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Trabecular Meshwork HELP
Based on 1,333 articles published since 2010
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These are the 1333 published articles about Trabecular Meshwork that originated from Worldwide during 2010-2020.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Editorial Time, the great physician. 2014

Wells, Tony. ·Capital Eye Specialists, Wellington, New Zealand; Wellington School of Medicine, University of Otago, Wellington, New Zealand; Wellington Hospital Eye Department, Wellington, New Zealand. ·Clin Exp Ophthalmol · Pubmed #25053510.

ABSTRACT: -- No abstract --

2 Editorial Emerging trabecular outflow drugs. 2014

Kopczynski, Casey C / Epstein, David L. ·1 Aerie Pharmaceuticals , Research Triangle Park, North Carolina. ·J Ocul Pharmacol Ther · Pubmed #24304197.

ABSTRACT: -- No abstract --

3 Editorial [Ultrastructural changes in the trabecular meshwork and increased IOP. Which came first, the chicken or the egg?]. 2011

Galdos, M / Vecino, E. · ·Arch Soc Esp Oftalmol · Pubmed #21821189.

ABSTRACT: -- No abstract --

4 Editorial 'So what's our angle on this?'. 2010

Walland, Mark J / Thomas, Ravi. · ·Clin Exp Ophthalmol · Pubmed #21050347.

ABSTRACT: -- No abstract --

5 Editorial Progress towards understanding the functioning of the trabecular meshwork based on lessons from studies of laser trabeculoplasty. 2010

Alvarado, Jorge A / Shifera, Amde Selassie. · ·Br J Ophthalmol · Pubmed #20962351.

ABSTRACT: -- No abstract --

6 Editorial The iris is a sponge: a cause of angle closure. 2010

Quigley, Harry A. · ·Ophthalmology · Pubmed #20114108.

ABSTRACT: -- No abstract --

7 Review Circumferential canal surgery: a brief history. 2020

Dickerson, Jaime E / Brown, Reay H. ·Sight Sciences Inc., Menlo Park, California. · North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas. · Atlanta Ophthalmology Associates, Atlanta, Georgia, USA. ·Curr Opin Ophthalmol · Pubmed #31904595.

ABSTRACT: PURPOSE OF REVIEW: Most microinvasive glaucoma surgery (MIGS) procedures bypass outflow resistance residing proximally in the trabecular meshwork and inner wall of Schlemm's canal. A novel procedure combining trabeculotomy with viscodilation adds to this by also addressing distal resistance of the canal and collector channel ostia. This review examines the development and evidence for both trabeculotomy and canaloplasty separately and the combination in a single procedure. RECENT FINDINGS: Recent aqueous angiography studies have confirmed the segmental nature of outflow through Schlemm's canal highlighting the need to address distal outflow pathway resistance. Combined trabeculotomy and viscodilation ab interno is a novel approach with a new purpose-designed device (OMNI Surgical System) becoming available to surgeons in early 2018. Recent results as both a standalone and combined with cataract procedure demonstrate significant intraocular pressure reductions with an average 41% reduction from baseline in the pseudophakic group. SUMMARY: Targeting both distal as well as proximal points of outflow resistance in the conventional pathway may prove to be a highly efficacious MIGS modality. Additional large prospective studies are currently ongoing to confirm these preliminary results.

8 Review [360° trabeculotomy for pediatric glaucoma]. 2020

Hoffmann, Esther M. ·Deutsches Kinder Glaukomzentrum Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland. ehoffman@uni-mainz.de. ·Ophthalmologe · Pubmed #31713654.

