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Thyroid Diseases HELP
Based on 30,726 articles since 2008
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These are the 30726 published articles about Thyroid Diseases that originated from Worldwide during 2008-2017.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Guideline Diagnostics and treatment of differentiated thyroid carcinoma in children - Guidelines of Polish National Societies. 2016

Niedziela, Marek / Handkiewicz-Junak, Daria / Małecka-Tendera, Ewa / Czarniecka, Agnieszka / Dedecjus, Marek / Lange, Dariusz / Kucharska, Anna / Gawlik, Aneta / Pomorski, Lech / Włoch, Jan / Bagłaj, Maciej / Słowińska-Klencka, Dorota / Sporny, Stanisław / Kurzawa, Paweł / Kropińska, Aleksandra / Krajewska, Jolanta / Czepczyński, Rafał / Ruchała, Marek / Lewiński, Andrzej / Jarząb, Barbara. ·Department of Paediatric Endocrinology and Rheumatology, Poznan University of Medical Sciences, Poznan, Poland. mniedzie@ump.edu.pl. · ·Endokrynol Pol · Pubmed #28042655.

ABSTRACT: -- No abstract --

2 Guideline Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines. 2016

Mitchell, A L / Gandhi, A / Scott-Coombes, D / Perros, P. ·The Newcastle upon Tyne Hospitals NHS Foundation Trust,Newcastle upon Tyne,UK. · Department of Breast and Endocrine Surgery,University Hospital of South Manchester,Manchester,UK. · University Hospital of Wales,Cardiff,UK. ·J Laryngol Otol · Pubmed #27841128.

ABSTRACT: This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides recommendations on the management of thyroid cancer in adults and is based on the 2014 British Thyroid Association guidelines. Recommendations • Ultrasound scanning (USS) of the nodule or goitre is a crucial investigation in guiding the need for fine needle aspiration cytology (FNAC). (R) • FNAC should be considered for all nodules with suspicious ultrasound features (U3-U5). If a nodule is smaller than 10 mm in diameter, USS guided FNAC is not recommended unless clinically suspicious lymph nodes on USS are also present. (R) • Cytological analysis and categorisation should be reported according to the current British Thyroid Association Guidance. (R) • Ultrasound scanning assessment of cervical nodes should be done in FNAC-proven cancer. (R) • Magnetic resonance imaging (MRI) or computed tomography (CT) should be done in suspected cases of retrosternal extension, fixed tumours (local invasion with or without vocal cord paralysis) or when haemoptysis is reported. When CT with contrast is used pre-operatively, there should be a two-month delay between the use of iodinated contrast media and subsequent radioactive iodine (I131) therapy. (R) • Fluoro-deoxy-glucose positron emission tomography imaging is not recommended for routine evaluation. (G) • In patients with thyroid cancer, assessment of extrathyroidal extension and lymph node disease in the central and lateral neck compartments should be undertaken pre-operatively by USS and cross-sectional imaging (CT or MRI) if indicated. (R) • For patients with Thy 3f or Thy 4 FNAC a diagnostic hemithyroidectomy is recommended. (R) • Total thyroidectomy is recommended for patients with tumours greater than 4 cm in diameter or tumours of any size in association with any of the following characteristics: multifocal disease, bilateral disease, extrathyroidal spread (pT3 and pT4a), familial disease and those with clinically or radiologically involved nodes and/or distant metastases. (R) • Subtotal thyroidectomy should not be used in the management of thyroid cancer. (G) • Central compartment neck dissection is not routinely recommended for patients with papillary thyroid cancer without clinical or radiological evidence of lymph node involvement, provided they meet all of the following criteria: classical type papillary thyroid cancer, patient less than 45 years old, unifocal tumour, less than 4 cm, no extrathyroidal extension on ultrasound. (R) • Patients with metastases in the lateral compartment should undergo therapeutic lateral and central compartment neck dissection. (R) • Patients with follicular cancer with greater than 4 cm tumours should be treated with total thyroidectomy. (R) • I131 ablation should be carried out only in centres with appropriate facilities. (R) • Serum thyroglobulin (Tg) should be checked in all post-operative patients with differentiated thyroid cancer (DTC), but not sooner than six weeks after surgery. (R) • Patients who have undergone total or near total thyroidectomy should be started on levothyroxine 2 µg per kg or liothyronine 20 mcg tds after surgery. (R) • The majority of patients with a tumour more than 1 cm in diameter, who have undergone total or near-total thyroidectomy, should have I131 ablation. (R) • A post-ablation scan should be performed 3-10 days after I131 ablation. (R) • Post-therapy dynamic risk stratification at 9-12 months is used to guide further management. (G) • Potentially resectable recurrent or persistent disease should be managed with surgery whenever possible. (R) • Distant metastases and sites not amenable to surgery which are iodine avid should be treated with I131 therapy. (R) • Long-term follow-up for patients with differentiated thyroid cancer (DTC) is recommended. (G) • Follow-up should be based on clinical examination, serum Tg and thyroid-stimulating hormone assessments. (R) • Patients with suspected medullary thyroid cancer (MTC) should be investigated with calcitonin and carcino-embryonic antigen levels (CEA), 24 hour catecholamine and nor metanephrine urine estimation (or plasma free nor metanephrine estimation), serum calcium and parathyroid hormone. (R) • Relevant imaging studies are advisable to guide the extent of surgery. (R) • RET (Proto-oncogene tyrosine-protein kinase receptor) proto-oncogene analysis should be performed after surgery. (R) • All patients with known or suspected MTC should have serum calcitonin and biochemical screening for phaeochromocytoma pre-operatively. (R) • All patients with proven MTC greater than 5 mm should undergo total thyroidectomy and central compartment neck dissection. (R) • Patients with MTC with lateral nodal involvement should undergo selective neck dissection (IIa-Vb). (R) • Patients with MTC with central node metastases should undergo ipsilateral prophylactic lateral node dissection. (R) • Prophylactic thyroidectomy should be offered to RET-positive family members. (R) • All patients with proven MTC should have genetic screening. (R) • Radiotherapy may be useful in controlling local symptoms in patients with inoperable disease. (R) • Chemotherapy with tyrosine kinase inhibitors may help in controlling local symptoms. (R) • For individuals with anaplastic thyroid carcinoma, initial assessment should focus on identifying the small proportion of patients with localised disease and good performance status, which may benefit from surgical resection and other adjuvant therapies. (G) • The surgical intent should be gross tumour resection and not merely an attempt at debulking. (G).

