26482182.

ABSTRACT: Atrial fibrillation (AF) is a significant health care problem for patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) as a therapy for OSA is underused, and it is unknown if CPAP might reduce rates of AF. We systematically reviewed the published reports on CPAP use and risk of AF. MEDLINE, EMBASE, CINAHL, Web of Science, meeting abstracts, and Cochrane databases were searched from inception to June 2015. Studies needed to report the rates of AF in participants who were and were not on CPAP. Data were extracted by 2 authors. A total of 8 studies on OSA were identified (1 randomized controlled trial) with 698 CPAP users and 549 non-CPAP users. In a random effects model, patients treated with CPAP had a 42% decreased risk of AF (pooled risk ratio, 0.58; 95% confidence interval, 0.47 to 0.70; p <0.001). There was low heterogeneity in the results (I(2) = 30%). In metaregression analysis, benefits of CPAP were stronger for younger, obese, and male patients (p <0.05). An inverse relationship between CPAP therapy and AF recurrence was observed. Results suggest that more patients with AF also should be tested for OSA.

2 Review Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. 2014

Nadeem, Rashid / Singh, Mukesh / Nida, Mahwish / Waheed, Irfan / Khan, Adnan / Ahmed, Saeed / Naseem, Jawed / Champeau, Daniel. ·Rosalind Franklin University of Medicine and Science,Chicago Medical School, North Chicago,IL. · Department of Cardiology, James A Lovell Federal Health Care Center, North Chicago, IL. · Rematul lil Alameen Institute of Cardiology, Lahore, Pakistan. · New York University, New York,NY. · University of Karachi, Karachi, Pakistan. ·J Clin Sleep Med · Pubmed #24910548.

ABSTRACT: BACKGROUND: Obstructive sleep apnea (OSA) is associated with obesity, metabolic syndrome, and dyslipidemia, which may be related to decrease androgen levels found in OSA patients. Dyslipidemia may contribute to atherosclerosis leading to increasing risk of heart disease. METHODS: Systematic review was conducted using PubMed and Cochrane library by utilizing different combinations of key words; sleep apnea, obstructive sleep apnea, serum lipids, dyslipidemia, cholesterol, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG). Inclusion criteria were: English articles, and studies with adult population in 2 groups of patients (patients with OSA and without OSA). A total 96 studies were reviewed for inclusion, with 25 studies pooled for analysis. RESULTS: Sixty-four studies were pooled for analysis; since some studies have more than one dataset, there were 107 datasets with 18,116 patients pooled for meta-analysis. All studies measured serum lipids. Total cholesterol pooled standardized difference in means was 0.267 (p = 0.001). LDL cholesterol pooled standardized difference in means was 0.296 (p = 0.001). HDL cholesterol pooled standardized difference in means was -0.433 (p = 0.001). Triglyceride pooled standardized difference in means was 0.603 (p = 0.001). Meta-regression for age, BMI, and AHI showed that age has significant effect for TC, LDL, and HDL. BMI had significant effect for LDL and HDL, while AHI had significant effect for LDL and TG. CONCLUSION: Patients with OSA appear to have increased dyslipidemia (high total cholesterol, LDL, TG, and low HDL).

3 Article Management of Obstructive Sleep Apnea Syndrome Associated with Severe Micrognathia. 2018

Khan, Muhammad Nazir / Asim, Muhamamd Adil / Shah, Irfan. ·Department of Oral and Maxillofacial Surgery, Combined Military Hospital (CMH), Peshawar, Pakistan. · Department of Oral and Maxillofacial Surgery, Rawal Institute of Health Sciences, Islamabad, Pakistan. · Department of Oral and Maxillofacial Surgery, Army Medical College, Rawalpindi, Pakistan. ·J Coll Physicians Surg Pak · Pubmed #30173692.

ABSTRACT: Obstructive sleep apnea syndrome (OSAS), commonly associated with mandibular micrognathia, is a serious condition that can lead to various devastating cardiovascular and neurocognitive consequences. Patients of OSAS with micrognathia present with many functional and esthetic problems. Therefore, comprehensive management of these patients requires multiple surgeries and frequent follow-up. Several surgical and non-surgical treatment options have been proposed for the treatment of OSAS. Distraction osteogenesis (DO) in maxillofacial region, although a newer treatment modality, is being increasingly favoured by many surgeons because of its many advantages over other treatment methods. We present comprehensive management of a case of OSAS associated with post temporomandibular joint ankylosis severe micrognathia. Various surgical treatment methods including DO and conventional orthognathic surgical procedures were employed in management of this patient of obstructive sleep apnea. Both functional and esthetic complaints of the patient were addressed, and we achieved exceptional results at the end of treatment.