ABSTRACT: Congenital glaucoma disease leads to blindness if left untreated. It is estimated that 1 child in 10,000 in Germany is born with congenital glaucoma. In adults the disease develops slowly and insidiously, whereas congenital glaucoma leads to a rapid growth of the eye (buphthalmos) mostly directly after birth due to a very high intraocular pressure. The cause is dysgenesis of the iridocorneal angle. Successful operative treatment of congenital glaucoma is possible in the majority of cases (approximately 80-90%). The treatment of childhood glaucoma is primarily surgical. Since 1960 classical probe trabeculotomy has been the most commonly used procedure, which has the advantage that unlike goniotomy, it can also be performed in cases with clouding of the cornea. In this surgery the canal of Schlemm is probed and the inner wall as well as the trabecular meshwork is opened inwardly over approximately 120°. In recent years the 360° trabeculotomy procedure has become established, in which an illuminated catheter filled with viscoelastic material is used (as with conventional canaloplasty) to dilate the canal of Schlemm. The trabecular meshwork is then inwardly opened by pulling on the ends of the catheter. The results of this method are explained in this article.

9 Review How many aqueous humor outflow pathways are there? 2020

Costagliola, Ciro / dell'Omo, Roberto / Agnifili, Luca / Bartollino, Silvia / Fea, Antonio M / Uva, Maurizio G / Zeppa, Lucio / Mastropasqua, Leonardo. ·Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy. · Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy. Electronic address: l.agnifili@unich.it. · Department of Surgical Sciences, University of Torino, Torino, Italy. · Eye Clinic, University of Catania, Catania, Italy. · Department of Ophthalmology, G. Moscati Hospital, Avellino, Italy. · Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy. ·Surv Ophthalmol · Pubmed #31622628.

ABSTRACT: The aqueous humor (AH) outflow pathways definition is still matter of intense debate. To date, the differentiation between conventional (trabecular meshwork) and unconventional (uveoscleral) pathways is widely accepted, distinguishing the different impact of the intraocular pressure on the AH outflow rate. Although the conventional route is recognized to host the main sites for intraocular pressure regulation, the unconventional pathway, with its great potential for AH resorption, seems to act as a sort of relief valve, especially when the trabecular resistance rises. Recent evidence demonstrates the presence of lymphatic channels in the eye and proposes that they may participate in the overall AH drainage and intraocular pressure regulation, in a presumably adaptive fashion. For this reason, the uveolymphatic route is increasingly thought to play an important role in the ocular hydrodynamic system physiology. As a result of the unconventional pathway characteristics, hydrodynamic disorders do not develop until the adaptive routes cannot successfully counterbalance the increased AH outflow resistance. When their adaptive mechanisms fail, glaucoma occurs. Our review deals with the standard and newly discovered AH outflow routes, with particular attention to the importance they may have in opening new therapeutic strategies in the treatment of ocular hypertension and glaucoma.

10 Review Netarsudil and latanoprost ophthalmic solution for the reduction of intraocular pressure in open-angle glaucoma or ocular hypertension. 2019

Aref, Ahmad A / Geyman, Lawrence S / Zakieh, Abdel-Rahman / Alotaibi, Humoud M. ·Department of Ophthalmology and Visual Sciences, Illinois Eye & Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, IL, USA. · Chicago Medical School, Rosalind Franklin University, Chicago, IL, USA. · King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. ·Expert Rev Clin Pharmacol · Pubmed #31842637.

ABSTRACT:

11 Review Role of Fibronectin in Primary Open Angle Glaucoma. 2019

Faralli, Jennifer A / Filla, Mark S / Peters, Donna M. ·Departments of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA. · Ophthalmology & Visual Sciences, University of Wisconsin, Madison, WI 53706, USA. ·Cells · Pubmed #31779192.

ABSTRACT: Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd most common cause of irreversible vision loss in the United States. Nearly 67 million people have the disease worldwide including >3 million in the United States. A major risk factor for POAG is an elevation in intraocular pressure (IOP). The increase in IOP is believed to be caused by an increase in the deposition of extracellular matrix proteins, in particular fibronectin, in a region of the eye known as the trabecular meshwork (TM). How fibronectin contributes to the increase in IOP is not well understood. The increased density of fibronectin fibrils is thought to increase IOP by altering the compliance of the trabecular meshwork. Recent studies, however, also suggest that the composition and organization of fibronectin fibrils would affect IOP by changing the cell-matrix signaling events that control the functional properties of the cells in the trabecular meshwork. In this article, we will discuss how changes in the properties of fibronectin and fibronectin fibrils could contribute to the regulation of IOP.