3 Guideline Pathological aspects of the assessment of head and neck cancers: United Kingdom National Multidisciplinary Guidelines. 2016

Helliwell, T R / Giles, T E. ·Department of Cellular Pathology,Liverpool Clinical Laboratories,University of Liverpool,UK. · Department of Cellular Pathology,Liverpool Clinical Laboratories,Liverpool,UK. ·J Laryngol Otol · Pubmed #27841114.

ABSTRACT: This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. It introduces the current best practice in histopathology and cytopathology as it pertains to head and neck and thyroid cancers. Recommendations • Accurate diagnosis of the type of malignancy is a key component of effective management. (R) • Surgeons and oncologists should understand the scope and limitations of cellular pathology in order to inform multidisciplinary discussions. (R) • A clinically suspected diagnosis of malignancy should be confirmed by biopsy or cytology before operation. (R) • Cytopathological diagnoses should be discussed with surgeons and radiologists to maximise the information gained from each modality of investigation. (R) • Pathological investigations are the basis for accurate cancer staging and stratification of clinical outcomes. (R).

4 Guideline Congenital hypothyroidism - Polish recommendations for therapy, treatment monitoring, and screening tests in special categories of neonates with increased risk of hypothyroidism. 2016

Kucharska, Anna Małgorzata / Beń-Skowronek, Iwona / Walczak, Mieczysław / Ołtarzewski, Mariusz / Szalecki, Mieczysław / Jackowska, Teresa / Lewiński, Andrzej / Bossowski, Artur. ·Department of Paediatrics and Endocrinology, Medical University of Warsaw, Poland. ankucharska@wum.edu.pl. · ·Endokrynol Pol · Pubmed #27828692.

ABSTRACT: Proper treatment of congenital hypothyroidism warrants normal intellectual and physical development. This paper introduces the principles of treatment of congenital hypothyroidism, the recommended levothyroxine dosage, and the aims of therapy with its justification. The principles of treatment, specialist care of the patient, and methods used to evaluate therapeutic effects are described. Based on these data, recommendations concerning treatment and its monitoring in patients with congenital hypothyroidism are formulated. The paper also highlights the importance of educating the patients and/or their caretakers as one of the basic components of an effective therapy. The interpretation of screening tests in preterm neonates is provided as well. In the current screening program in preterm children TSH was determined between days three and five of life and then after three weeks. During this time TSH values are frequently low because of the immaturity of the hypothalamic-pituitary axis. Due to the increased risk of primary and secondary hypothyroidism in preterm and low birth weight babies the determination of TSH and fT4 between days three and five of life is recommended, irrespective of the screening test. (Endokrynol Pol 2016; 67 (5): 536-547).

5 Guideline 2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition). 2016

Satoh, Tetsurou / Isozaki, Osamu / Suzuki, Atsushi / Wakino, Shu / Iburi, Tadao / Tsuboi, Kumiko / Kanamoto, Naotetsu / Otani, Hajime / Furukawa, Yasushi / Teramukai, Satoshi / Akamizu, Takashi. ·Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan. · ·Endocr J · Pubmed #27746415.

ABSTRACT: Thyroid storm is an endocrine emergency which is characterized by multiple organ failure due to severe thyrotoxicosis, often associated with triggering illnesses. Early suspicion, prompt diagnosis and intensive treatment will improve survival in thyroid storm patients. Because of its rarity and high mortality, prospective intervention studies for the treatment of thyroid storm are difficult to carry out. We, the Japan Thyroid Association and Japan Endocrine Society taskforce committee, previously developed new diagnostic criteria and conducted nationwide surveys for thyroid storm in Japan. Detailed analyses of clinical data from 356 patients revealed that the mortality in Japan was still high (∼11%) and that multiple organ failure and acute heart failure were common causes of death. In addition, multimodal treatment with antithyroid drugs, inorganic iodide, corticosteroids and beta-adrenergic antagonists has been suggested to improve mortality of these patients. Based on the evidence obtained by nationwide surveys and additional literature searches, we herein established clinical guidelines for the management of thyroid storm. The present guideline includes 15 recommendations for the treatment of thyrotoxicosis and organ failure in the central nervous system, cardiovascular system, and hepato-gastrointestinal tract, admission criteria for the intensive care unit, and prognostic evaluation. We also proposed preventive approaches to thyroid storm, roles of definitive therapy, and future prospective trial plans for the treatment of thyroid storm. We hope that this guideline will be useful for many physicians all over the world as well as in Japan in the management of thyroid storm and the improvement of its outcome.

6 Guideline AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ASSOCIAZIONE MEDICI ENDOCRINOLOGI MEDICAL GUIDELINES FOR CLINICAL PRACTICE FOR THE DIAGNOSIS AND MANAGEMENT OF THYROID NODULES--2016 UPDATE. 2016

Gharib, Hossein / Papini, Enrico / Garber, Jeffrey R / Duick, Daniel S / Harrell, R Mack / Hegedüs, Laszlo / Paschke, Ralf / Valcavi, Roberto / Vitti, Paolo / Anonymous2050868. · ·Endocr Pract · Pubmed #27167915.