4 Article Risk assessment for obstructive sleep apnea and anxiety in a Pakistani population with coronary artery disease. 2015

Khan, Muhammad Shahzeb / Bawany, Faizan Imran / Khan, Asadullah / Hussain, Mehwish / Ali, Syed Shayan / Shah, Syed Raza / Lashari, Muhammad Nawaz. ·Dow University of Health Sciences, 109/2 Khayabane Amir Khusro Phase 6 DHA, Karachi, Pakistan, shahzebkhan@gmail.com. ·Sleep Breath · Pubmed #24925822.

ABSTRACT: PURPOSE: Previous studies in the western world have reported the possible association of obstructive sleep apnea (OSA) with anxiety and cardiovascular diseases. However, the data from developing countries such as Pakistan remains scarce in this regard. The main aim of this study was to investigate the prevalence of coronary artery disease (CAD) patients who are at high risk of OSA and to determine the association between the risk of OSA and levels of anxiety. METHODS: The sample population consisted of 400 participants including 200 patients, who had been previously diagnosed with CAD, and 200 healthy controls. The 200 CAD patients were approached for inclusion in the study on their follow-ups after their acute symptoms had subsided. The patients were interviewed after a mean time period of 13 weeks post event. All patients with lung disease or respiratory infection were excluded from the study. The risk of OSA was determined using Berlin questionnaire, while the levels of anxiety were measured by Beck anxiety inventory scale (BAI). RESULTS: More than half (n = 104) of the CAD patients were at high risk of OSA while majority (n = 168) of the healthy controls were at low risk. The high risk of OSA was significantly (P < 0.0001) more prevalent in CAD patients compared with controls. It was also observed that the patients who were at high risk of OSA, among both cases and controls, had significantly (P values <0.001) higher levels of anxiety. CONCLUSION: A significant proportion of CAD patients are at high risk of OSA in our region. Moreover, OSA is also associated with greater levels of anxiety in both healthy people and CAD patients.

5 Article Compliance with continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea among privately paying patients- a cross sectional study. 2014

Hussain, Syed Fayyaz / Irfan, Muhammad / Waheed, Zeeshan / Alam, Naveen / Mansoor, Saba / Islam, Muhammad. ·Department of Medicine, The Aga Khan University Hospital, PO Box 3500, Stadium Road, Karachi 74800, Pakistan. Muhammad.irfan@aku.edu. ·BMC Pulm Med · Pubmed #25433468.

ABSTRACT: BACKGROUND: To evaluate the compliance, benefits and side effects associated with continuous positive airway pressure (CPAP) therapy among Pakistani patients treated for obstructive sleep apnea (OSA) in private sector. METHODS: Patients diagnosed to have OSA based on overnight study who were recommended for CPAP therapy, between 1998 and 2003, were evaluated by telephonic survey and review of hospital notes. Compliance, benefits and side effects associated with CPAP therapy were assessed. RESULTS: Out of 135 patients who were prescribed CPAP therapy, 75 could be contacted. Sixty (80%) started using CPAP within one month of diagnosis and 46 (61%) continued to use it long-term (beyond one year). Compliance with CPAP therapy was associated with higher body mass index, higher Epworth sleepiness scale score, history of witnessed apnea, and reduction in daytime sleepiness with CPAP therapy. OSA severity as assessed by apnea-hypopnea index did not affect compliance with CPAP therapy. Use of anti-depressants and CPAP induced sleep disturbances were associated with poor compliance with CPAP therapy. CONCLUSIONS: Obesity, excessive daytime sleepiness, witnessed apnea and improvement of daytime symptoms following use of CPAP were predictors of improved compliance. Use of antidepressants and CPAP induced sleep disturbances were predictors of poor compliance.

6 Article Effect of CPAP treatment for obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. 2014

Nadeem, Rashid / Singh, Mukesh / Nida, Mahwish / Kwon, Sarah / Sajid, Hassan / Witkowski, Julie / Pahomov, Elizabeth / Shah, Kruti / Park, William / Champeau, Dan. ·Rosalind Franklin University of Medicine and Science, North Chicago, IL. · Rematul lil Alameen Institute of Cardiology, Lahore, Pakistan. · McMaster University, Hamilton, Canada. ·J Clin Sleep Med · Pubmed #25325596.

