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Spinal Diseases: HELP
Articles by Armando Malcata
Based on 6 articles published since 2008
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Between 2008 and 2019, A. Malcata wrote the following 6 articles about Spinal Diseases.
 
+ Citations + Abstracts
1 Guideline Portuguese recommendations for the use of biological therapies in patients with axial spondyloarthritis - 2016 update. 2017

Machado, Pedro / Cerqueira, Marcos / Ávila-Ribeiro, Pedro / Aguiar, Renata / Bernardo, Alexandra / Sepriano, Alexandre / Águeda, Ana / Cordeiro, Ana / Raposo, Ana / Rodrigues, Ana M / Barcelos, Anabela / Malcata, Armando / Lopes, Carina / Vaz, Cláudia C / Nour, Dolores / Godinho, Fátima / Alvarenga, Fernando / Pimentel-Santos, Fernando / Canhão, Helena / Santos, Helena / Cunha, Inês / Neves, Joana Sousa / Fonseca, João Eurico / Gomes, João Lagoas / Tavares-Costa, José / Costa, Lúcia / Cunha-Miranda, Luís / Maurício, Luís / Cruz, Margarida / Afonso, Maria Carmo / Santos, Maria José / Bernardes, Miguel / Valente, Paula / Figueira, Ricardo / Pimenta, Sofia / Ramiro, Sofia / Pedrosa, Teresa / Costa, Tiago Afonso / Vieira-Sousa, Elsa. ·University College London, London, UK. · Rheumatology Department, Unidade Local de Saúde do Alto Minho, Hospital Conde de Bertiandos, Ponte de Lima, Portugal. · Rheumatology and Metabolic Bone Diseases Department, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal. · Rheumatology Department, Centro Hospitalar do Baixo Vouga, Hospital de Aveiro, Aveiro, Portugal. · Rheumatology Department, Centro Hospitalar de S. João, Porto, Portugal. · NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal. · Rheumatology Department, Hospital Garcia de Orta, Almada, Portugal. · Rheumatology Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal. · CEDOC, EpiDoC Unit, NOVA Medical School and National School of Public Health, Universidade Nova de Lisboa, Lisboa, Portugal. · Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. · CEDOC, EpiDoC Unit, NOVA Medical School and National School of Public Health, Universidade Nova de Lisboa; Rheumatology Department, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisboa, Portugal. · Rheumatology Department, Unidade Local de Saúde da Guarda, Guarda, Portugal. · Clínica Intregare Terapêutica - Fortaleza: Clínica da Família, Fortaleza, Brasil. · Consultório Privado de Reumatologia, Portugal. · Instituto Português de Reumatologia, Lisboa, Portugal. · Rheumatology and Metabolic Bone Diseases Department, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon Academic Medical Centre, Lisbon, P. · Rheumatology Department, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisboa, Portugal. · Centro Hospitalar de Entre o Douro e Vouga, Hospital de São Sebastião, Santa Maria da Feira, Portugal. · Centro Hospitalar do Funchal, Funchal, Madeira, Portugal. · NOVA Medical School, Universidade Nova de Lisboa; Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. ·Acta Reumatol Port · Pubmed #28894079.