ABSTRACT: Thyroid nodules are detected in up to 50 to 60% of healthy subjects. Most nodules do not cause clinically significant symptoms, and as a result, the main challenge in their management is to rule out malignancy, with ultrasonography (US) and fine-needle aspiration (FNA) biopsy serving as diagnostic cornerstones. The key issues discussed in these guidelines are as follows: (1) US-based categorization of the malignancy risk and indications for US-guided FNA (henceforth, FNA), (2) cytologic classification of FNA samples, (3) the roles of immunocytochemistry and molecular testing applied to thyroid FNA, (4) therapeutic options, and (5) follow-up strategy. Thyroid nodule management during pregnancy and in children are also addressed. On the basis of US features, thyroid nodules may be categorized into 3 groups: low-, intermediate-and high-malignancy risk. FNA should be considered for nodules ≤10 mm diameter only when suspicious US signs are present, while nodules ≤5 mm should be monitored rather than biopsied. A classification scheme of 5 categories (nondiagnostic, benign, indeterminate, suspicious for malignancy, or malignant) is recommended for the cytologic report. Indeterminate lesions are further subdivided into 2 subclasses to more accurately stratify the risk of malignancy. At present, no single cytochemical or genetic marker can definitely rule out malignancy in indeterminate nodules. Nevertheless, these tools should be considered together with clinical data, US signs, elastographic pattern, or results of other imaging techniques to improve the management of these lesions. Most thyroid nodules do not require any treatment, and levothyroxine (LT4) suppressive therapy is not recommended. Percutaneous ethanol injection (PEI) should be the first-line treatment option for relapsing, benign cystic lesions, while US-guided thermal ablation treatments may be considered for solid or mixed symptomatic benign thyroid nodules. Surgery remains the treatment of choice for malignant or suspicious nodules. The present document updates previous guidelines released in 2006 and 2010 by the American Association of Clinical Endocrinologists (AACE), American College of Endocrinology (ACE) and Associazione Medici Endocrinologi (AME).

7 Guideline American Cancer Society Head and Neck Cancer Survivorship Care Guideline. 2016

Cohen, Ezra E W / LaMonte, Samuel J / Erb, Nicole L / Beckman, Kerry L / Sadeghi, Nader / Hutcheson, Katherine A / Stubblefield, Michael D / Abbott, Dennis M / Fisher, Penelope S / Stein, Kevin D / Lyman, Gary H / Pratt-Chapman, Mandi L. ·Medical Oncologist, Moores Cancer Center, University of California at San Diego, La Jolla, CA. · Retired Head and Neck Surgeon, Former Associate Professor of Otolaryngology and Head and Neck Surgery, Louisiana State University Health and Science Center, New Orleans, LA. · Program Manager, National Cancer Survivorship Resource Center, American Cancer Society, Atlanta, GA. · Research Analyst-Survivorship, American Cancer Society, Atlanta, GA. · Professor of Surgery, Division of Otolaryngology-Head and Neck Cancer Surgery, and Director of Head and Neck Surgical Oncology, George Washington University, Washington, DC. · Associate Professor, Department of Head and Neck Surgery, Section of Speech Pathology and Audiology, The University of Texas MD Anderson Cancer Center, Houston, TX. · Medical Director for Cancer Rehabilitation, Kessler Institute for Rehabilitation, West Orange, NJ. · Chief Executive Officer, Dental Oncology Professionals, Garland, TX. · Clinical Instructor of Otolaryngology and Nurse, Miller School of Medicine, Department of Otolaryngology, Division of Head and Neck Surgery, University of Miami, Miami, FL. · Vice President, Behavioral Research, and Director, Behavioral Research Center, American Cancer Society, Atlanta, GA. · Co-Director, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, and Professor of Medicine, University of Washington School of Medicine, Seattle, WA. · Director, The George Washington University Cancer Institute, Washington, DC. ·CA Cancer J Clin · Pubmed #27002678.

ABSTRACT: Answer questions and earn CME/CNE The American Cancer Society Head and Neck Cancer Survivorship Care Guideline was developed to assist primary care clinicians and other health practitioners with the care of head and neck cancer survivors, including monitoring for recurrence, screening for second primary cancers, assessment and management of long-term and late effects, health promotion, and care coordination. A systematic review of the literature was conducted using PubMed through April 2015, and a multidisciplinary expert workgroup with expertise in primary care, dentistry, surgical oncology, medical oncology, radiation oncology, clinical psychology, speech-language pathology, physical medicine and rehabilitation, the patient perspective, and nursing was assembled. While the guideline is based on a systematic review of the current literature, most evidence is not sufficient to warrant a strong recommendation. Therefore, recommendations should be viewed as consensus-based management strategies for assisting patients with physical and psychosocial effects of head and neck cancer and its treatment. CA Cancer J Clin 2016;66:203-239. © 2016 American Cancer Society.

8 Guideline Diagnostics and Treatment of Thyroid Carcinoma. 2016

Jarząb, Barbara / Dedecjus, Marek / Handkiewicz-Junak, Daria / Lange, Dariusz / Lewiński, Andrzej / Nasierowska-Guttmejer, Anna / Ruchała, Marek / Słowińska-Klencka, Dorota / Nauman, Janusz / Adamczewski, Zbigniew / Bagłaj, Maciej / Bałdys-Waligórska, Agata / Barczyński, Marcin / Bednarczuk, Tomasz / Cichocki, Andrzej / Czarniecka, Agnieszka / Czepczyński, Rafał / Gawlik, Aneta / Hubalewska-Dydejczyk, Alicja / Jażdżewski, Krystian / Kamiński, Grzegorz / Karbownik-Lewińska, Małgorzata / Kos-Kudła, Beata / Kułakowski, Andrzej / Kuzdak, Krzysztof / Łącka, Katarzyna / Małecka-Tendera, Ewa / Niedziela, Marek / Pomorski, Lech / Sporny, Stanisław / Stojcev, Zoran / Syrenicz, Anhelli / Włoch, Jan / Krajewska, Jolanta / Szpak-Ulczok, Sylwia / Kalemba, Michal / Buziak-Bereza, Monika. ·Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice. bjarzab@io.gliwice.pl. · ·Endokrynol Pol · Pubmed #26884119.