12 Review Promising Approach in the Treatment of Glaucoma Using Nanotechnology and Nanomedicine-Based Systems. 2019

Juliana, Fidiniaina Rina / Kesse, Samuel / Boakye-Yiadom, Kofi Oti / Veroniaina, Hanitrarimalala / Wang, Huihui / Sun, Meihao. ·College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China. younitra@gmail.com. · School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. kessejnr@yahoo.com. · Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China. kessejnr@yahoo.com. · School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. otiboakye1000@gmail.com. · Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China. otiboakye1000@gmail.com. · State Key Laboratory of Modern Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China. scholarha@yahoo.com. · College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China. sanket.acharya4@gmail.com. · College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China. mhsun@zjnu.cn. ·Molecules · Pubmed #31652593.

ABSTRACT: Glaucoma is considered a leading cause of blindness with the human eye being one of the body's most delicate organs. Ocular diseases encompass diverse diseases affecting the anterior and posterior ocular sections, respectively. The human eye's peculiar and exclusive anatomy and physiology continue to pose a significant obstacle to researchers and pharmacologists in the provision of efficient drug delivery. Though several traditional invasive and noninvasive eye therapies exist, including implants, eye drops, and injections, there are still significant complications that arise which may either be their low bioavailability or the grave ocular adverse effects experienced thereafter. On the other hand, new nanoscience technology and nanotechnology serve as a novel approach in ocular disease treatment. In order to interact specifically with ocular tissues and overcome ocular challenges, numerous active molecules have been modified to react with nanocarriers. In the general population of glaucoma patients, disease growth and advancement cannot be contained by decreasing intraocular pressure (IOP), hence a spiking in future research for novel drug delivery systems and target therapeutics. This review focuses on nanotechnology and its therapeutic and diagnostic prospects in ophthalmology, specifically glaucoma. Nanotechnology and nanomedicine history, the human eye anatomy, research frontiers in nanomedicine and nanotechnology, its imaging modal quality, diagnostic and surgical approach, and its possible application in glaucoma will all be further explored below. Particular focus will be on the efficiency and safety of this new therapy and its advances.

13 Review Update on the usefulness of optical coherence tomography in assessing the iridocorneal angle. 2019

Kudsieh, B / Fernández-Vigo, J I / Vila-Arteaga, J / Urcola, J Aritz / Martínez-de-la-Casa, J M / García-Feijóo, J / Ruiz-Moreno, J M / Fernández-Vigo, J Á. ·Departamento de Oftalmología, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, España; Centro Internacional de Oftalmología Avanzada, Madrid, España. Electronic address: bacharkudsieh@gmail.com. · Centro Internacional de Oftalmología Avanzada, Madrid, España; Departamento de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, España. · Hospital La Fe, Valencia, España; Clínica Vila-Innova Ocular, Valencia, España. · Departamento de Oftalmología, Hospital Universitario de Álava, Vitoria, España; Begitek Clínica Oftalmológica, Innova Ocular, Donostia-San Sebastián, España. · Departamento de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, España. · Departamento de Oftalmología, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, España. · Centro Internacional de Oftalmología Avanzada, Madrid, España; Departamento de Oftalmología, Universidad de Extremadura, Badajoz, España. ·Arch Soc Esp Oftalmol · Pubmed #31371112.

ABSTRACT: The iridocorneal angle, due to its implications in the physiopathology of aqueous humour drainage, is a fundamental structure of the anterior chamber. Anterior segment optical coherence tomography is a rapid and non-invasive technique that obtains images in vivo. The high resolution allows it to analyse the normal anatomy of the angle, any alterations, and the changes that occur after different therapeutic interventions. Anterior segment optical coherence tomography technology has evolved to provide images that allow the identification and quantification of the angular structures in healthy subjects and in glaucoma patients, and especially the trabecular meshwork and the Schlemm's canal. It also enables the angle width to be quantified, with some objective parameters that have been standardised in recent years, such as the trabecular-iris angle, the angle opening distance, and the trabecular-iris area. This technique has multiple uses in the study of the different mechanisms of angle closure, the evaluation of changes after a laser peripheral iridotomy or iridoplasty after cataract surgery, as well as after the implantation of phakic lenses.