ABSTRACT: OBJECTIVE: To update the recommendations for the treatment of axial spondyloarthritis (axSpA) with biological therapies, endorsed by the Portuguese Society of Rheumatology. METHODS: These treatment recommendations were formulated by Portuguese rheumatologists based on literature evidence and consensus opinion. At a national meeting, the 7 recommendations included in this document were discussed and updated. A draft of the full text of the recommendations was then circulated and suggestions were incorporated. A final version was again circulated before publication and the level of agreement among Portuguese Rheumatologists was anonymously assessed using an online survey. RESULTS: A consensus was achieved regarding the initiation, assessment of response and switching of biological therapies in patients with axSpA. In total, seven recommendations were produced. The first recommendation is a general statement indicating that biological therapy is not a first-line drug treatment option and should only be used after conventional treatment has failed. The second recommendation is also a general statement about the broad concept of axSpA adopted by these recommendations that includes both non-radiographic and radiographic axSpA. Recommendations 3 to 7 deal with the definition of active disease (including the recommended threshold of 2.1 for the Ankylosing Spondylitis Disease Activity Score [ASDAS] or the threshold of 4 [0-10 scale] for the Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]), conventional treatment failure (nonsteroidal anti-inflammatory drugs being the first-line drug treatment), assessment of response to treatment (based on an ASDAS improvement  of at least 1.1 units or a BASDAI improvement of at least 2 units [0-10 scale] or at least 50%), and strategy in the presence of an inadequate response (where switching is recommended) or in the presence of long-term remission (where a process of biological therapy optimization can be considered, either a gradual increase in the interval between doses or a decrease of each dose of the biological therapy). CONCLUSION: These recommendations may be used for guidance in deciding which patients with axSpA should be treated with biological therapies. They cover a rapidly evolving area of therapeutic intervention. As more evidence becomes available and more biological therapies are licensed, these recommendations will have to be updated.

2 Guideline Portuguese recommendations for the use of biological therapies in patients with axial spondyloarthritis--December 2011 update. 2012

Machado, Pedro / Bernardo, Alexandra / Cravo, Ana Rita / Rodrigues, Ana / Malcata, Armando / Nour, Dolores / Vieira-Sousa, Elsa / Godinho, Fátima / Pimentel, Fernando / Canhão, Helena / Santos, Helena / Cunha, Inês / Fonseca, João Eurico / Costa, José / Costa, Lúcia / Cunha-Miranda, Luís / Maurício, Luís / Cruz, Margarida / Santos, Maria José / Bernardes, Miguel / Bogas, Mónica / Valente, Paula / Ramiro, Sofia / Barcelos, Anabela / Anonymous1630731. ·Serviço de Reumatologia, Hospitais da Universidade de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal. pedrommcmachado@gmail.com ·Acta Reumatol Port · Pubmed #22781513.

ABSTRACT: OBJECTIVE: To develop recommendations for the treatment of axial spondyloarthritis with biological therapies, endorsed by the Portuguese Society of Rheumatology. METHODS: These treatment recommendations were formulated by Portuguese rheumatologists based on literature evidence and consensus opinion. A draft of the recommendations and supporting evidence was first circulated to all Portuguese rheumatologists and their suggestions were incorporated in the draft. Secondly, at a national meeting the recommendations were presented, discussed and revised. Finally, the document resulting from this meeting was again circulated to all Portuguese rheumatologists, who anonymously voted online on the level of agreement with the recommendations. RESULTS: A consensus was achieved regarding the initiation, assessment of response and switching biological therapies in patients with axial spondyloarthritis. CONCLUSION: These recommendations may be used for guidance in deciding which patients with axial spondyloarthritis should be treated with biological therapies. They cover a rapidly evolving area of therapeutic intervention. As more evidence becomes available and more biological therapies are licensed, these recommendations will have to be updated.

3 Review A case of infliximab-induced lupus in a patient with ankylosing spondylitis: is it safe switch to another anti-TNF-α agent? 2013

Santiago, Tânia / Santiago, Mariana Galante / Rovisco, João / Duarte, Cátia / Malcata, Armando / da Silva, José António Pereira. ·Clínica Universitária de Reumatologia (CURe), Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000-075, Coimbra, Portugal, tlousasantiago@hotmail.com. ·Clin Rheumatol · Pubmed #23955767.