ABSTRACT: Revised Guidelines of Polish National Societies Prepared on the initiative of the Polish Group for Endocrine Tumours approved in their final version between November 16th and 28th, 2015 by the Scientific Committee of the V Conference "Thyroid Cancer and other malignancies of endocrine glands" organised between November 14th and 17th, 2015 in Wisla, Poland; called by the following Societies: Polish Endocrine Society, Polish Society of Oncology, Polish Thyroid Association, Polish Society of Pathologists, Society of Polish Surgeons, Polish Society of Surgical Oncology, Polish Society of Clinical Oncology, Polish Society of Radiation Oncology, Polish Society of Nuclear Medicine, Polish Society of Paediatric Endocrinology, Polish Society of Paediatric Surgeons, Polish Society of Ultrasonography Gliwice-Wisła, 2015 DECLARATION: These recommendations are created by the group of delegates of the National Societies, which declare their willingness to participate in the preparation of the revised version of the Polish Guidelines. The members of the Working Group have been chosen from the specialists involved in medical care of patients with thyroid carcinoma. Directly before the preparation of the Polish national recommendations the American Thyroid Association (ATA) published its own guidelines together with a wide comment fulfilling evidence-based medicine (EBM) criteria. ATA Guidelines are consistent with National Comprehensive Cancer Network (NCCN) Recommendation. According to the members of the Working Group, it is necessary to adapt them to both the specific Polish epidemiological situation as well as to the rules referring to the Polish health system. Therefore, the Polish recommendations constitute a consensus of the experts' group, based on ATA information. The experts analysed previous Polish Guidelines, published in 2010, and other available data, and after discussion summed up the results in the form of these guidelines. It should be added that Part II, which constitutes a pathological part, has been available at the website of the Polish Society of Pathologists for acceptance of the members of the Society, and no essential comments have been proposed. The Members of the Group decided that a subgroup elected from among them would update the Guidelines, according to EBM rules, every year. The Revised Guidelines should help physicians to make reasonable choices in their daily practice; however, the final decision concerning an individual patient should be made by the caring physician responsible for treatment, or optimally by a therapeutic tumour board together with the patient, and should take into consideration the patient's health condition. It should be emphasised that the recommendations may not constitute a strict standard of clinical management imposed on medical staff. The data from clinical trials concerning numerous clinical situations are scarce. In such moments the opinion of the management may differ from the recommendations after considering possible benefits and disadvantages for the patient.

9 Guideline American Thyroid Association Statement on Remote-Access Thyroid Surgery. 2016

Berber, Eren / Bernet, Victor / Fahey, Thomas J / Kebebew, Electron / Shaha, Ashok / Stack, Brendan C / Stang, Michael / Steward, David L / Terris, David J / Anonymous1761069. ·1 Department of Endocrine Surgery, Cleveland Clinic , Cleveland, Ohio. · 2 Division of Endocrinology, Mayo Clinic , Jacksonville, Florida. · 3 Department of Endocrine Surgery, Weill Cornell Medical College/New York Presbyterian Hospital , New York, New York. · 4 Endocrine Oncology Branch, National Cancer Institutes of Health , Bethesda, Maryland. · 5 Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center , New York, New York. · 6 Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences , Little Rock, Arkansas. · 7 Division of Endocrine Surgery, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania. · 8 Department of Otolaryngology-Head and Neck Surgery, University Hospital , Cincinnati, Ohio. · 9 Department of Otolaryngology, Augusta University , Augusta, Georgia . · ·Thyroid · Pubmed #26858014.

ABSTRACT: BACKGROUND: Remote-access techniques have been described over the recent years as a method of removing the thyroid gland without an incision in the neck. However, there is confusion related to the number of techniques available and the ideal patient selection criteria for a given technique. The aims of this review were to develop a simple classification of these approaches, describe the optimal patient selection criteria, evaluate the outcomes objectively, and define the barriers to adoption. METHODS: A review of the literature was performed to identify the described techniques. A simple classification was developed. Technical details, outcomes, and the learning curve were described. Expert opinion consensus was formulated regarding recommendations for patient selection and performance of remote-access thyroid surgery. RESULTS: Remote-access thyroid procedures can be categorized into endoscopic or robotic breast, bilateral axillo-breast, axillary, and facelift approaches. The experience in the United States involves the latter two techniques. The limited data in the literature suggest long operative times, a steep learning curve, and higher costs with remote-access thyroid surgery compared with conventional thyroidectomy. Nevertheless, a consensus was reached that, in appropriate hands, it can be a viable option for patients with unilateral small nodules who wish to avoid a neck incision. CONCLUSIONS: Remote-access thyroidectomy has a role in a small group of patients who fit strict selection criteria. These approaches require an additional level of expertise, and therefore should be done by surgeons performing a high volume of thyroid and robotic surgery.

10 Guideline AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THYROID DYSFUNCTION CASE FINDING. 2016

Hennessey, James V / Garber, Jeffrey R / Woeber, Kenneth A / Cobin, Rhoda / Klein, Irwin / Anonymous70858 / Anonymous80858. · ·Endocr Pract · Pubmed #26848631.

ABSTRACT: Hypothyroidism and hyperthyroidism can be readily diagnosed and can be treated in a safe, cost-effective manner. Professional organizations have given guidance on how and when to employ thyroid-stimulating hormone testing for the detection of thyroid dysfunction. Most recently, the United States Preventive Services Task Force did not endorse screening for thyroid dysfunction based on a lack of proven benefit and potential harm of treating those with thyroid dysfunction, which is mostly subclinical disease. The American Association of Clinical Endocrinologists (AACE) is concerned that this may discourage physicians from testing for thyroid dysfunction when clinically appropriate. Given the lack of specificity of thyroid-associated symptoms, the appropriate diagnosis of thyroid disease requires biochemical confirmation. The Thyroid Scientific Committee of the AACE has produced this White Paper to highlight the important difference between screening and case-based testing in the practice of clinical medicine. We recommend that thyroid dysfunction should be frequently considered as a potential etiology for many of the nonspecific complaints that physicians face daily. The application and success of safe and effective interventions are dependent on an accurate diagnosis. We, therefore, advocate for an aggressive case-finding approach, based on identifying those persons most likely to have thyroid disease that will benefit from its treatment.

11 Guideline External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society. 2016

Kiess, Ana P / Agrawal, Nishant / Brierley, James D / Duvvuri, Umamaheswar / Ferris, Robert L / Genden, Eric / Wong, Richard J / Tuttle, R Michael / Lee, Nancy Y / Randolph, Gregory W. ·Department of Radiation Oncology, Johns Hopkins Medical Institute, Baltimore, Maryland. · Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medical Institute, Baltimore, Maryland. · Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. · Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.; VA Pittsburgh Health System, Pittsburgh, Pennsylvania. · Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania. · Department of Otolaryngology, Mount Sinai Hospital, New York, New York. · Department of Surgery - Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York. · Department of Medicine - Endocrinology Service, Memorial Sloan Kettering Cancer Center, New York, New York. · Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. · Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. ·Head Neck · Pubmed #26716601.