14 Review Human Trabecular Meshwork Progenitors. 2019

Zhu, Qin / Zhang, Yuan / Tighe, Sean / Liu, Yongsong / Zhu, Yingting / Hu, Min. ·Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University (the Second People's Hospital of Yunnan Province); Yunnan Eye Institute; Key Laboratory of Yunnan Province for the Prevention and Treatment of ophthalmology (2017DG008); Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People's Hospital of Yunnan Province (2017HC010); Expert Workstation of Yao Ke (2017IC064), Kunming 650021, China. · Tissue Tech, Inc., Ocular Surface Center, and Ocular Surface Research & Education Foundation, Miami, FL, 33173 USA. · Department of Ophthalmology, Yan' An Hospital of Kunming City, Kunming, 650051, China. ·Int J Med Sci · Pubmed #31217738.

ABSTRACT: Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwork diseases such as glaucoma, corneal endothelial dysfunctions such as blindness due to corneal endothelial dysfunction, and similar diseases. In order to promote the understanding of human trabecular meshwork progenitors, this article reviews human trabecular meshwork progenitor therapy and discusses its potential applications for curing human eye blindness.

15 Review Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye? 2019

Patterson-Orazem, Athéna C / Lieberman, Raquel L. ·School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States. ·Invest Ophthalmol Vis Sci · Pubmed #31067323.

ABSTRACT: Antibodies are key reagents used in vision research, indeed across biomedical research, but they often do not reveal the whole story about a sample. It is important for researchers to be aware of aspects of antibodies that may affect or limit data interpretation. Federal agencies now require funded grants to demonstrate how they will authenticate reagents used. There is also a push for recombinant antibodies, enabled by phage display technology awarded the 2018 Nobel Prize in Chemistry, which allow for thorough validation and a fixed DNA sequence. Here, we discuss how issues surrounding antibodies are pertinent to detecting myocilin, a protein found in trabecular meshwork and associated with a portion of hereditary glaucoma. Confirmation of myocilin expression in tissues and cell culture has been adopted as validation standard in trabecular meshwork research; thus, a discussion of antibody characteristics and fidelity is critical. Further, based on our basic structural understanding of myocilin architecture and its biophysical aggregation properties, we provide a wish list for the characteristics of next-generation antibody reagents for vision researchers. In the long term, well-characterized antibodies targeting myocilin will enable new insights into its function and involvement in glaucoma pathogenesis.

16 Review Visual Defects and Ageing. 2019

Saccà, Sergio Claudio / Cutolo, Carlo Alberto / Rossi, Tommaso. ·Department of Head/Neck Pathologies, St Martino Hospital, Ophthalmology Unit, Genoa, Italy. sergio.sacca@hsanmartino.it. · Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Science, University of Genoa, Policlinico San Martino Hospital, Eye Clinic Genoa, Genoa, Italy. · Department of Head/Neck Pathologies, St Martino Hospital, Ophthalmology Unit, Genoa, Italy. ·Subcell Biochem · Pubmed #30888660.

ABSTRACT: Many diseases are related to age, among these neurodegeneration is particularly important. Alzheimer's disease Parkinson's and Glaucoma have many common pathogenic events including oxidative damage, Mitochondrial dysfunction, endothelial alterations and changes in the visual field. These are well known in the case of glaucoma, less in the case of neurodegeneration of the brain. Many other molecular aspects are common, such as the role of endoplasmic reticulum autophagy and neuronal apoptosis while others have been neglected due to lack of space such as inflammatory cytokine or miRNA. Moreover, the loss of specific neuronal populations, the induction of similar mechanisms of cell injury and the deposition of protein aggregates in specific anatomical areas are very similar events between these diseases. Intracellular and/or extracellular accumulation of protein aggregates is a key feature of many neurodegenerative disorders. The existence of abnormal protein aggregates has been documented in the RGCs of glaucomatous patients such as the anomalous Tau protein or the β-amyloid accumulations. Intra-cell catabolic processes also appear to be common in both glaucoma and neurodegeneration. They also help us to understand how the basis between these diseases is common and how the visual aspects can be a serious problem for those who are affected.