ABSTRACT: Anti-TNF-α therapies are the latest class of medications found to be associated with drug-induced lupus, a distinctive entity known as anti-TNF-α-induced lupus (ATIL) (Williams et al., Rheumatology (Oxford) 48:716-20, 2009; De Rycke et al., Lupus 14:931-7, 2005; De Bandt et al., Clin Rheumatol 22:56-61, 2003). With the widespread use of these agents, it is likely that the incidence of ATIL will increase. The onset of ATIL in patients with rheumatoid arthritis and Crohn's disease has been described, but the literature regarding the occurrence of this entity in patients with ankylosing spondylitis (AS) is scarce (De Bandt et al., Clin Rheumatol 22:56-61, 2003; Ramos-Casals et al., Autoimmun Rev 9:188-93, 2010; Perez-Garcia et al., Rheumatology 45:114-116, 2006). To our knowledge, few reports of switching anti-TNF-α therapy after ATIL in AS have been reported (Akgül et al., Rheumatol Int, 2012). Therefore, it is not clear whether the development of ATIL should prohibit switch to another therapy, since patients may respond to another anti-TNF-α agent (Akgül et al., Rheumatol Int, 2012; Bodur et al., Rheumatol Int 29:451-454, 2009; Mounach et al., Clin Exp Rheumatol 26:1116-8, 2008; Williams and Cohen, Int J Dermatol 50:619-625, 2011; Ye et al., J Rheumatol 38:1216, 2011; Wetter and Davis, Mayo Clin Proc 84:979-984, 2009; Cush, Clin Exp Rheumatol 22:S141-147, 2004; Kocharla and Mongey, Lupus 18:169-7, 2009). A lack of published experience of successful anti-TNF-α switching is a cause of concern for rheumatologists faced with this challenging clinical scenario. We report the case of a 69-year-old woman with AS who developed infliximab-induced lupus, which did not recur despite the subsequent institution of etanercept. The authors review and discuss ATIL and the possible implications for subsequent treatment with alternative anti-TNF-α agents.

4 Article [Tracheal stenosis by extrinsic compression: a case of anterior cervical hypertrophic osteophytosis]. 2010

Coutinho, Margarida / Freitas, S / Malcata, A. ·Internato Complementar de Reumatologia, Serviço de Reumatologia, Hospitais da Universidade de Coimbra, Coimbra. margarida.coutinho@portugalmail.pt ·Acta Reumatol Port · Pubmed #20975645.

ABSTRACT: Anterior Cervical Hypertrophic Osteophytosis (ACHO) is a clinical entity caused by degenerative changes of the cervical spine. ACHO may also be found in Diffuse Idiopathic Skeletal Hyperostosis (DISH)1-3, Ankylosing Spondylitis and Post-traumatic Osteophytogenesis. In a minority of cases it may lead to oesophagical manifestations and less commonly, to respiratory complaints. The authors report the case of a 75-year-old male with a personal history of chronic tophaceous gout and chronic obstructive lung disease. The patient presented with a history of progressive worsening of dyspnoea and dysphagia (for solid food) as well as foreign body sensation at the cervical level. On general examination, the patient presented with slightly diminished breath sounds and an increased expiratory time. On rheumatologic examination, the patient had moderate limitation of all cervical movements, crepitating knees and multiple gout tophi in both hands. Cervical plain radiographs showed large anterior osteophytes at the level of C4 and C5. Flexible videobronchoscopy was also performed, showing an angle of distortion in the upper third of the tracheal wall, caused by extrinsic compression. These changes were confirmed by cervical CT scan which also documented an anterior sliding of the oesophagus due to large anterior cervical osteophytes. Videofluoroscopic swallow study revealed the presence of paradoxal contraction of the cricopharyngeal muscle. The patient was treated with a non-steroidal anti-inflammatory drug (NSAID) and a skeletal muscle relaxant. Dysphagia improved but not the respiratory symptoms. Although there was indication for surgical removal of the hypertrophic osteophytes, the patient refused surgery and continues to be followed-up regularly at our outpatient clinic.

5 Article [Sacral schwannoma in a lumbar spinal stenosis: a rare condition]. 2009

Monteiro, Paulo / Garcia, Jorge / Salvador, Maria João / Malcata, Armando. ·Serviço de Reumatologia dos Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000 Coimbra. pjr_monteiro@hotmail.com ·Acta Reumatol Port · Pubmed #19727058.

ABSTRACT: -- No abstract --

6 Article [Sternoclavicular joint in psoriatic arthritis]. 2009

Ambrósio, C / Alexandre, M / Malcata, A. ·Serviço de Reumatologia dos Hospitais da Universidade de Coimbra. catambrosio1@netcabo.pt ·Acta Reumatol Port · Pubmed #19377405.

ABSTRACT: -- No abstract --