ABSTRACT: The use of external-beam radiotherapy (EBRT) in differentiated thyroid cancer (DTC) is debated because of a lack of prospective clinical data, but recent retrospective studies have reported benefits in selected patients. The Endocrine Surgery Committee of the American Head and Neck Society provides 4 recommendations regarding EBRT for locoregional control in DTC, based on review of literature and expert opinion of the authors. (1) EBRT is recommended for patients with gross residual or unresectable locoregional disease, except for patients <45 years old with limited gross disease that is radioactive iodine (RAI)-avid. (2) EBRT should not be routinely used as adjuvant therapy after complete resection of gross disease. (3) After complete resection, EBRT may be considered in select patients >45 years old with high likelihood of microscopic residual disease and low likelihood of responding to RAI. (4) Cervical lymph node involvement alone should not be an indication for adjuvant EBRT.

12 Guideline Consensus on management of advanced medullary thyroid carcinoma on behalf of the Working Group of Thyroid Cancer of the Spanish Society of Endocrinology (SEEN) and the Spanish Task Force Group for Orphan and Infrequent Tumors (GETHI). 2016

Grande, E / Santamaría Sandi, J / Capdevila, J / Navarro González, E / Zafón Llopis, C / Ramón Y Cajal Asensio, T / Gómez Sáez, J M / Jiménez-Fonseca, P / Riesco-Eizaguirre, G / Galofré, J C. ·Servicio de Oncología Médica, Hospital Ramón y Cajal, Carretera de Colmenar km 9,1, 28034, Madrid, Spain. egrande@oncologiahrc.com. · Endocrinology and Nutrition Service, Hospital Universitario de Cruces, Vizcaya, Spain. · Medical Oncology Service, Hospital Universitario Vall d'Hebron, Barcelona, Spain. · Endocrinology and Nutrition Service, Hospital Universitario Virgen del Rocio, Seville, Spain. · Endocrinology and Nutrition Service, Hospital Universitario Vall d'Hebron, Barcelona, Spain. · Medical Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. · CIBERDEM, Endocrinology and Nutrition Service, Hospital Universitario de Bellvitge, Barcelona, Spain. · Medical Oncology Service, Hospital Universitario Central de Asturias, Oviedo, Spain. · Endocrinology and Nutrition Service, Hospital Universitario de Móstoles, Madrid, Spain. · Endocrinology and Nutrition Service, Clínica Universidad de Navarra, Pamplona, Spain. ·Clin Transl Oncol · Pubmed #26687366.

ABSTRACT: BACKGROUND: Of all thyroid cancers, <5 % are medullary (MTC). It is a well-characterized neuroendocrine tumor arising from calcitonin-secreting C cells, and RET gene plays a central role on its pathogeny. METHODS: The electronic search was conducted using MEDLINE (PubMed), EMBASE and Cochrane Central Register of Controlled Trials. Quality assessments of selected current articles, guidelines and reviews of MTC were performed. RESULTS: This consensus updates and summarizes biology, treatment and prognostic considerations of MTC. CONCLUSIONS: Multidisciplinary teams and specialized centers are recommended for the management of MTC patients. In the metastatic setting, those patients with large volume of disease are candidates to start systemic treatment mainly if they are symptomatic and the tumor has progressed in the last 12-14 months. Wait and see strategy should be offered to patients with: disseminated disease with only high levels of calcitonin and no macroscopic structural disease, low burden and absence of progression.

13 Guideline 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. 2016

Haugen, Bryan R / Alexander, Erik K / Bible, Keith C / Doherty, Gerard M / Mandel, Susan J / Nikiforov, Yuri E / Pacini, Furio / Randolph, Gregory W / Sawka, Anna M / Schlumberger, Martin / Schuff, Kathryn G / Sherman, Steven I / Sosa, Julie Ann / Steward, David L / Tuttle, R Michael / Wartofsky, Leonard. ·1 University of Colorado School of Medicine , Aurora, Colorado. · 2 Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts. · 3 The Mayo Clinic , Rochester, Minnesota. · 4 Boston Medical Center , Boston, Massachusetts. · 5 Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania. · 6 University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania. · 7 The University of Siena , Siena, Italy . · 8 Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital , Harvard Medical School, Boston, Massachusetts. · 9 University Health Network, University of Toronto , Toronto, Ontario, Canada . · 10 Institute Gustave Roussy and University Paris Sud , Villejuif, France . · 11 Oregon Health and Science University , Portland, Oregon. · 12 University of Texas M.D. Anderson Cancer Center , Houston, Texas. · 13 Duke University School of Medicine , Durham, North Carolina. · 14 University of Cincinnati Medical Center , Cincinnati, Ohio. · 15 Memorial Sloan Kettering Cancer Center , New York, New York. · 16 MedStar Washington Hospital Center , Washington, DC. ·Thyroid · Pubmed #26462967.

ABSTRACT: BACKGROUND: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were revised in 2009, significant scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer. METHODS: The specific clinical questions addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of task force members. Task force panel members were educated on knowledge synthesis methods, including electronic database searching, review and selection of relevant citations, and critical appraisal of selected studies. Published English language articles on adults were eligible for inclusion. The American College of Physicians Guideline Grading System was used for critical appraisal of evidence and grading strength of recommendations for therapeutic interventions. We developed a similarly formatted system to appraise the quality of such studies and resultant recommendations. The guideline panel had complete editorial independence from the ATA. Competing interests of guideline task force members were regularly updated, managed, and communicated to the ATA and task force members. RESULTS: The revised guidelines for the management of thyroid nodules include recommendations regarding initial evaluation, clinical and ultrasound criteria for fine-needle aspiration biopsy, interpretation of fine-needle aspiration biopsy results, use of molecular markers, and management of benign thyroid nodules. Recommendations regarding the initial management of thyroid cancer include those relating to screening for thyroid cancer, staging and risk assessment, surgical management, radioiodine remnant ablation and therapy, and thyrotropin suppression therapy using levothyroxine. Recommendations related to long-term management of differentiated thyroid cancer include those related to surveillance for recurrent disease using imaging and serum thyroglobulin, thyroid hormone therapy, management of recurrent and metastatic disease, consideration for clinical trials and targeted therapy, as well as directions for future research. CONCLUSIONS: We have developed evidence-based recommendations to inform clinical decision-making in the management of thyroid nodules and differentiated thyroid cancer. They represent, in our opinion, contemporary optimal care for patients with these disorders.