17 Review Rho kinase inhibitors-a review on the physiology and clinical use in Ophthalmology. 2019

Moura-Coelho, Nuno / Tavares Ferreira, Joana / Bruxelas, Carolina Pereira / Dutra-Medeiros, Marco / Cunha, João Paulo / Pinto Proença, Rita. ·Ophthalmology Department, Centro Hospitalar Universitário Lisboa Central (CHULC), Alameda Santo António Capuchos, 1169-050, Lisbon, Portugal. nunomouracoelho.oft@gmail.com. · Faculty of Medical Sciences|NOVA Medical School-Nova University of Lisbon (FCM|NMS-UNL), Lisbon, Portugal. nunomouracoelho.oft@gmail.com. · Instituto Português de Retina (IPR), Lisbon, Portugal. nunomouracoelho.oft@gmail.com. · Associação Médica Olhar Bem (AMO Bem), Lisbon, Portugal. nunomouracoelho.oft@gmail.com. · Ophthalmology Department, Centro Hospitalar Universitário Lisboa Central (CHULC), Alameda Santo António Capuchos, 1169-050, Lisbon, Portugal. · Faculty of Medical Sciences|NOVA Medical School-Nova University of Lisbon (FCM|NMS-UNL), Lisbon, Portugal. · Associação Médica Olhar Bem (AMO Bem), Lisbon, Portugal. · Ophthalmology Department, Ocidental Lisbon Hospital Center (CHLO), Lisbon, Portugal. · Instituto Português de Retina (IPR), Lisbon, Portugal. · Associação Protectora dos Diabéticos de Portugal (APDP), Lisbon, Portugal. · Faculdade de Medicina de Lisboa-Universidade de Lisboa (FML-UL), Lisbon, Portugal. ·Graefes Arch Clin Exp Ophthalmol · Pubmed #30843105.

ABSTRACT: The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.

18 Review Substances of Interest That Support Glaucoma Therapy. 2019

Saccà, Sergio Claudio / Corazza, Paolo / Gandolfi, Stefano / Ferrari, Daniele / Sukkar, Samir / Iorio, Eugenio Luigi / Traverso, Carlo Enrico. ·Ophthalmology Unit, Department of Head/Neck Pathologies, Policlinico San Martino Hospital, IRCCS Hospital-University San Martino, Viale Benedetto XV, 16132 Genoa, Italy. sergio.sacca@hsanmartino.it. · Eye Clinic, Department of Neuroscience and Sensory Organs, University of Genoa, Policlinico San Martino Hospital IRCCS Hospital-University San Martino, Viale Benedetto XV, 16132 Genoa, Italy. polcorazza@gmail.com. · Ophthalmology Unit, Department of Biological, Biotechnological and Translational Sciences, University of Parma, 43121 Parma, Italy. s.gandolfi@rsadvnet.it. · Ophthalmology Unit, Department of Head/Neck Pathologies, Policlinico San Martino Hospital, IRCCS Hospital-University San Martino, Viale Benedetto XV, 16132 Genoa, Italy. ferraridaniele92@gmail.com. · U.O. di Dietetica e Nutrizione Clinica, Policlinico San Martino Hospital IRCCS Hospital-University San Martino, 35122 Genoa, Italy. samir.sukkar@hsanmartino.it. · International Observatory of Oxidative Stress, Via Paolo Grisignano 21, 84127 Salerno, Italy. samir.sukkar@hsanmartino.it. · Eye Clinic, Department of Neuroscience and Sensory Organs, University of Genoa, Policlinico San Martino Hospital IRCCS Hospital-University San Martino, Viale Benedetto XV, 16132 Genoa, Italy. eugenioluigi.iorio@gmail.com. ·Nutrients · Pubmed #30678262.