ABSTRACT: STUDY OBJECTIVE: Patients with obstructive sleep apnea (OSA) frequently exhibit higher rates of dyslipidemia, a risk factor for cardiovascular and cerebrovascular disorders. Treatment for OSA by CPAP may improve cholesterol metabolism. This meta-regression analysis (MA) estimates the effect of CPAP treatment on dyslipidemia. METHODS: PubMed and Cochrane libraries were searched by utilizing different combinations of keywords: CPAP, obstructive sleep apnea, serum lipids, dyslipidemia, cholesterol, total cholesterol (TC), low density lipoprotein, LDL, high density lipoprotein, HDL, triglyceride, and TG. Inclusion criteria were: (1) English articles and (2) studies with an adult population with the diagnosis of OSA who were treated with CPAP. The OSA group must have cholesterol profile including TC, LDLc, HDLc, and TG, without and with CPAP treatment. Fifty-four studies were reviewed, while 29 studies pooled for MA. RESULTS: Thirty-four datasets from 29 studies with 1,958 subjects pooled. Treatment duration range was from 2 days to 1 year. TC standardized mean differences (SMD) ranged from -41.5 to -0.077, pooled mean difference (PMD) was -5.660 (LL -6.715 to UL -4.606, p < 0.001). SMD in LDL ranged from -3.7 to 0; PMD was -0.488 (LL -0.715 to UL -0.261, p < 0.001). HDL SMD ranged from -0.498 to 1.94. The PMD was 0.207 (LL 0.05 to UL 0.364, p < 0.01). TG SMD ranged from -9.327 to 1.98; PMD was -0.054 (LL -0.124 to UL 0.016, p < 0.129). CONCLUSIONS: CPAP treatment for OSA seems to improve dyslipidemia (decrease in total cholesterol and LDL, and increase in HDL). It does not appear to affect TG levels.

7 Article Risk for sleep apnea syndrome in Pakistan: a cross-sectional survey utilizing the Berlin questionnaire. 2009

Taj, Fawad / Aly, Zarmeneh / Arif, Osman / Khealani, Bhojo / Ahmed, Mansoor. ·Medical College, Aga Khan University, Karachi, Pakistan. fawadtaj@gmail.com ·Sleep Breath · Pubmed #18807081.

ABSTRACT: PURPOSE: The purpose of this study was to assess the prevalence of individuals at high risk for developing obstructive sleep apnea in the Pakistani population using a validated questionnaire. MATERIALS AND METHODS: This is a cross-sectional survey using a pre-validated, interviewer-administered questionnaire conducted at the Aga Khan University Hospital. All healthy individuals above 18 years of age attending a seminar were included as participants after consent. RESULTS: The percentage of people in the high-risk group was calculated to be 12.4% out of a population of 137. Presence of snoring, hypertension, and body mass index >27.5 kg/m(2) was found to be more prevalent in high-risk individuals. CONCLUSIONS: A significant proportion of the population is at high risk for obstructive sleep apnea syndrome.

8 Article Identifying people at high risk for developing sleep apnea syndrome (SAS): a cross-sectional study in a Pakistani population. 2008

Taj, Fawad / Aly, Zarmeneh / Kassi, Mahwash / Ahmed, Mansoor. ·Neurology, Department of Medicine, Aga Khan University, Karachi-74800, Pakistan. fawadtaj@gmail.com ·BMC Neurol · Pubmed #19091126.

ABSTRACT: BACKGROUND: Obstructive Sleep Apnea (OSA) is associated with many cardiovascular and psychiatric diseases. Day-time sleepiness is a common consequence of sleep apnea and correlates with road-traffic accidents (RTA). Pakistan has a high prevalence of factors which predispose an individual to OSA and death from RTAs are a huge burden. However there is a dearth of prevalence studies in this regard. We aim to understand local relevance of the disease and estimate the prevalence of individuals high-risk for OSA. METHODS: This cross-sectional survey was conducted among 450 individuals at Aga Khan University Hospital (AKUH), which is a tertiary care teaching hospital in Pakistan. We used the BQ as our measurement tool. Based on the responses, participants were grouped into high or low-risk for OSA. RESULTS: Our study sample size was 418 with 63.2% males. Mean age of our study population was 30.4 SD+/-12.3 years; and mean BMI was 23.2 SD+/-5 kg/m2. Out of the total sample size 24.9% reported snoring and there were twice as many males who snored as compared to females. Forty-five individuals reported that they had nodded off to sleep while driving at least once in their lifetime. On the other hand, the highest proportion of high risk individuals 47.6% was found in the age group 60 or above. The overall prevalence of individuals who were high risk for sleep apnea was 10%. CONCLUSION: A significant proportion of the population is at high-risk for OSA. Our study shows that despite low BMI and favorable craniofacial anatomy sleep apnea is still a locally relevant disease. Given the local relevance of OSAS, it is important to increase awareness among general population but more importantly among physicians of the developing countries, like Pakistan, about common clinical features and pertinent risk factors and complications of OSAS.