14 Guideline Thyroid and parathyroid glands. 2015

Tamaki, Yasuhiro / Ikeda, Yoshifumi / Usui, Yoshiyuki / Okamura, Ritsuko / Kitamura, Kaoru / Kazuo, Shimizu / Tangoku, Akira. · ·Asian J Endosc Surg · Pubmed #26708581.

ABSTRACT: -- No abstract --

15 Guideline Anaplastic Thyroid Carcinoma, Version 2.2015. 2015

Haddad, Robert I / Lydiatt, William M / Ball, Douglas W / Busaidy, Naifa Lamki / Byrd, David / Callender, Glenda / Dickson, Paxton / Duh, Quan-Yang / Ehya, Hormoz / Haymart, Megan / Hoh, Carl / Hunt, Jason P / Iagaru, Andrei / Kandeel, Fouad / Kopp, Peter / Lamonica, Dominick M / McCaffrey, Judith C / Moley, Jeffrey F / Parks, Lee / Raeburn, Christopher D / Ridge, John A / Ringel, Matthew D / Scheri, Randall P / Shah, Jatin P / Smallridge, Robert C / Sturgeon, Cord / Wang, Thomas N / Wirth, Lori J / Hoffmann, Karin G / Hughes, Miranda. · ·J Natl Compr Canc Netw · Pubmed #26358798.

ABSTRACT: This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Thyroid Carcinoma focuses on anaplastic carcinoma because substantial changes were made to the systemic therapy recommendations for the 2015 update. Dosages and frequency of administration are now provided, docetaxel/doxorubicin regimens were added, and single-agent cisplatin was deleted because it is not recommended for patients with advanced or metastatic anaplastic thyroid cancer.

16 Guideline Subclinical hypothyroidism in the infertile female population: a guideline. 2015

Anonymous6460838. ·ASRM@asrm.org ·Fertil Steril · Pubmed #26239023.

ABSTRACT: There is controversy regarding whether to treat subtle abnormalities of thyroid dysfunction in the infertile female patient. This guideline document reviews the risks and benefits of treating subclinical hypothyroidism in female patients with a history of infertility and miscarriage, as well as obstetrical and neonatal outcomes in this population.

17 Guideline Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. 2015

Francis, Gary L / Waguespack, Steven G / Bauer, Andrew J / Angelos, Peter / Benvenga, Salvatore / Cerutti, Janete M / Dinauer, Catherine A / Hamilton, Jill / Hay, Ian D / Luster, Markus / Parisi, Marguerite T / Rachmiel, Marianna / Thompson, Geoffrey B / Yamashita, Shunichi / Anonymous2000828. ·1 Division of Pediatric Endocrinology, Virginia Commonwealth University , Children's Hospital of Richmond, Richmond, Virginia. · 2 Department of Endocrine Neoplasia and Hormonal Disorders and Department of Pediatrics-Patient Care, Children's Cancer Hospital, University of Texas MD Anderson Cancer Center , Houston, Texas. · 3 Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania.; 4 Department of Pediatrics, The University of Pennsylvania , The Perelman School of Medicine, Philadelphia, Pennsylvania. · 5 Section of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine , Chicago, Illinois. · 6 University of Messina , Interdepartmental Program on Clinical & Molecular Endocrinology, and Women's Endocrine Health, A.O.U. Policlinico Universitario G. Martino, Messina, Italy . · 7 Department of Morphology and Genetics. Division of Genetics, Federal University of São Paulo , São Paulo, Brazil . · 8 Department of Surgery, Division of Pediatric Surgery, Department of Pediatrics, Division of Pediatric Endocrinology, Yale University School of Medicine , New Haven, Connecticut. · 9 Division of Endocrinology, University of Toronto , Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada . · 10 Division of Endocrinology, Mayo Clinic and College of Medicine , Rochester, Minnesota. · 11 University of Marburg , Marburg, Germany .; 12 Department of Nuclear Medicine, University Hospital Marburg , Marburg, Germany . · 13 Departments of Radiology and Pediatrics, University of Washington School of Medicine and Seattle Children's Hospital , Department of Radiology, Seattle, Washington. · 14 Pediatric Division, Assaf Haroffeh Medical Center , Zerifin, Israel .; 15 Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel . · 16 Department of Surgery, Division of Subspecialty GS (General Surgery), Mayo Clinic , Rochester, Minnesota. · 17 Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan . · ·Thyroid · Pubmed #25900731.

ABSTRACT: BACKGROUND: Previous guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death but at higher risk for long-term harm from overly aggressive treatment. For these reasons, unique guidelines for children and adolescents with thyroid tumors are needed. METHODS: A task force commissioned by the American Thyroid Association (ATA) developed a series of clinically relevant questions pertaining to the management of children with thyroid nodules and differentiated thyroid cancer (DTC). Using an extensive literature search, primarily focused on studies that included subjects ≤18 years of age, the task force identified and reviewed relevant articles through April 2014. Recommendations were made based upon scientific evidence and expert opinion and were graded using a modified schema from the United States Preventive Services Task Force. RESULTS: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with DTC are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided. CONCLUSIONS: In response to our charge as an independent task force appointed by the ATA, we developed recommendations based on scientific evidence and expert opinion for the management of thyroid nodules and DTC in children and adolescents. In our opinion, these represent the current optimal care for children and adolescents with these conditions.