ABSTRACT: Glaucoma is a multifactorial disease in which pro-apoptotic signals are directed to retinal ganglion cells. During this disease the conventional outflow pathway becomes malfunctioning. Aqueous humour builds up in the anterior chamber, leading to increased intraocular pressure. Both of these events are related to functional impairment. The knowledge of molecular mechanisms allows us to better understand the usefulness of substances that can support anti-glaucoma therapy. The goal of glaucoma therapy is not simply to lower intraocular pressure; it should also be to facilitate the survival of retinal ganglion cells, as these constitute the real target tissue in this disease, in which the visual pathway is progressively compromised. Indeed, an endothelial dysfunction syndrome affecting the endothelial cells of the trabecular meshwork occurs in both normal-tension glaucoma and high-tension glaucoma. Some substances, such as polyunsaturated fatty acids, can counteract the damage due to the molecular mechanisms - whether ischemic, oxidative, inflammatory or other - that underlie the pathogenesis of glaucoma. In this review, we consider some molecules, such as polyphenols, that can contribute, not only theoretically, to neuroprotection but which are also able to counteract the metabolic pathways that lead to glaucomatous damage. Ginkgo biloba extract, for instance, improves the blood supply to peripheral districts, including the optic nerve and retina and exerts a neuro-protective action by inhibiting apoptosis. Polyunsaturated fatty acids can protect the endothelium and polyphenols exert an anti-inflammatory action through the down-regulation of cytokines such as TNF-α and IL-6. All these substances can aid anti-glaucoma therapy by providing metabolic support for the cells involved in glaucomatous injury. Indeed, it is known that the food we eat is able to change our gene expression.

19 Review Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma. 2019

Sun, Hong / Zhu, Qin / Guo, Ping / Zhang, Yuan / Tighe, Sean / Zhu, Yingting. ·Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. · Department of Ophthalmology, the Second People's Hospital of Yunnan Province (Fourth Affiliated Hospital of Kunming Medical University), Yunnan Eye Institute, Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology (2017DG008), Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People's Hospital of Yunnan Province (2017HC010), Expert Workstation of Yao Ke (2017IC064), Kunming, China. · Shenzhen University School of Medicine, Shenzhen Eye Hospital, Shenzhen, China. · Tissue Tech, Inc., Ocular Surface Center, Ocular Surface Research & Education Foundation, Miami, Florida. ·J Cell Mol Med · Pubmed #30659738.

ABSTRACT: Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as a cell-based therapy to prevent blindness caused by glaucoma, corneal endothelial dysfunction and other diseases in general. In this review, we review in vitro expansion techniques for TM progenitors, discuss their phenotypic properties, and highlight their potential clinical applications in various ophthalmic diseases.

20 Review [Kahook Dual Blade : An instrument for microincisional trabecular meshwork surgery]. 2019

van Oterendorp, C / Bahlmann, D. ·Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. christian.oterendorp@med.uni-goettingen.de. · Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. ·Ophthalmologe · Pubmed #30643950.

ABSTRACT: The Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA, USA) is a novel goniotomy instrument for opening Schlemm's canal. Performing the procedure is comparable to the Trabectome (Neomedix, Tustin, CA, USA) under gonioscopic control with the major difference that the trabeculectomy is created by a dual blade instead of electroablation. The currently available clinical data are limited to a small number of retrospective studies with ≤1 year of follow-up. Based on these data and in line with the author's personal experience, the Kahook Dual Blade seems comparable to the Trabectome regarding effectiveness as well as intraoperative and postoperative complications, such as intraocular pressure (IOP) elevation and hyphema.

21 Review Roles of Toll-Like Receptor 4 for Cellular Pathogenesis in Primary Open-Angle Glaucoma: A potential therapeutic strategy. 2019

Poyomtip, Teera. ·Faculty of Optometry, Ramkhamhaeng University, Bangkok, Thailand. Electronic address: tpteera075@gmail.com. ·J Microbiol Immunol Infect · Pubmed #30612922.