18 Guideline Modern radiation therapy for extranodal lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group. 2015

Yahalom, Joachim / Illidge, Tim / Specht, Lena / Hoppe, Richard T / Li, Ye-Xiong / Tsang, Richard / Wirth, Andrew / Anonymous8110826. ·Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York. Electronic address: yahalomj@mskcc.org. · Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Sciences Centre, The Christie National Health Service Foundation Trust, Manchester, United Kingdom. · Department of Oncology and Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. · Department of Radiation Oncology, Stanford University, Palo Alto, California. · Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. · Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada. · Division of Radiation Oncology, Peter MacCallum Cancer Institute, St. Andrews Place, East Melbourne, Australia. · ·Int J Radiat Oncol Biol Phys · Pubmed #25863750.

ABSTRACT: Extranodal lymphomas (ENLs) comprise about a third of all non-Hodgkin lymphomas (NHL). Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation. The wide range of presentations of ENL, involving any organ in the body and the spectrum of histological sub-types, poses a challenge both for routine clinical care and for the conduct of prospective and retrospective studies. This has led to uncertainty and lack of consistency in RT approaches between centers and clinicians. Thus far there is a lack of guidelines for the use of RT in the management of ENL. This report presents an effort by the International Lymphoma Radiation Oncology Group (ILROG) to harmonize and standardize the principles of treatment of ENL, and to address the technical challenges of simulation, volume definition and treatment planning for the most frequently involved organs. Specifically, detailed recommendations for RT volumes are provided. We have applied the same modern principles of involved site radiation therapy as previously developed and published as guidelines for Hodgkin lymphoma and nodal NHL. We have adopted RT volume definitions based on the International Commission on Radiation Units and Measurements (ICRU), as has been widely adopted by the field of radiation oncology for solid tumors. Organ-specific recommendations take into account histological subtype, anatomy, the treatment intent, and other treatment modalities that may be have been used before RT.

19 Guideline Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. 2015

Wells, Samuel A / Asa, Sylvia L / Dralle, Henning / Elisei, Rossella / Evans, Douglas B / Gagel, Robert F / Lee, Nancy / Machens, Andreas / Moley, Jeffrey F / Pacini, Furio / Raue, Friedhelm / Frank-Raue, Karin / Robinson, Bruce / Rosenthal, M Sara / Santoro, Massimo / Schlumberger, Martin / Shah, Manisha / Waguespack, Steven G / Anonymous770898. ·1Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. · 2Department of Pathology, University Health Network, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. · 3Department of General, Visceral, and Vascular Surgery, University Hospital, University of Halle-Wittenberg, Halle/Saale, Germany. · 4Department of Endocrinology, University of Pisa, Pisa, Italy. · 5Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. · 6Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. · 7Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York. · 8Department of Surgery, Washington University School of Medicine, St. Louis, Missouri. · 9Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy. · 10Endocrine Practice, Moleculargenetic Laboratory, Medical Faculty, University of Heidelberg, Heidelberg, Germany. · 11University of Sydney School of Medicine, Sydney, New South Wales, Australia. · 12Departments of Internal Medicine, Pediatrics and Behavioral Science, University of Kentucky, Lexington, Kentucky. · 13Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita' di Napoli "Federico II," Napoli, Italy. · 14Institut Gustave Roussy, Service de Medecine Nucleaire, Université of Paris-Sud, Villejuif, France. · 15Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio. · ·Thyroid · Pubmed #25810047.

ABSTRACT: INTRODUCTION: The American Thyroid Association appointed a Task Force of experts to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the American Thyroid Association. METHODS: The Task Force identified relevant articles using a systematic PubMed search, supplemented with additional published materials, and then created evidence-based recommendations, which were set in categories using criteria adapted from the United States Preventive Services Task Force Agency for Healthcare Research and Quality. The original guidelines provided abundant source material and an excellent organizational structure that served as the basis for the current revised document. RESULTS: The revised guidelines are focused primarily on the diagnosis and treatment of patients with sporadic medullary thyroid carcinoma (MTC) and hereditary MTC. CONCLUSIONS: The Task Force developed 67 evidence-based recommendations to assist clinicians in the care of patients with MTC. The Task Force considers the recommendations to represent current, rational, and optimal medical practice.

20 Guideline Practice Bulletin No. 148: Thyroid disease in pregnancy. 2015

Anonymous7190824. · ·Obstet Gynecol · Pubmed #25798985.

ABSTRACT: -- No abstract --

21 Guideline Screening for thyroid dysfunction: U.S. Preventive Services Task Force recommendation statement. 2015

LeFevre, Michael L / Anonymous7150824. · ·Ann Intern Med · Pubmed #25798805.

ABSTRACT: DESCRIPTION: Update of the 2004 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for thyroid disease. METHODS: The USPSTF reviewed the evidence on the benefits and harms of screening for subclinical and "overt" thyroid dysfunction without clinically obvious symptoms, as well as the effects of treatment on intermediate and final health outcomes. POPULATION: This recommendation applies to nonpregnant, asymptomatic adults. RECOMMENDATION: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for thyroid dysfunction in nonpregnant, asymptomatic adults. (I statement).

22 Guideline Consensus on the management of advanced medullary thyroid carcinoma on behalf of the Working Group of Thyroid Cancer of the Spanish Society of Endocrinology (SEEN) and the Spanish Task Force Group for Orphan and Infrequent Tumors (GETHI). 2015

Galofré, Juan C / Santamaría Sandi, Javier / Capdevila, Jaume / Navarro González, Elena / Zafón Llopis, Carles / Ramón Y Cajal Asensio, Teresa / Gómez Sáez, José Manuel / Jiménez-Fonseca, Paula / Riesco Eizaguirre, Garcilaso / Grande, Enrique. ·Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Spain. Electronic address: jcgalofre@unav.es. · Service of Endocrinology and Nutrition, Hospital Universitario de Cruces, Vizcaya, Spain. · Service of Medical Oncology, Hospital Universitario de la Vall d'Hebron, Barcelona, Spain. · Service of Endocrinology and Nutrition, Hospital Universitario Virgen del Rocio, Sevilla, Spain. · Service of Endocrinology and Nutrition, Hospital Universitario de la Vall d'Hebron, Barcelona, Spain. · Service of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. · CIBERDEM Service of Endocrinology and Nutrition, Hospital Universitario de Bellvitge, Spain. · Service of Medical Oncology, Hospital Universitario Central de Asturias, Oviedo, Spain. · Service of Endocrinology and Nutrition, Hospital Universitario de Móstoles, Madrid, Spain. · Service of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain. ·Endocrinol Nutr · Pubmed #25732322.

ABSTRACT: BACKGROUND: In Spain medullary thyroid carcinoma (MTC) would not exceed 80 new cases per year and less than half of them would be good candidates for systemic treatment with novel agents. METHODS: Relevant literature was reviewed, including PubMed searches supplemented with additional articles. RESULTS: The consensus summarizes the clinical outcomes in terms of activity and toxicity of each of the available drugs. A brief summary of the minimum requirements in terms of follow up and genetic counseling around MTC is also included. CONCLUSIONS: Only those patients with objective imaging progression in the last 12-14 months with large volume of disease are clear candidates to start systemic treatment. However, those patients with low disease volume should be considered for 'wait and see' strategy until symptoms of the disease appear. Multidisciplinary approach for the management of MTC patient is mandatory nowadays.

23 Guideline [Thyroid dysfunction in pregnancy. Consensus document. Andalusian Society of Endocrinology and Nutrition (SAEN)]. 2015

Santiago Fernández, P / González-Romero, S / Martín Hernández, T / Navarro González, E / Velasco López, I / Millón Ramírez, M C. ·Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Jaén, Jaén, España. Electronic address: Santiago11@ono.com. · Servicio de Endocrinología y Nutrición, Hospital Regional de Málaga, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), CIBER de Diabetes y Enfermedades Metabólicas, Málaga, España. · Servicio de Endocrinología y Nutrición, Hospital Virgen Macarena, Sevilla, España. · Servicio de Endocrinología y Nutrición, Hospital Virgen del Rocío, Sevilla, España. · Servicio de Ginecología y Obstetricia, Hospital de Riotinto, Huelva, España. · Unidad de Gestión Clínica (UGC) Axarquía-Norte, Área de Gestión Sanitaria (AGS) Este de Málaga-Axarquia, Málaga, España. ·Semergen · Pubmed #25700854.

ABSTRACT: A position statement on the diagnosis and treatment of thyroid dysfunction in pregnancy has been agreed on behalf of The Sociedad Andaluza de Endocrinología y Nutrición (SAEN), based on a review of the literature to date and all good clinical practice guidelines. The document is set out in different sections as regards the diagnosis and treatment of, overt and subclinical hypo- and hyperthyroidism, isolated hypothyroxinaemia and postpartum thyroiditis. It also justifies the implementation of universal screening for thyroid dysfunction in pregnancy, and provides practitioners who care for these patients with tool for rational decision making.

24 Guideline Management of recurrent/persistent nodal disease in patients with differentiated thyroid cancer: a critical review of the risks and benefits of surgical intervention versus active surveillance. 2015

Tufano, Ralph P / Clayman, Gary / Heller, Keith S / Inabnet, William B / Kebebew, Electron / Shaha, Ashok / Steward, David L / Tuttle, R Michael / Anonymous3830807. ·1 Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland. · ·Thyroid · Pubmed #25246079.

ABSTRACT: BACKGROUND: The primary goals of this interdisciplinary consensus statement are to define the eligibility criteria for management of recurrent and persistent cervical nodal disease in patients with differentiated thyroid cancer (DTC) and to review the risks and benefits of surgical intervention versus active surveillance. METHODS: A writing group was convened by the Surgical Affairs Committee of the American Thyroid Association and was tasked with identifying the important clinical elements to consider when managing recurrent/persistent nodal disease in patients with DTC based on the available evidence in the literature and the group's collective experience. SUMMARY: The decision on how best to manage individual patients with suspected recurrent/persistent nodal disease is challenging and requires the consideration of a significant number of variables outlined by the members of the interdisciplinary team. Here we report on the consensus opinions that were reached by the writing group regarding the technical and clinical issues encountered in this patient population. CONCLUSIONS: Identification of recurrent/persistent disease requires a team decision-making process that includes the patient and physicians as to what, if any, intervention should be performed to best control the disease while minimizing morbidity. Several management principles and variables involved in the decision making for surgery versus active surveillance were developed that should be taken into account when deciding how best to manage a patient with DTC and suspected recurrent or persistent cervical nodal disease.

25 Guideline American Thyroid Association statement on preoperative imaging for thyroid cancer surgery. 2015

Yeh, Michael W / Bauer, Andrew J / Bernet, Victor A / Ferris, Robert L / Loevner, Laurie A / Mandel, Susan J / Orloff, Lisa A / Randolph, Gregory W / Steward, David L / Anonymous3061060. ·1 Section of Endocrine Surgery, UCLA David Geffen School of Medicine , Los Angeles, California. · ·Thyroid · Pubmed #25188202.

ABSTRACT: BACKGROUND: The success of surgery for thyroid cancer hinges on thorough and accurate preoperative imaging, which enables complete clearance of the primary tumor and affected lymph node compartments. This working group was charged by the Surgical Affairs Committee of the American Thyroid Association to examine the available literature and to review the most appropriate imaging studies for the planning of initial and revision surgery for thyroid cancer. SUMMARY: Ultrasound remains the most important imaging modality in the evaluation of thyroid cancer, and should be used routinely to assess both the primary tumor and all associated cervical lymph node basins preoperatively. Positive lymph nodes may be distinguished from normal nodes based upon size, shape, echogenicity, hypervascularity, loss of hilar architecture, and the presence of calcifications. Ultrasound-guided fine-needle aspiration of suspicious lymph nodes may be useful in guiding the extent of surgery. Cross-sectional imaging (computed tomography with contrast or magnetic resonance imaging) may be considered in select circumstances to better characterize tumor invasion and bulky, inferiorly located, or posteriorly located lymph nodes, or when ultrasound expertise is not available. The above recommendations are applicable to both initial and revision surgery. Functional imaging with positron emission tomography (PET) or PET-CT may be helpful in cases of recurrent cancer with positive tumor markers and negative anatomic imaging.

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