ABSTRACT: In recent years, glaucoma has been proposed as an autoimmune disease and an understanding immune-regulation concept has been applied for novel glaucoma therapy. Current evidence suggests an innate immunity is a keystone step for primary open angle glaucoma (POAG) pathogenesis resulting from trabecular meshwork (TM) cell fibrosis and retinal ganglion cell (RGC) death. Toll-like receptor 4 (TLR4) is a common player in the innate immunity, which appears on the TM and RGC of POAG. The activation of TLR4 regulates several molecules involving both fibrosis and cell death. Inhibition of TLR4 decreases TGF-β2-induced fibrosis in TM cells and enhances cell survival of RGC in both optic nerve crush and ischemia models. In this review, we will summarize the molecular mechanisms of TLR4 related to POAG pathogenesis. An understanding of this mechanism may provide novel development of therapeutic strategies for POAG.

22 Review Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review). 2019

Wang, Hongwei / Li, Mingzhe / Zhang, Zhenzhen / Xue, Haifeng / Chen, Xing / Ji, Yong. ·Department of Ophthalmology, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China. · Department of Ophthalmology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China. · Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China. · Public Health School, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China. · Department of Science and Education, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China. · Department of General Surgery, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China. ·Int J Mol Med · Pubmed #30483726.

ABSTRACT: Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction of the TM, potentially leading to increased IOP. High IOP is a well‑known primary risk factor for glaucoma. Myocilin mutations are common among glaucoma patients, and they are implicated in juvenile‑onset open‑angle glaucoma (JOAG) and adult‑onset primary open‑angle glaucoma (POAG). Aggregation of aberrant mutant myocilins is closely associated with glaucoma pathogenesis. The aim of the present review was to discuss the recent findings regarding the major physiological functions of myocilin, such as intra‑ and extracellular proteolytic processes. We also aimed to discuss the risk factors associated with myocilin and the development of glaucoma, such as misfolded/mutant myocilin, imbalance of myocilin and extracellular proteins, and instability of mutant myocilin associated with temperature. Finally, we further outlined certain issues that are yet to be resolved, which may represent the basis for future studies on the role of myocilin in glaucoma.

23 Review Too sweet: Problems of protein glycation in the eye. 2019

Bejarano, Eloy / Taylor, Allen. ·Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA, 02111, USA. Electronic address: eloy.bejarano@tufts.edu. · Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA, 02111, USA. Electronic address: allen.taylor@tufts.edu. ·Exp Eye Res · Pubmed #30145354.

ABSTRACT: Laboratory and epidemiological data indicate that high blood sugar levels and/or consuming high glycemia diets are linked to multiple age-related diseases, including age-related macular degeneration, cataract, Parkinson's disease, Alzheimer's disease, diabetic retinopathy, and, apparently glaucoma. High concentrations of blood sugar and perturbations of the systems that regulate blood sugar lead to the accumulation of advanced-glycation end products (AGEs). AGEs are toxic compounds that are formed from the combination of sugars and their metabolites with biomolecules in a non-enzymatic biochemical reaction called glycation. In vitro and in vivo data indicate that high sugar consumption is associated with accumulation of AGEs in a variety of human tissues. Hyperglycemia, along with an oxidative environment and limited cell proliferation in many ocular tissues, encourages formation and precludes dilution of AGEs and associated damage by cell division. These circumstances make many eye tissues vulnerable to glycation-derived damage. Here, we summarize research regarding glycation-induced ocular tissue dysfunction and its contribution to the onset and development of eye disorders. We also discuss how management of carbohydrate nutrition may provide a low-cost way to ameliorate the progression of AGEs-related diseases, including age related macular degeneration and some cataracts, as they do for cardiovascular disease and diabetes.

24 Review Pigment dispersion syndrome and pigmentary glaucoma: a review and update. 2019

Scuderi, Gianluca / Contestabile, Maria Teresa / Scuderi, Luca / Librando, Aloisa / Fenicia, Vito / Rahimi, Siavash. ·Ophthalmology Unit, St. Andrea Hospital, Faculty of Medicine and Psychology, NESMOS Department, University of Rome "Sapienza", Rome, Italy. · Ophthalmology Unit, Azienda Ospedaliera Universitaria Policlinico Umberto I, University of Rome "Sapienza", Viale del Policlinico 155, Rome, 00161, Italy. lucascuderi@hotmail.com. · Ophthalmology Unit, Azienda Ospedaliera Universitaria Policlinico Umberto I, University of Rome "Sapienza", Viale del Policlinico 155, Rome, 00161, Italy. · Pathology Centre-Histopathology, Queen Alexandra Hospital, School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK. ·Int Ophthalmol · Pubmed #29721842.

ABSTRACT: INTRODUCTION: Pigment dispersion syndrome (PDS) is a condition where anomalous iridozonular contact leads to pigment dispersion throughout the anterior segment and the released pigment is abnormally deposited on various ocular structures. CLINICAL PRESENTATION: The clinical presentation of PDS is defined by the presence of pigmented cells on the corneal endothelium, an increase of pigmentation of the trabecular meshwork, and mid-periphery transillumination defects of the iris. This syndrome, more common in myopes, is usually bilateral and can be associated with ocular hypertension or glaucoma. Secondary open-angle pigmentary glaucoma (PG) can develop due to reduction of the outflow of aqueous humour and consequent increase in intraocular pressure leading to glaucomatous optic neuropathy. Diagnosis of PG is commonly between 40 and 50 years of age, occurring more frequently in men. The advent of ultrasound biomicroscopy and anterior segment optical coherence tomography has contributed to enhancing our knowledge on the condition. Typical alterations of the anterior segment are the posterior insertion of the iris and iris concavity. Treatment of PG should be initiated early to hinder disease progression, glaucomatous damage, and vision loss. Management is based on medical therapy, laser iridotomy, selective laser trabeculoplasty, and filtration procedures. CONCLUSIONS: The differential diagnosis of PDS with other disorders can be challenging and awareness of the condition together with meticulous ophthalmologic examination allows early diagnosis followed by appropriate management strategies. The present review is a comprehensive report on the clinical characteristics, pathogenesis, current management, and status quo of PDS and PG.

25 Review The Rationale for Selective Laser Trabeculoplasty in Africa. 2018

Realini, Tony / Olawoye, Olusola / Kizor-Akaraiwe, Nkiru / Manji, Selina / Sit, Arthur. ·West Virginia University Eye Institute, Morgantown, WV. · Department of Ophthalmology, College of Medicine, University of Ibadan, Nigeria. · Enugu State University Teaching Hospital, Enugu, Nigeria. · Global Health Program, McMaster University, Hamilton, Ontario, Canada. · Mayo Clinic, Rochester, MN. ·Asia Pac J Ophthalmol (Phila) · Pubmed #30484574.

ABSTRACT: Glaucoma is the leading cause of irreversible blindness in Africa. The condition is treatable but not curable. There are numerous obstacles to glaucoma care in Africa, including availability, accessibility and affordability of treatments, as well as medication nonadherence among patients. Medical therapy is costly relative to the average income in Africa and it requires daily self-dosing by patients. Surgery is of limited availability in many regions in Africa, and a high proportion of patients refuse surgery because it is expensive. Selective laser trabeculoplasty (SLT) proves to be a favorable alternative to medical or surgical care, as it is highly effective and safe in people of African descent, more cost-effective than medical therapy, quick and easy to perform, and portable. The procedure also requires no postoperative care, thus obviates the issue of nonadherence. In uncontrolled studies, SLT has a high response rate and it lowers intraocular pressure by 30% to 40%, which exceeds the goal in international guidelines for initial therapies. The African Glaucoma Consortium (AGC), a member-driven stakeholder collective, has been formed in part to develop the infrastructure for continent-wide improvements in glaucoma care. It embraces SLT as a potential key tool in their development plans. The mission of AGC includes improving clinical care by educating existing and new health care professionals to expand the provider network, by conducting trials to identify optimal care strategies for glaucoma in Africa, and by facilitating the development of an integrated network of Centers of Excellence to bring SLT and other crucial glaucoma therapies to communities throughout Africa.

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